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Current Evidence and Future Directions in the Treatment of Colorectal Cancer

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  1. The meta-analysis aimed to assess the clinical efficacy of chemotherapeutic triplet‐drug regimen combined with anti‐EGFR antibody in patients with initially unresectable metastatic colorectal cancer (mCRC). A ...

    Authors: Muyou Tian, Huifen Li, Wenjing Dong, Yuhong Li, Ting Jiang, Yanhua Lv, Jianxiong Zeng, Xiaomei Jiang, Zhaofeng Yin and Jianjun Xiao
    Citation: World Journal of Surgical Oncology 2023 21:355
    Content type: Research Published on:

  2. The purpose of this study was to investigate the use of thromboelastography (TEG) in patients with colorectal cancer and to examine whether the TEG parameters can be used as potential markers for disease scree...

    Authors: Zhang-Sheng Zhao, Yang-Cong Qi, Jing-Wei Wu, Li-Hui Qian, Bin Hu and You-Li Ma
    Citation: World Journal of Surgical Oncology 2023 21:354
    Content type: Research Published on:

  3. This study aimed to create a nomogram for predicting the recurrence of small bowel obstruction (SBO) after gastrectomy in patients with gastric cancer (GC) in order to provide better guidance for its diagnosis...

    Authors: Wenhao Yu, Qi Zhang, Muhammad Ali, Bangquan Chen, Yapeng Yang, Liuhua Wang, Qiannan Sun, Yong Wang and Daorong Wang
    Citation: World Journal of Surgical Oncology 2023 21:351
    Content type: Research Published on:

  4. Adding anti-epidermal growth factor receptor (anti-EGFR) target agents to conversion therapy may improve the resection rates and survival of patients with potentially resectable metastatic colorectal cancer (m...

    Authors: Yang Wang, Xiangyuan Li, Tongmin Huang, Dongying Wang, Yujing He, Mengfei Wei, Yujie Chen, Matao Zheng, Yetan Shi and Jianjian Zhang
    Citation: World Journal of Surgical Oncology 2023 21:340
    Content type: Research Published on:

  5. Obesity is a major global health problem and an important risk factor for colorectal cancer (CRC) is increased body weight. Obesity plays a role in the peritoneal dissemination of cancer; however, it is unclea...

    Authors: Vincent C. J. van de Vlasakker, Felice N. van Erning, Robin J. Lurvink, Ignace H. J. T. de Hingh and Simon W. Nienhuijs
    Citation: World Journal of Surgical Oncology 2023 21:328
    Content type: Research Published on:

  6. To investigate the relationship between dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) measurements and the potential composition of rectal carcinoma.

    Authors: Jie Yuan, Kun Liu, Yun Zhang, Yuchan Yang, Huihui Xu, Gang Han, Hua Lyu, Mengxiao Liu, Wenli Tan, Zhen Feng, Hangjun Gong and Songhua Zhan
    Citation: World Journal of Surgical Oncology 2023 21:306
    Content type: Research Published on:

  7. Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer is that a large part of the tumor volume is composed of a stroma with...

    Authors: Raquel Bodoque-Villar, David Padilla-Valverde, Lucía María González-López, José Ramón Muñoz-Rodríguez, Javier Arias-Pardilla, Clara Villar-Rodríguez, Francisco Javier Gómez-Romero, Gema Verdugo-Moreno, Francisco Javier Redondo-Calvo and Leticia Serrano-Oviedo
    Citation: World Journal of Surgical Oncology 2023 21:287
    Content type: Research Published on:

  8. The purpose of this study is to examine the impact of sequential transcatheter arterial chemoembolization (TACE) on the prognosis of patients with hepatocellular carcinoma (HCC) and microvascular invasion (MVI...

    Authors: Anwei Mo, Biquan Lin and Denglin Chen
    Citation: World Journal of Surgical Oncology 2023 21:277
    Content type: Review Published on:

  9. The optimal timing of surgery after neoadjuvant chemotherapy (NAC) in patients with synchronous colorectal cancer liver metastases (SLM) remains controversial. We plan to analyze whether the choice of differen...

    Authors: Yaoqun Wang, Ningyuan Wen, Xianze Xiong, Jiong Lu, Bei Li and Nansheng Cheng
    Citation: World Journal of Surgical Oncology 2023 21:276
    Content type: Research Published on:

  10. Colorectal cancer with a global incidence of 10% has multiple pathways implicated in its carcinogenesis. WNT signaling is the principal underlying pathway via APC gene, while defective mismatch repair genes an...

