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Traumatic Brain Injury – Acta Neuropathologica Communications

Guest Edited by: David G. Cook1, Arman Fesharaki-Zadeh2 & Marius Trésor Chiasseu2
1 University of Washington; 2 Yale School of Medicine

Elder et al., 2013 © Elder et al., 2013

Traumatic brain injury is extremely common, with estimates that more than 65 million individuals globally experience TBI inflicted from all causes each year. TBI is a highly significant cause of disability among all ages, nationalities, and demographic groups. Mild traumatic brain injury (mTBI) is the most common form, with estimates that more than 100 per 100,000 individuals worldwide require medical attention each year for mTBI.

Growing medical and research attention on mTBI is yielding new insights and a greater appreciation that mTBI, particularly repetitive mTBI, sets in motion often latent pathologic processes that can later emerge in association with a number of disorders that include Chronic Traumatic Encephalopathy (CTE), Alzheimer’s disease (AD), Parkinson’s disease like disorders, and other associated progressive neurodegenerative conditions.

This series highlights clinical, basic science, and translational studies that address current problems and knowledge gaps in mTBI, its links to chronic neurological, and psychiatric disorders including depression and posttraumatic stress disorder (PTSD). Topics well-aligned with this focus include, but are not limited to:

  • Mechanistic and neuropathological studies of mTBI (eg. tau, phospho-TDP43, white matter injury)
  • TBI biomarkers, including prospective biomarkers of chronic mTBI
  • Neuroimaging biomarkers of mTBI
  • Chronic neurocognitive and psychiatric sequelae of mTBI
  • The links between TBI and other comorbidities
  1. In neurodegenerative diseases including Alzheimer’s, Parkinson’s and prion diseases, astrocytes acquire disease-associated reactive phenotypes. With growing appreciation of their role in chronic neurodegenerat...

    Authors: Natallia Makarava, Olga Mychko, Jennifer Chen-Yu Chang, Kara Molesworth and Ilia V. Baskakov
    Citation: Acta Neuropathologica Communications 2021 9:87
  2. Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies and 10–20% of the acquired forms. The latency between traumatic brain injury (TBI) and epilepsy onset in high-risk patients offers a therapeutic ...

    Authors: Rossella Di Sapia, Federico Moro, Marica Montanarella, Valentina Iori, Edoardo Micotti, Daniele Tolomeo, Kevin K. W. Wang, Annamaria Vezzani, Teresa Ravizza and Elisa R. Zanier
    Citation: Acta Neuropathologica Communications 2021 9:76
  3. Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmar...

    Authors: Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla and Zhen Zhao
    Citation: Acta Neuropathologica Communications 2021 9:74
  4. Traumatic brain injury (TBI) can result in progressive cognitive decline occurring for years after the initial insult, and for which there is currently no pharmacological treatment. An ongoing chronic inflamma...

    Authors: Khalil Mallah, Christine Couch, Mohammed Alshareef, Davis Borucki, Xiaofeng Yang, Ali Alawieh and Stephen Tomlinson
    Citation: Acta Neuropathologica Communications 2021 9:72
  5. Traumatic brain injury (TBI) is a major cause of long-term disability in young adults. An evidence-based treatment for TBI recovery, especially in the chronic phase, is not yet available. Using a severe TBI mo...

    Authors: Xuecheng Qiu, Suning Ping, Michele Kyle, Lawrence Chin and Li-Ru Zhao
    Citation: Acta Neuropathologica Communications 2021 9:63
  6. We have previously reported long-term changes in the brains of non-concussed varsity rugby players using magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and functional magnetic imaging (f...

    Authors: Xiaoyun Xu, Matthew Cowan, Flavio Beraldo, Amy Schranz, Patrick McCunn, Nicole Geremia, Zalman Brown, Maitray Patel, Karen L. Nygard, Reza Khazaee, Lihong Lu, Xingyu Liu, Michael J. Strong, Gregory A. Dekaban, Ravi Menon, Robert Bartha…
    Citation: Acta Neuropathologica Communications 2021 9:60
  7. Astrocytes with intracellular accumulations of misfolded phosphorylated tau protein have been observed in advanced-stage chronic traumatic encephalopathy (CTE) and in other neurodegenerative conditions. There ...

    Authors: Adam D. Bachstetter, Filip G. Garrett, Gregory A. Jicha and Peter T. Nelson
    Citation: Acta Neuropathologica Communications 2021 9:49
  8. The influence of the gut microbiota on traumatic brain injury (TBI) is presently unknown. This knowledge gap is of paramount clinical significance as TBI patients are highly susceptible to alterations in the g...

    Authors: Marta Celorrio, Miguel A. Abellanas, James Rhodes, Victoria Goodwin, Jennie Moritz, Sangeetha Vadivelu, Leran Wang, Rachel Rodgers, Sophia Xiao, Ilakkia Anabayan, Camryn Payne, Alexandra M. Perry, Megan T. Baldridge, Maria S. Aymerich, Ashley Steed and Stuart H. Friess
    Citation: Acta Neuropathologica Communications 2021 9:40
  9. Military veterans who experience blast-related traumatic brain injuries often suffer from chronic cognitive and neurobehavioral syndromes. Reports of abnormal tau processing following blast injury have raised ...

    Authors: Georgina Perez Garcia, Rita De Gasperi, Miguel A. Gama Sosa, Gissel M. Perez, Alena Otero-Pagan, Dylan Pryor, Rania Abutarboush, Usmah Kawoos, Patrick R. Hof, Dara L. Dickstein, David G. Cook, Sam Gandy, Stephen T. Ahlers and Gregory A. Elder
    Citation: Acta Neuropathologica Communications 2021 9:33
  10. Efforts to characterize the late effects of traumatic brain injury (TBI) have been in progress for some time. In recent years much of this activity has been directed towards reporting of chronic traumatic ence...

    Authors: Douglas H. Smith, Jean-Pierre Dollé, Kamar E. Ameen-Ali, Abigail Bretzin, Etty Cortes, John F. Crary, Kristen Dams-O’Connor, Ramon Diaz-Arrastia, Brian L. Edlow, Rebecca Folkerth, Lili-Naz Hazrati, Sidney R. Hinds, Diego Iacono, Victoria E. Johnson, C. Dirk Keene, Julia Kofler…
    Citation: Acta Neuropathologica Communications 2021 9:32
  11. Concussion or mild traumatic brain injury is the most common form of traumatic brain injury with potentially long-term consequences. Current objective diagnosis and treatment options are limited to clinical as...

    Authors: Xuan Vinh To and Fatima A. Nasrallah
    Citation: Acta Neuropathologica Communications 2021 9:2

    The Data Descriptor to this article has been published in Scientific Data 2021 8:207

  12. The lectin pathway (LP) of complement activation is believed to contribute to brain inflammation. The study aims to identify the key components of the LP contributing to TBI outcome as possible novel pharmacol...

    Authors: D. Mercurio, M. Oggioni, S. Fumagalli, N. J. Lynch, S. Roscher, D. Minuta, C. Perego, S. Ippati, R. Wallis, W. J. Schwaeble and M.-G. De Simoni
    Citation: Acta Neuropathologica Communications 2020 8:174
  13. Repeated exposure to mild TBI (mTBI) has been linked to an increased risk of Alzheimer’s disease (AD), chronic traumatic encephalopathy (CTE) and other neurodegenerative diseases. Some pathological features ty...

    Authors: Alexander Morin, Benoit Mouzon, Scott Ferguson, Daniel Paris, Mackenzie Browning, William Stewart, Mike Mullan and Fiona Crawford
    Citation: Acta Neuropathologica Communications 2020 8:166