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Current Evidence and Future Directions in the Treatment of Colorectal Cancer

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  1. The objective of this study is to develop and validate a machine learning (ML) prediction model for the assessment of laparoscopic total mesorectal excision (LaTME) surgery difficulty, as well as to identify i...

    Authors: Xiangyong Li, Zeyang Zhou, Bing Zhu, Yong Wu and Chungen Xing
    Citation: World Journal of Surgical Oncology 2024 22:111
    Content type: Research Published on:

  2. Colorectal signet-ring cell carcinoma (SRCC) is a rare cancer with a bleak prognosis. The relationship between its clinicopathological features and survival remains incompletely elucidated. Tumor deposits (TD)...

    Authors: Fuchao Li, Lei Liu, Qingzhao Feng, Xiaohong Wang, Fang Liu, Li Yang, Lin Miao, Weiming Wang, Guozhong Ji and Chenggong Yu
    Citation: World Journal of Surgical Oncology 2024 22:107
    Content type: Research Published on:

  3. Temporary ileostomy (TI) has proven effective in reducing the severity of anastomotic leakage after rectal cancer surgery; however, some ileostomies fail to reverse over time, leading to conversion into a perm...

    Authors: Fan He, Chenglin Tang, Fuyu Yang, Defei Chen, Junjie Xiong, Yu Zou, Dongqin Zhao and Kun Qian
    Citation: World Journal of Surgical Oncology 2024 22:94
    Content type: Research Published on:

  4. Aimed to assess clinical effect of three-port inflatable robot-assisted thoracoscopic surgery in mediastinal tumor resection by comparing results of the robot group with the video group.

    Authors: Hao Peng, YuanPeng He, Siqi Sheng, Maierhaba Maitiyasen, Jingfeng Li, Yvxuan Liu, Jing Chen, Xinyu Hou, Haizhu Song and Jun Yi
    Citation: World Journal of Surgical Oncology 2024 22:83
    Content type: Research Published on:

  5. Locally advanced rectal cancer is typically treated using a combination of neoadjuvant chemoradiotherapy and total mesorectal resection. While achieving pathological complete response following neoadjuvant che...

    Authors: Jianguo Yang, Qican Deng, Yong Cheng, Zhongxue Fu and Xin Wu
    Citation: World Journal of Surgical Oncology 2024 22:31
    Content type: Research Published on:

  6. Certified cancer centers aim to ensure high-quality care by establishing structural and procedural standards according to evidence-based guidelines. Despite the high clinical and health policy relevance, evide...

    Authors: Veronika Bierbaum, Christoph Bobeth, Martin Roessler, Michael Gerken, Kees Kleihues-van Tol, Christoph Reissfelder, Alois Fürst, Christian Günster, Patrik Dröge, Thomas Ruhnke, Monika Klinkhammer-Schalke, Jochen Schmitt and Olaf Schoffer
    Citation: World Journal of Surgical Oncology 2024 22:11
    Content type: Research Published on:

  7. This study aimed to investigate the combined pathological risk factors (PRFs) to stratify low-risk (pT1-3N1) stage III colon cancer (CC), providing a basis for individualized treatment in the future.

    Authors: Zhen-Yu Xian, Yi-Wen Song, Zong-Jin Zhang, Ying-Guo Gan, Yong-Le Chen, Tuo Hu, Xiao-Feng Wen, Tai-Wei Mo and Xiao-Wen He
    Citation: World Journal of Surgical Oncology 2024 22:10
    Content type: Research Published on:

  8. The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery.

    Authors: Vladimír Procházka, Lukáš Lacina, Karel Smetana Jr, Martin Svoboda, Kateřina Skřivanová, Miroslava Beňovská, Jiří Jarkovský, Leoš Křen and Zdeněk Kala
    Citation: World Journal of Surgical Oncology 2023 21:384
    Content type: Research Published on:

  9. Prolonged postoperative ileus (PPOI) is a common complication after colorectal surgery that increases patient discomfort, hospital stay, and financial burden. However, predictive tools to assess the risk of PP...

    Authors: Fangliang Guo, Zhiwei Sun, Zongheng Wang, Jianfeng Gao, Jiahao Pan, Qianshi Zhang and Shuangyi Ren
    Citation: World Journal of Surgical Oncology 2023 21:380
    Content type: Research Published on:

  10. Systemic therapy is the standard treatment for unresectable colorectal cancer with liver metastasis (CRCLM). Transarterial chemoembolization with drug-eluting beads (DEB-TACE) is considered an effective treatm...

