Traumatic Brain Injury – Acta Neuropathologica Communications

Guest Edited by: David G. Cook¹, Arman Fesharaki-Zadeh² & Marius Trésor Chiasseu^{2
1 University of Washington; 2 Yale School of Medicine}

Traumatic brain injury is extremely common, with estimates that more than 65 million individuals globally experience TBI inflicted from all causes each year. TBI is a highly significant cause of disability among all ages, nationalities, and demographic groups. Mild traumatic brain injury (mTBI) is the most common form, with estimates that more than 100 per 100,000 individuals worldwide require medical attention each year for mTBI.

Growing medical and research attention on mTBI is yielding new insights and a greater appreciation that mTBI, particularly repetitive mTBI, sets in motion often latent pathologic processes that can later emerge in association with a number of disorders that include Chronic Traumatic Encephalopathy (CTE), Alzheimer’s disease (AD), Parkinson’s disease like disorders, and other associated progressive neurodegenerative conditions.

This series highlights clinical, basic science, and translational studies that address current problems and knowledge gaps in mTBI, its links to chronic neurological, and psychiatric disorders including depression and posttraumatic stress disorder (PTSD). Topics well-aligned with this focus include, but are not limited to:

• Mechanistic and neuropathological studies of mTBI (eg. tau, phospho-TDP43, white matter injury)
• TBI biomarkers, including prospective biomarkers of chronic mTBI
• Neuroimaging biomarkers of mTBI
• Chronic neurocognitive and psychiatric sequelae of mTBI
• The links between TBI and other comorbidities