    Authors: Nisha Rateria, Ritu Ojha, Mridula Shukla and Manoj Pandey
    Citation: World Journal of Surgical Oncology 2023 21:275
    Content type: Case Report Published on:

  11. To report a rare gastroblastoma; discuss its clinical features, histopathological morphology, diagnosis, differential diagnosis, treatment, and prognosis; and so as to improve the understanding on this disease...

    Authors: Can Gong, Junyi Xu, Shuye Qiao, Xuemei Zhang and Min Yi
    Citation: World Journal of Surgical Oncology 2023 21:274
    Content type: Case Report Published on:

  12. Robotic colorectal surgery is becoming the preferred surgical approach for colorectal cancer (CRC). It offers several technical advantages over conventional laparoscopy that could improve patient outcomes. In ...

    Authors: Emile Farah, Andres A. Abreu, Benjamin Rail, Javier Salgado, Georgios Karagkounis, Herbert J. Zeh III and Patricio M. Polanco
    Citation: World Journal of Surgical Oncology 2023 21:272
    Content type: Research Published on:

  13. To explore relevant clinical factors of level IIB and contralateral level VI lymph node metastasis and evaluate the safety of low-collar extended incision (LCEI) for lymph node dissection in level II for papil...

    Authors: Yudong Ning, Yuebai Liu, Dingfen Zeng, Yuqiu Zhou, Linjie Ma, Shuang Dong, Jianfeng Sheng, Gaosong Wu, Wen Tian, Yongcong Cai and Chao Li
    Citation: World Journal of Surgical Oncology 2023 21:249
    Content type: Research Published on:

  14. The treatment strategy for locally advanced rectal cancer (LARC) has recently expanded from total mesorectal excision to additional neoadjuvant chemoradiotherapy (nCRT) and/or systemic chemotherapy (NAC). Data...

    Authors: Ryosuke Okamura, Yoshiro Itatani, Yusuke Fujita, Nobuaki Hoshino, Shintaro Okumura, Kazuhiro Nishiyama, Koya Hida and Kazutaka Obama
    Citation: World Journal of Surgical Oncology 2023 21:247
    Content type: Research Published on:

  15. The diagnostic criteria and effect of persistent descending mesocolon (PDM) on sigmoid and rectal cancers (SRCs) remain controversial. This study aims to clarify PDM patients' radiological features and short-t...

    Authors: Shiwen Mei, Mingguang Zhang, Feng Ye, Wenlong Qiu, Jichuan Quan, Meng Zhuang, Xishan Wang and Jianqiang Tang
    Citation: World Journal of Surgical Oncology 2023 21:199
    Content type: Research Published on:

  16. CEA and systemic inflammation were reported to correlate with proliferation, invasion, and metastasis of colorectal cancer. This study investigated the prognostic significance of the preoperative CEA and syste...

    Authors: Hao Cai, Yu Chen, Qiao Zhang, Yang Liu and HouJun Jia
    Citation: World Journal of Surgical Oncology 2023 21:178
    Content type: Research Published on:

  17. Colorectal cancer (CRC) is the second leading cause of cancer-related deaths globally. It is essential to identify new CRC-associated therapeutic targets and diagnostic biomarkers. Previous studies have demons...

    Authors: Ya’nan Zhen, Guodong Sun, Cunbao Chen, Jianqi Li, Ruixue Xiao and Zhongfa Xu
    Citation: World Journal of Surgical Oncology 2023 21:171
    Content type: Research Published on:

  18. Despite recent advances in therapy modalities of colorectal cancer (CRC), it is still the third cause of cancer-related deaths worldwide. Thus, the search for new target therapies became mandatory. DDR1 is a c...

    Authors: Marwa Mohammed Dawoud, Marwa Salah and Asmaa Shams El Dein Mohamed
    Citation: World Journal of Surgical Oncology 2023 21:168
    Content type: Research Published on:

  19. The tumor immune microenvironment plays a crucial role in the efficacy of various therapeutics. However, their correlation is not yet completely understood in Clear cell renal cell carcinoma (ccRCC). This stud...

    Authors: Yaling Pu, Danyang Cai, Lingling Jin, Fenfen Xu, Enru Ye, Lina Wu, Licai Mo, Suzhi Liu, Qunyi Guo and Gang Wu
    Citation: World Journal of Surgical Oncology 2023 21:156
    Content type: Research Published on:

  20. The role of adjuvant chemotherapy (AC) in stage III rectal cancer (RC) has been argued based on evidence from its use in colon cancer. Previous trials have analysed disease-free and overall survivals as endpoi...