    Authors: Yen-Cheng Chen, Ching-Wen Huang, Ching-Chun Li, Tsung-Kun Chang, Wei-Chih Su, Po-Jung Chen, Yung-Sung Yeh, Yu-Tang Chang, Hsiang-Lin Tsai, Ming-Chen Paul Shih and Jaw-Yuan Wang
    Citation: World Journal of Surgical Oncology 2023 21:378
    Content type: Research Published on:

  11. The meta-analysis aimed to assess the clinical efficacy of chemotherapeutic triplet‐drug regimen combined with anti‐EGFR antibody in patients with initially unresectable metastatic colorectal cancer (mCRC). A ...

    Authors: Muyou Tian, Huifen Li, Wenjing Dong, Yuhong Li, Ting Jiang, Yanhua Lv, Jianxiong Zeng, Xiaomei Jiang, Zhaofeng Yin and Jianjun Xiao
    Citation: World Journal of Surgical Oncology 2023 21:355
    Content type: Research Published on:

  12. The purpose of this study was to investigate the use of thromboelastography (TEG) in patients with colorectal cancer and to examine whether the TEG parameters can be used as potential markers for disease scree...

    Authors: Zhang-Sheng Zhao, Yang-Cong Qi, Jing-Wei Wu, Li-Hui Qian, Bin Hu and You-Li Ma
    Citation: World Journal of Surgical Oncology 2023 21:354
    Content type: Research Published on:

  13. This study aimed to create a nomogram for predicting the recurrence of small bowel obstruction (SBO) after gastrectomy in patients with gastric cancer (GC) in order to provide better guidance for its diagnosis...

    Authors: Wenhao Yu, Qi Zhang, Muhammad Ali, Bangquan Chen, Yapeng Yang, Liuhua Wang, Qiannan Sun, Yong Wang and Daorong Wang
    Citation: World Journal of Surgical Oncology 2023 21:351
    Content type: Research Published on:

  14. Adding anti-epidermal growth factor receptor (anti-EGFR) target agents to conversion therapy may improve the resection rates and survival of patients with potentially resectable metastatic colorectal cancer (m...

    Authors: Yang Wang, Xiangyuan Li, Tongmin Huang, Dongying Wang, Yujing He, Mengfei Wei, Yujie Chen, Matao Zheng, Yetan Shi and Jianjian Zhang
    Citation: World Journal of Surgical Oncology 2023 21:340
    Content type: Research Published on:

  15. Obesity is a major global health problem and an important risk factor for colorectal cancer (CRC) is increased body weight. Obesity plays a role in the peritoneal dissemination of cancer; however, it is unclea...

    Authors: Vincent C. J. van de Vlasakker, Felice N. van Erning, Robin J. Lurvink, Ignace H. J. T. de Hingh and Simon W. Nienhuijs
    Citation: World Journal of Surgical Oncology 2023 21:328
    Content type: Research Published on:

  16. To investigate the relationship between dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) measurements and the potential composition of rectal carcinoma.

    Authors: Jie Yuan, Kun Liu, Yun Zhang, Yuchan Yang, Huihui Xu, Gang Han, Hua Lyu, Mengxiao Liu, Wenli Tan, Zhen Feng, Hangjun Gong and Songhua Zhan
    Citation: World Journal of Surgical Oncology 2023 21:306
    Content type: Research Published on:

  17. Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer is that a large part of the tumor volume is composed of a stroma with...

    Authors: Raquel Bodoque-Villar, David Padilla-Valverde, Lucía María González-López, José Ramón Muñoz-Rodríguez, Javier Arias-Pardilla, Clara Villar-Rodríguez, Francisco Javier Gómez-Romero, Gema Verdugo-Moreno, Francisco Javier Redondo-Calvo and Leticia Serrano-Oviedo
    Citation: World Journal of Surgical Oncology 2023 21:287
    Content type: Research Published on:

  18. The purpose of this study is to examine the impact of sequential transcatheter arterial chemoembolization (TACE) on the prognosis of patients with hepatocellular carcinoma (HCC) and microvascular invasion (MVI...

    Authors: Anwei Mo, Biquan Lin and Denglin Chen
    Citation: World Journal of Surgical Oncology 2023 21:277
    Content type: Review Published on:

  19. The optimal timing of surgery after neoadjuvant chemotherapy (NAC) in patients with synchronous colorectal cancer liver metastases (SLM) remains controversial. We plan to analyze whether the choice of differen...

    Authors: Yaoqun Wang, Ningyuan Wen, Xianze Xiong, Jiong Lu, Bei Li and Nansheng Cheng
    Citation: World Journal of Surgical Oncology 2023 21:276
    Content type: Research Published on:

  20. Colorectal cancer with a global incidence of 10% has multiple pathways implicated in its carcinogenesis. WNT signaling is the principal underlying pathway via APC gene, while defective mismatch repair genes an...

