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Tau-based therapeutic strategies

Edited by Leonard Petrucelli.

This series of articles, published in Alzheimer's Research & Therapy, has not been sponsored. All articles have undergone the journal’s standard peer review process overseen by the Series Editor, with final decisions made by the Editors in Chief. The Series Editor and Editors in Chief declare no competing interests.

  1. Review

    Acetylation: a new key to unlock tau’s role in neurodegeneration

    The identification of tau protein as a major constituent of neurofibrillary tangles spurred considerable effort devoted to identifying and validating pathways through which therapeutics may alleviate tau burde...

    Casey Cook, Jeannette N Stankowski, Yari Carlomagno, Caroline Stetler and Leonard Petrucelli

    Alzheimer's Research & Therapy 2014 6:29

    Published on: 29 May 2014

  2. Review

    Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

    Microtubule-associated protein tau encoded by the MAPT gene binds to microtubules and is important for maintaining neuronal morphology and function. Alternative splicing of MAPT pre-mRNA generates six major tau i...

    Melissa E Murray, Naomi Kouri, Wen-Lang Lin, Clifford R Jack Jr, Dennis W Dickson and Prashanthi Vemuri

    Alzheimer's Research & Therapy 2014 6:1

    Published on: 2 January 2014

  3. Review

    Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

    Accumulation and aggregation of the microtubule-associated protein tau are a pathological hallmark of neurodegenerative disorders such as Alzheimer’s disease (AD). In AD, tau becomes abnormally phosphorylated ...

    Amy M Pooler, Manuela Polydoro, Susanne Wegmann, Samantha B Nicholls, Tara L Spires-Jones and Bradley T Hyman

    Alzheimer's Research & Therapy 2013 5:49

    Published on: 23 October 2013

  4. Review

    Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

    The Dominantly Inherited Alzheimer Network (DIAN) is an international registry of individuals at risk for developing autosomal dominant Alzheimer’s disease (AD). Its primary aims are to investigate the tempora...

    Krista L Moulder, B Joy Snider, Susan L Mills, Virginia D Buckles, Anna M Santacruz, Randall J Bateman and John C Morris

    Alzheimer's Research & Therapy 2013 5:48

    Published on: 17 October 2013