    Authors: Kheng-Seong Ng, Charles Chan, Matthew John Francis Xavier Rickard, Anil Keshava, Peter Stewart and Pierre Henri Chapuis
    Citation: World Journal of Surgical Oncology 2023 21:152
    Content type: Research Published on:

  21. Total laparoscopic right hemicolectomy with complete mesocolic excision (CME), central vascular ligation (CVL), and D3 lymphadenectomy is still the most challenging colon procedures for gastrointestinal surgeo...

    Authors: Ngoc Hung Nguyen, Xuan Vinh Vu, Vu Quang Nguyen, The Hiep Nguyen, Huy Du Nguyen, Tuan Hiep Luong, Thanh Khiem Nguyen and Ham Hoi Nguyen
    Citation: World Journal of Surgical Oncology 2023 21:140
    Content type: Research Published on:

  22. In this retrospective study, we aimed to elucidate how the initial recurrence site influences the post-recurrence survival (PRS) after the curative resection of colorectal cancer.

    Authors: Hongjiang Pu, Yaxue Chen, Ruoxia Shen, Yin Zhang, Duan Yang, Lizhu Liu, Xingxiang Dong and Guangjun Yang
    Citation: World Journal of Surgical Oncology 2023 21:137
    Content type: Research Published on:

  23. The impact of preoperative anemia on a survival outcome and the importance of correcting preoperative anemia in patients with colorectal cancer (CRC) remain controversial. This study aimed to explore how preop...

    Authors: Yixu Deng, Meilin Weng and Jun zhang
    Citation: World Journal of Surgical Oncology 2023 21:122
    Content type: Research Published on:

  24. Anastomosis for gastrointestinal reconstruction has been contentious after low anterior resection of rectal cancer for the past 30 years. Despite the abundance of randomized controlled trials (RCTs) on colon J...

    Authors: Huabing Liu, Ming Xiong, Yu Zeng, Yabo Shi, Zhihui Pei and Chuanwen Liao
    Citation: World Journal of Surgical Oncology 2023 21:87
    Content type: Research Published on:

  25. D3 lymph node dissection with left colic artery (LCA) preservation in rectal cancer surgery seems to have little effect on reducing postoperative anastomotic leakage. So we first propose D3 lymph node dissecti...

    Authors: Xing Huang, Zhigang Xiao, Zhongcheng Huang and Dan Li
    Citation: World Journal of Surgical Oncology 2023 21:77
    Content type: Research Published on:

  27. Gastric cancer (GC) is one of the most common malignant tumors worldwide, and we hope to identify an economical but practical prognostic indicator. It has been reported that inflammatory indicators and tumor m...

    Authors: Liang Yu, Runben Jiang, Wanjing Chen, Yanwei Liu, Gui Wang, Xin Gong and Yong Wang
    Citation: World Journal of Surgical Oncology 2023 21:50
    Content type: Research Published on:

  28. To compare the prognostic value of tumor-infiltrating lymphocytes (TILs) and CD3 + cells and CD20 + cells between schistosomal colorectal cancer (SCRC) and non-schistosomal CRC (NSCRC).

    Authors: Weixia Wang, Yingyi Zhang, Jican Liu, Hongyan Jing, Kui Lu, Limei Wang, Ting Zhu, Yanchao Xu, Dacheng Bu, Meihong Cheng, Jing Liu, Weidong Shen, Junxia Yao and Sinian Huang
    Citation: World Journal of Surgical Oncology 2023 21:31
    Content type: Research Published on:

  29. In patients with colorectal cancer and clinically suspected para-aortic lymph node metastasis, the survival benefit of para-aortic lymphadenectomy is unknown. We conducted a meta-analysis and systematic review...

    Authors: Rong-Chang Wang, Jian-Qi Wang, Xiao-Yu Zhou, Chu-lin Zhong, Jin-Xu Chen and Jing-Song Chen
    Citation: World Journal of Surgical Oncology 2023 21:28
    Content type: Review Published on:

  30. Perianal Paget’s disease (PPD) is an intraepithelial invasion of the perianal skin and is frequently associated with underlying anorectal carcinoma. The relatively rare nature of this disease has made it diffi...

    Authors: Jun Imaizumi, Konosuke Moritani, Yasuyuki Takamizawa, Manabu Inoue, Shunsuke Tsukamoto and Yukihide Kanemitsu
    Citation: World Journal of Surgical Oncology 2023 21:17
    Content type: Research Published on:

  31. Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify thi...