    Authors: Nisha Rateria, Ritu Ojha, Mridula Shukla and Manoj Pandey
    Citation: World Journal of Surgical Oncology 2023 21:275
    Content type: Case Report Published on:

  21. To report a rare gastroblastoma; discuss its clinical features, histopathological morphology, diagnosis, differential diagnosis, treatment, and prognosis; and so as to improve the understanding on this disease...

    Authors: Can Gong, Junyi Xu, Shuye Qiao, Xuemei Zhang and Min Yi
    Citation: World Journal of Surgical Oncology 2023 21:274
    Content type: Case Report Published on:

  22. Robotic colorectal surgery is becoming the preferred surgical approach for colorectal cancer (CRC). It offers several technical advantages over conventional laparoscopy that could improve patient outcomes. In ...

    Authors: Emile Farah, Andres A. Abreu, Benjamin Rail, Javier Salgado, Georgios Karagkounis, Herbert J. Zeh III and Patricio M. Polanco
    Citation: World Journal of Surgical Oncology 2023 21:272
    Content type: Research Published on:

  23. To explore relevant clinical factors of level IIB and contralateral level VI lymph node metastasis and evaluate the safety of low-collar extended incision (LCEI) for lymph node dissection in level II for papil...

    Authors: Yudong Ning, Yuebai Liu, Dingfen Zeng, Yuqiu Zhou, Linjie Ma, Shuang Dong, Jianfeng Sheng, Gaosong Wu, Wen Tian, Yongcong Cai and Chao Li
    Citation: World Journal of Surgical Oncology 2023 21:249
    Content type: Research Published on:

  24. The treatment strategy for locally advanced rectal cancer (LARC) has recently expanded from total mesorectal excision to additional neoadjuvant chemoradiotherapy (nCRT) and/or systemic chemotherapy (NAC). Data...

    Authors: Ryosuke Okamura, Yoshiro Itatani, Yusuke Fujita, Nobuaki Hoshino, Shintaro Okumura, Kazuhiro Nishiyama, Koya Hida and Kazutaka Obama
    Citation: World Journal of Surgical Oncology 2023 21:247
    Content type: Research Published on:

  25. The diagnostic criteria and effect of persistent descending mesocolon (PDM) on sigmoid and rectal cancers (SRCs) remain controversial. This study aims to clarify PDM patients' radiological features and short-t...

    Authors: Shiwen Mei, Mingguang Zhang, Feng Ye, Wenlong Qiu, Jichuan Quan, Meng Zhuang, Xishan Wang and Jianqiang Tang
    Citation: World Journal of Surgical Oncology 2023 21:199
    Content type: Research Published on:

  26. CEA and systemic inflammation were reported to correlate with proliferation, invasion, and metastasis of colorectal cancer. This study investigated the prognostic significance of the preoperative CEA and syste...

    Authors: Hao Cai, Yu Chen, Qiao Zhang, Yang Liu and HouJun Jia
    Citation: World Journal of Surgical Oncology 2023 21:178
    Content type: Research Published on:

  27. Colorectal cancer (CRC) is the second leading cause of cancer-related deaths globally. It is essential to identify new CRC-associated therapeutic targets and diagnostic biomarkers. Previous studies have demons...

    Authors: Ya’nan Zhen, Guodong Sun, Cunbao Chen, Jianqi Li, Ruixue Xiao and Zhongfa Xu
    Citation: World Journal of Surgical Oncology 2023 21:171
    Content type: Research Published on:

  28. Despite recent advances in therapy modalities of colorectal cancer (CRC), it is still the third cause of cancer-related deaths worldwide. Thus, the search for new target therapies became mandatory. DDR1 is a c...

    Authors: Marwa Mohammed Dawoud, Marwa Salah and Asmaa Shams El Dein Mohamed
    Citation: World Journal of Surgical Oncology 2023 21:168
    Content type: Research Published on:

  29. The tumor immune microenvironment plays a crucial role in the efficacy of various therapeutics. However, their correlation is not yet completely understood in Clear cell renal cell carcinoma (ccRCC). This stud...

    Authors: Yaling Pu, Danyang Cai, Lingling Jin, Fenfen Xu, Enru Ye, Lina Wu, Licai Mo, Suzhi Liu, Qunyi Guo and Gang Wu
    Citation: World Journal of Surgical Oncology 2023 21:156
    Content type: Research Published on:

  30. The role of adjuvant chemotherapy (AC) in stage III rectal cancer (RC) has been argued based on evidence from its use in colon cancer. Previous trials have analysed disease-free and overall survivals as endpoi...

