Citation: Cell Communication and Signaling 2017 15:20
Tumor Cell-Microenvironment Communication
From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases
Infections with the human pathogen Helicobacter pylori (H. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. Drastic changes in...
Citation: Cell Communication and Signaling 2017 15:15
The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation
Hypomethylating agents (HMAs) have been widely used over the last decade, approved for use in myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). The propos...
Citation: Cell Communication and Signaling 2017 15:13
Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?
Cancer represents heterogeneous and aberrantly proliferative manifestations composed of (epi)genetically and phenotypically distinct cells with a common clonal origin. Cancer stem cells (CSC) make up a rare su...
Citation: Cell Communication and Signaling 2017 15:12
Treatment of acute myeloid leukemia (AML), an aggressive and heterogeneous hematological malignancy, remains a challenge. Despite advances in our understanding of the complex genetics and biology of AML pathop...
Citation: Cell Communication and Signaling 2017 15:8
Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif. During development, th...
Citation: Cell Communication and Signaling 2017 15:7
Reactivation of dormant anti-tumor immunity – a clinical perspective of therapeutic immune checkpoint modulation
In favor of their outgrowth, cancer cells must resist immune surveillance and edit the immune response. Cancer immunoediting is characterized by fundamental changes in the cellular composition and the inflamma...
Citation: Cell Communication and Signaling 2017 15:5
The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoi...
Citation: Cell Communication and Signaling 2017 15:1