    Authors: Zhizhan Ni, Yuepeng Cao, Liming Liu, Chenshen Huang, Huahao Xie, Jinzhe Zhou, Bujun Ge and Qi Huang
    Citation: World Journal of Surgical Oncology 2023 21:1
    Content type: Research Published on:

  32. Renal cell carcinoma (RCC) with haemangioblastoma-like characteristics is a type of RCC reported in recent years. RCC with (angio) leiomyomatous stroma (RCCLMS) was included as a provisional entity of the 2016...

    Authors: Jixia Kong, Juan Tao, Qimin Wang, Qingfu Zhang and Liying Yin
    Citation: World Journal of Surgical Oncology 2022 20:395
    Content type: Case Report Published on:

  33. Pulmonary sarcomatoid carcinoma (PSC) is a rare and unconventional non-small-cell lung cancer (NSCLC) that appears to be aggressive, with a poor prognosis and response to conventional treatment. Approximately ...

    Authors: Ying Wu, Zhecheng Yan, Juan Pan, Xiaona Chang, Bo Huang, Danju Luo, Rui Meng, Heshui Shi, Jun Fan and Xiu Nie
    Citation: World Journal of Surgical Oncology 2022 20:386
    Content type: Case Report Published on:

  34. Remnant gastric cancer (RGC) has been increasing for various reasons such as a longer life span, medical progress, and others. It generally has a poor prognosis, and its mechanism of occurrence is unknown. The...

    Authors: Yoshihiko Kakiuchi, Satoru Kikuchi, Shinji Kuroda, Shunsuke Kagawa and Toshiyoshi Fujiwara
    Citation: World Journal of Surgical Oncology 2022 20:374
    Content type: Research Published on:

  35. In rectal cancer (RC) surgery, the complexity of total mesorectal excision (TME) in laparoscopic sphincter-preserving surgery (lap-SPS) for RC near the anus has been a critical issue. Recently, technical assis...

    Authors: Satoru Kagami, Kimihiko Funahashi, Takamaru Koda, Toshimitsu Ushigome, Tomoaki Kaneko, Takayuki Suzuki, Yasuyuki Miura, Yasuo Nagashima, Kimihiko Yoshida and Akiharu Kurihara
    Citation: World Journal of Surgical Oncology 2022 20:363
    Content type: Research Published on:

  36. To report long-term oncological outcomes and organ preservation rate with a chemoradiotherapy-consolidation chemotherapy (CRT-CNCT) treatment for locally advanced rectal cancer (LARC).

    Authors: Oktar Asoglu, Alisina Bulut, Vusal Aliyev, Guglielmo Niccolò Piozzi, Koray Guven, Barıs Bakır and Suha Goksel
    Citation: World Journal of Surgical Oncology 2022 20:358
    Content type: Research Published on:

  37. Robotic surgery has been widely used in the radical treatment of colonic cancer. However, it is unclear what advantages the robotic approach offers over other approaches in left colectomy. This study aims to e...

    Authors: Zhixiang Huang, Taiyuan Li, Genghua Zhang, Zhen Zhou, Haoran Shi, Cheng Tang, Lingling Yang and Xiong Lei
    Citation: World Journal of Surgical Oncology 2022 20:345
    Content type: Research Published on:

  38. The aim of this study was to develop comprehensive and effective nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) rates in patients with colorectal mucinous adenocarcinoma (CRMA).

    Authors: Pengchao Wang, Qingyu Song, Ming Lu, Qingcheng Xia, Zijun Wang, Qinghong Zhao and Xiang Ma
    Citation: World Journal of Surgical Oncology 2022 20:330
    Content type: Research Published on:

  39. Preoperative absolute lymphocyte count (LC) and fibrinogen (FIB) are useful prognostic indicators in colorectal cancer (CRC). However, the prognostic value of the LC to FIB ratio (LFR) has never been addressed.

    Authors: Xiang Huang, Yu Huan, Long Liu, Qianwen Ye, Jian Guo and Bing Yan
    Citation: World Journal of Surgical Oncology 2022 20:309
    Content type: Research Published on:

  40. As transanal total mesorectal excision (taTME) is performed worldwide, the optimization of existing training and guidance programs to enhance new taTME learners’ competence in performing this procedure is warr...

    Authors: Fengming Xu, Yiqiao Zhang, Jiafu Yan, Bowen Xu, Guocong Wu, Zhengyang Yang, Liting Sun, Xiao Zhang, Hongwei Yao and Zhongtao Zhang
    Citation: World Journal of Surgical Oncology 2022 20:305
    Content type: Research Published on:

  41. Upregulation of Stathmin 1 (STMN1), a cytoplasmic phosphoprotein that controls the dynamics of cellular microtubules, is linked to malignant behavior and poor prognosis in a range of malignancies. However, lit...