    Authors: Kheng-Seong Ng, Charles Chan, Matthew John Francis Xavier Rickard, Anil Keshava, Peter Stewart and Pierre Henri Chapuis
    Citation: World Journal of Surgical Oncology 2023 21:152
    Content type: Research Published on:

  31. Total laparoscopic right hemicolectomy with complete mesocolic excision (CME), central vascular ligation (CVL), and D3 lymphadenectomy is still the most challenging colon procedures for gastrointestinal surgeo...

    Authors: Ngoc Hung Nguyen, Xuan Vinh Vu, Vu Quang Nguyen, The Hiep Nguyen, Huy Du Nguyen, Tuan Hiep Luong, Thanh Khiem Nguyen and Ham Hoi Nguyen
    Citation: World Journal of Surgical Oncology 2023 21:140
    Content type: Research Published on:

  32. In this retrospective study, we aimed to elucidate how the initial recurrence site influences the post-recurrence survival (PRS) after the curative resection of colorectal cancer.

    Authors: Hongjiang Pu, Yaxue Chen, Ruoxia Shen, Yin Zhang, Duan Yang, Lizhu Liu, Xingxiang Dong and Guangjun Yang
    Citation: World Journal of Surgical Oncology 2023 21:137
    Content type: Research Published on:

  33. The impact of preoperative anemia on a survival outcome and the importance of correcting preoperative anemia in patients with colorectal cancer (CRC) remain controversial. This study aimed to explore how preop...

    Authors: Yixu Deng, Meilin Weng and Jun zhang
    Citation: World Journal of Surgical Oncology 2023 21:122
    Content type: Research Published on:

  34. Anastomosis for gastrointestinal reconstruction has been contentious after low anterior resection of rectal cancer for the past 30 years. Despite the abundance of randomized controlled trials (RCTs) on colon J...

    Authors: Huabing Liu, Ming Xiong, Yu Zeng, Yabo Shi, Zhihui Pei and Chuanwen Liao
    Citation: World Journal of Surgical Oncology 2023 21:87
    Content type: Research Published on:

  35. D3 lymph node dissection with left colic artery (LCA) preservation in rectal cancer surgery seems to have little effect on reducing postoperative anastomotic leakage. So we first propose D3 lymph node dissecti...

    Authors: Xing Huang, Zhigang Xiao, Zhongcheng Huang and Dan Li
    Citation: World Journal of Surgical Oncology 2023 21:77
    Content type: Research Published on:

  37. Gastric cancer (GC) is one of the most common malignant tumors worldwide, and we hope to identify an economical but practical prognostic indicator. It has been reported that inflammatory indicators and tumor m...

    Authors: Liang Yu, Runben Jiang, Wanjing Chen, Yanwei Liu, Gui Wang, Xin Gong and Yong Wang
    Citation: World Journal of Surgical Oncology 2023 21:50
    Content type: Research Published on:

  38. To compare the prognostic value of tumor-infiltrating lymphocytes (TILs) and CD3 + cells and CD20 + cells between schistosomal colorectal cancer (SCRC) and non-schistosomal CRC (NSCRC).

    Authors: Weixia Wang, Yingyi Zhang, Jican Liu, Hongyan Jing, Kui Lu, Limei Wang, Ting Zhu, Yanchao Xu, Dacheng Bu, Meihong Cheng, Jing Liu, Weidong Shen, Junxia Yao and Sinian Huang
    Citation: World Journal of Surgical Oncology 2023 21:31
    Content type: Research Published on:

  39. In patients with colorectal cancer and clinically suspected para-aortic lymph node metastasis, the survival benefit of para-aortic lymphadenectomy is unknown. We conducted a meta-analysis and systematic review...

    Authors: Rong-Chang Wang, Jian-Qi Wang, Xiao-Yu Zhou, Chu-lin Zhong, Jin-Xu Chen and Jing-Song Chen
    Citation: World Journal of Surgical Oncology 2023 21:28
    Content type: Review Published on:

  40. Perianal Paget’s disease (PPD) is an intraepithelial invasion of the perianal skin and is frequently associated with underlying anorectal carcinoma. The relatively rare nature of this disease has made it diffi...

    Authors: Jun Imaizumi, Konosuke Moritani, Yasuyuki Takamizawa, Manabu Inoue, Shunsuke Tsukamoto and Yukihide Kanemitsu
    Citation: World Journal of Surgical Oncology 2023 21:17
    Content type: Research Published on:

  41. Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify thi...

    Authors: Zhizhan Ni, Yuepeng Cao, Liming Liu, Chenshen Huang, Huahao Xie, Jinzhe Zhou, Bujun Ge and Qi Huang
    Citation: World Journal of Surgical Oncology 2023 21:1
    Content type: Research Published on:

  42. Renal cell carcinoma (RCC) with haemangioblastoma-like characteristics is a type of RCC reported in recent years. RCC with (angio) leiomyomatous stroma (RCCLMS) was included as a provisional entity of the 2016...

    Authors: Jixia Kong, Juan Tao, Qimin Wang, Qingfu Zhang and Liying Yin
    Citation: World Journal of Surgical Oncology 2022 20:395
    Content type: Case Report Published on:

  43. Pulmonary sarcomatoid carcinoma (PSC) is a rare and unconventional non-small-cell lung cancer (NSCLC) that appears to be aggressive, with a poor prognosis and response to conventional treatment. Approximately ...

    Authors: Ying Wu, Zhecheng Yan, Juan Pan, Xiaona Chang, Bo Huang, Danju Luo, Rui Meng, Heshui Shi, Jun Fan and Xiu Nie
    Citation: World Journal of Surgical Oncology 2022 20:386
    Content type: Case Report Published on:

  44. Remnant gastric cancer (RGC) has been increasing for various reasons such as a longer life span, medical progress, and others. It generally has a poor prognosis, and its mechanism of occurrence is unknown. The...

    Authors: Yoshihiko Kakiuchi, Satoru Kikuchi, Shinji Kuroda, Shunsuke Kagawa and Toshiyoshi Fujiwara
    Citation: World Journal of Surgical Oncology 2022 20:374
    Content type: Research Published on:

  45. In rectal cancer (RC) surgery, the complexity of total mesorectal excision (TME) in laparoscopic sphincter-preserving surgery (lap-SPS) for RC near the anus has been a critical issue. Recently, technical assis...

    Authors: Satoru Kagami, Kimihiko Funahashi, Takamaru Koda, Toshimitsu Ushigome, Tomoaki Kaneko, Takayuki Suzuki, Yasuyuki Miura, Yasuo Nagashima, Kimihiko Yoshida and Akiharu Kurihara
    Citation: World Journal of Surgical Oncology 2022 20:363
    Content type: Research Published on:

  46. To report long-term oncological outcomes and organ preservation rate with a chemoradiotherapy-consolidation chemotherapy (CRT-CNCT) treatment for locally advanced rectal cancer (LARC).

    Authors: Oktar Asoglu, Alisina Bulut, Vusal Aliyev, Guglielmo Niccolò Piozzi, Koray Guven, Barıs Bakır and Suha Goksel
    Citation: World Journal of Surgical Oncology 2022 20:358
    Content type: Research Published on:

  47. Robotic surgery has been widely used in the radical treatment of colonic cancer. However, it is unclear what advantages the robotic approach offers over other approaches in left colectomy. This study aims to e...

    Authors: Zhixiang Huang, Taiyuan Li, Genghua Zhang, Zhen Zhou, Haoran Shi, Cheng Tang, Lingling Yang and Xiong Lei
    Citation: World Journal of Surgical Oncology 2022 20:345
    Content type: Research Published on:

  48. The aim of this study was to develop comprehensive and effective nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) rates in patients with colorectal mucinous adenocarcinoma (CRMA).

    Authors: Pengchao Wang, Qingyu Song, Ming Lu, Qingcheng Xia, Zijun Wang, Qinghong Zhao and Xiang Ma
    Citation: World Journal of Surgical Oncology 2022 20:330
    Content type: Research Published on:

  49. Preoperative absolute lymphocyte count (LC) and fibrinogen (FIB) are useful prognostic indicators in colorectal cancer (CRC). However, the prognostic value of the LC to FIB ratio (LFR) has never been addressed.

    Authors: Xiang Huang, Yu Huan, Long Liu, Qianwen Ye, Jian Guo and Bing Yan
    Citation: World Journal of Surgical Oncology 2022 20:309
    Content type: Research Published on:

  50. As transanal total mesorectal excision (taTME) is performed worldwide, the optimization of existing training and guidance programs to enhance new taTME learners’ competence in performing this procedure is warr...

    Authors: Fengming Xu, Yiqiao Zhang, Jiafu Yan, Bowen Xu, Guocong Wu, Zhengyang Yang, Liting Sun, Xiao Zhang, Hongwei Yao and Zhongtao Zhang
    Citation: World Journal of Surgical Oncology 2022 20:305
    Content type: Research Published on: