Skip to main content

Towards Biomarkers of Human Immunosenescence

Topical Collection for Immunity & Ageing: Towards Biomarkers of Human Immunosenescense

Edited by:
Ruth R. Montgomery, PhD, Yale School of Medicine, United States of America
Alan Cohen, PhD, University of Sherbrooke, Canada

Towards Biomarker of Human Immunosenescence is a thematic series of the journal Immunity & Ageing. ‘Immunosenescence’ describes the multifactorial changes in the immune system with advanced age. To increase our understanding of the conditions of immune function in aging, the focus of this special issue is to document biomarkers of age-related immune conditions. We seek articles which highlight validated biomarkers or approaches to quantify immune aging, clarify heterogeneity among changes that accrue in aging, identify mechanisms underlying the altered state, or highlight where interventions may serve to improve health.  Articles may be commentaries or original research. Articles especially welcomed will address conceptual topics, detectable biomarkers, or clinical implications.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

Please find out more about our journal and its policies, here. Submission guidelines can be found here, and please submit to the series via our submission system (there will be a field for which you can indicate if you are submitting to this series).


  1. Global life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable marker of immune system aging is the presence of Aging-Related Immune Ce...

    Authors: Ahmed A. Y. Ragab, Margaret F. Doyle, Jiachen Chen, Yuan Fang, Kathryn L. Lunetta and Joanne M. Murabito
    Citation: Immunity & Ageing 2024 21:37
  2. Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is not only affect older people but can also occur in young individuals, ...

    Authors: Andrea Aprilia, Kusworini Handono, Hidayat Sujuti, Akhmad Sabarudin and Nuning Winaris
    Citation: Immunity & Ageing 2024 21:9
  3. TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands...

    Authors: Hyo-Jin Kim, Hyemin Kim, Jeong-Hyung Lee and Cheol Hwangbo
    Citation: Immunity & Ageing 2023 20:67
  4. Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to the growth of abnormal blood vessels into the macula, leading to the loss of central visi...

    Authors: Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen and Heping Xu
    Citation: Immunity & Ageing 2023 20:65
  5. Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers...

    Authors: Leire Iparraguirre, Ainhoa Alberro, Saioa GS Iñiguez, Maider Muñoz-Culla, Itziar Vergara, Ander Matheu and David Otaegui
    Citation: Immunity & Ageing 2023 20:33
  6. Immunosenescence is a complex process characterized by an age-related remodelling of immune system. The prominent effects of the immunosenescence process is the thymic involution and, consequently, the decreas...

    Authors: Ersilia Paparazzo, Silvana Geracitano, Vincenzo Lagani, Luigi Citrigno, Denise Bartolomeo, Mirella Aurora Aceto, Francesco Bruno, Raffaele Maletta, Giuseppe Passarino and Alberto Montesanto
    Citation: Immunity & Ageing 2023 20:16
  7. Immune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frailty is associated with impaired antibody and cellular mRNA vaccine responses.

    Authors: Charles T. Semelka, Michael E. DeWitt, Maria W. Blevins, Beth C. Holbrook, John W. Sanders and Martha A. Alexander-Miller
    Citation: Immunity & Ageing 2023 20:4
  8. CD8+ T cells play an important role in host defense against infections and malignancies as well as contribute to the development of inflammatory disorders. Alterations in the frequency of naïve and memory CD8+ T ...

    Authors: Min Sun Shin, Hong-Jai Park, Juan Young and Insoo Kang
    Citation: Immunity & Ageing 2022 19:66
  9. Aging and obesity are high risk factors for several conditions and diseases. They are both associated with systemic inflammation and they are both ameliorated by a healthy life style, suggesting that they may ...

    Authors: Daniela Frasca
    Citation: Immunity & Ageing 2022 19:48
  10. Biological aging represents a loss of integrity and functionality of physiological systems over time. While associated with an enhanced risk of adverse outcomes such as hospitalization, disability and death fo...

    Authors: Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney and George A. Kuchel
    Citation: Immunity & Ageing 2022 19:39
  11. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular...

    Authors: Md Mesbah Uddin, Ying Zhou, Alexander G. Bick, Bala Bharathi Burugula, Siddhartha Jaiswal, Pinkal Desai, Michael C. Honigberg, Shelly-Ann Love, Ana Barac, Kathleen M. Hayden, JoAnn E. Manson, Eric A. Whitsel, Charles Kooperberg, Pradeep Natarajan, Alexander P. Reiner and Jacob O. Kitzman
    Citation: Immunity & Ageing 2022 19:23