    Authors: En-di Zhang, Chenxuan Li, Yuan Fang, Na Li, Zhongyun Xiao, Chuhong Chen, Benkai Wei, Hangping Wang, Jincheng Xie, Yinglei Miao, Zhong Zeng and Hanfei Huang
    Citation: World Journal of Surgical Oncology 2022 20:301
    Content type: Research Published on:

  42. An investigation of the effects of different types of the inferior mesenteric artery (IMA) on laparoscopic left colic artery (LCA) radical resection of rectal cancer was conducted.

    Authors: Jinghao Chen, Meirong Wang, Yuhao Chen, Suying Chen, Jing Xiao, Xiaole Fan, Jushun Yang and Bosheng He
    Citation: World Journal of Surgical Oncology 2022 20:292
    Content type: Research Published on:

  43. Currently, high or low ligation of the inferior mesenteric artery (IMA) is a controversial issue in laparoscopic radical surgery for colorectal cancer. High or low ligation of the IMA has both advantages and d...

    Authors: Shun Zeng, Wenhao Wu, Xianbin Zhang, Tong Qiu and Peng Gong
    Citation: World Journal of Surgical Oncology 2022 20:290
    Content type: Review Published on:

  44. Venous thromboembolism (VTE) is a threat to the prognosis of tumor patients, especially for critically ill patients. No uniform standard model of VTE risk for critically ill patients with tumors was formatted ...

    Authors: Ruqi Mei, Guodong Wang, Renxiong Chen and Hongzhi Wang
    Citation: World Journal of Surgical Oncology 2022 20:245
    Content type: Research Published on:

  45. For sigmoid colon or rectal cancer, a definite consensus regarding the optimal level ligating the inferior mesenteric artery (IMA) has not been reached. We performed this study to determine whether the ligatio...

    Authors: Yawei Wang, Yan Wang, Liaonan Zou, Lingna Deng, Tianchong Wu, Linsen Liu, Jiling Jiang and Tailai An
    Citation: World Journal of Surgical Oncology 2022 20:274
    Content type: Research Published on:

  46. To investigate the effect and clinical significance of different thoracic surgical approaches for patients with stage IIB–IVA esophageal squamous cell carcinoma on the survival and prognosis of postoperative r...

    Authors: Mingcheng Gao, Yulin Zhu, Yan Gu, Zhan Shi, Jixiang Wu, Huiwen Chang and Jianxiang Song
    Citation: World Journal of Surgical Oncology 2022 20:271
    Content type: Research Published on:

  47. Few studies have evaluated the feasibility and safety of intracorporeal anastomosis (IA) for left hemicolectomy. Here, we aimed to investigate the potential advantages and disadvantages of laparoscopic left he...

    Authors: Li-Ming Wang, Bor-Kang Jong, Chun-Kai Liao, Ya-Ting Kou, Yih-Jong Chern, Yu-Jen Hsu, Pao-Shiu Hsieh, Wen-Sy Tsai and Jeng-Fu You
    Citation: World Journal of Surgical Oncology 2022 20:270
    Content type: Research Published on:

  48. Cutaneous melanoma (CM) is a skin cancer that is highly metastatic and aggressive, with a dismal prognosis. This is the first study to use inflammatory response-related genes to build a model and evaluate thei...

    Authors: Jiahua Xing, Yan Li, Youbai Chen and Yan Han
    Citation: World Journal of Surgical Oncology 2022 20:263
    Content type: Research Published on:

  49. To date, the optimal treatment for potentially resectable metastatic colorectal cancer (mCRC) patients has yet to be determined. Encouraging results have been reported in studies exploring the efficacy of trip...

    Authors: Qian Wu, Huan Wang, Suqin Zhang, Yifei Zeng, Wei Yang, Wenjun Pan, Guodai Hong and Wenbin Gao
    Citation: World Journal of Surgical Oncology 2022 20:258
    Content type: Research Published on:

  50. The morbidity and mortality of colorectal cancer (CRC) remain high, posing a serious threat to human life and health. The early diagnosis and prognostic evaluation of CRC are two major challenges in clinical p...

    Authors: Lin-Yao Cheng, Mao-sen Huang, Hua-Ge Zhong, Hai-Ming Ru, Si-Si Mo, Chun-Yin Wei, Zi-Jie Su, Xian-Wei Mo, Lin-Hai Yan and Wei-Zhong Tang
    Citation: World Journal of Surgical Oncology 2022 20:257
    Content type: Research Published on: