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Systems biotechnology and metabolic engineering

Edited by Prof Sang Yup Lee

Microbial Cell Factories invites submissions to this ongoing thematic series on the topic of Systems biotechnology and metabolic engineering. It is now time to exploit systems approaches to microbial biotechnology, starting with up-stream (strain, cell and organism development) by metabolic engineering, which will ultimately lead to successful biotechnology development when combined with systems engineering of mid- to down-stream processes. Please see here for further details, including how to submit your new work to the series.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

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  1. Content type: RESEARCH

    2-Keto-l-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation. In the second step, l-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicig...

    Authors: Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu and Yi-Xuan Zhang

    Citation: Microbial Cell Factories 2018 17:81

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  2. Content type: RESEARCH

    Thermostable lipases from microbial sources have been substantially overexpressed in E. coli, however, these enzymes are often produced with low-level enzymatic activity and mainly in the form of inclusion bodies...

    Authors: Weiqing Zhang, Jing Lu, Shuwen Zhang, Lu Liu, Xiaoyang Pang and Jiaping Lv

    Citation: Microbial Cell Factories 2018 17:50

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  3. Content type: RESEARCH

    Phenolic compounds generated in hydrolysis of lignocellulosic materials are major limiting factors for biological production of solvents by Clostridia, but it lacks the attention on the study of adaptation or res...

    Authors: Jun Liu, Qinlu Lin, Xueying Chai, Yunchuan Luo and Ting Guo

    Citation: Microbial Cell Factories 2018 17:35

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  4. Content type: Research

    Trichoderma reesei is one of the most important fungi utilized for cellulase production. However, its cellulase system has been proven to be present in suboptimal ratio for deconstruct...

    Authors: Yuanchao Qian, Lixia Zhong, Jia Gao, Ningning Sun, Yifan Wang, Guoyong Sun, Yinbo Qu and Yaohua Zhong

    Citation: Microbial Cell Factories 2017 16:207

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  5. Content type: Research

    Griseoviridin (GV) and viridogrisein (VG, also referred as etamycin), both biosynthesized by a distinct 105 kb biosynthetic gene cluster (BGC) in Streptomyces griseoviridis NRRL 2427, are a pair of synergistic st...

    Authors: Yunchang Xie, Junying Ma, Xiangjing Qin, Qinglian Li and Jianhua Ju

    Citation: Microbial Cell Factories 2017 16:177

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  6. Content type: Research

    5-Aminovaleric acid (5AVA) is an important five-carbon platform chemical that can be used for the synthesis of polymers and other chemicals of industrial interest. Enzymatic conversion of l-lysine to 5AVA has bee...

    Authors: Jae Ho Shin, Seok Hyun Park, Young Hoon Oh, Jae Woong Choi, Moon Hee Lee, Jae Sung Cho, Ki Jun Jeong, Jeong Chan Joo, James Yu, Si Jae Park and Sang Yup Lee

    Citation: Microbial Cell Factories 2016 15:174

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  7. Content type: Research

    Raspberry ketone is the primary aroma compound found in raspberries and naturally derived raspberry ketone is a valuable flavoring agent. The economic incentives for the production of raspberry ketone, combine...

    Authors: Danna Lee, Natoiya D. R. Lloyd, Isak S. Pretorius and Anthony R. Borneman

    Citation: Microbial Cell Factories 2016 15:49

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  8. Content type: Research

    With increasing concern about the environmental impact of a petroleum based economy, focus has shifted towards greener production strategies including metabolic engineering of microbes for the conversion of pl...

    Authors: Sarah Rodriguez, Charles M. Denby, T. Van Vu, Edward E. K. Baidoo, George Wang and Jay D. Keasling

    Citation: Microbial Cell Factories 2016 15:48

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  9. Content type: Research

    Nitrogen fixation has been established in protokaryotic model Escherichia coli by transferring a minimal nif gene cluster composed of 9 genes (nifB, nifH, nifD, nifK, nifE, nifN, nifX, hesA and nifV) from Paenib...

    Authors: Xin-Xin Li, Qi Liu, Xiao-Meng Liu, Hao-Wen Shi and San-Feng Chen

    Citation: Microbial Cell Factories 2016 15:43

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  10. Content type: Research

    Saccharomyces cerevisiae can be engineered to perform a multitude of different chemical reactions that are not programmed in its original genetic code. It has a large potential to func...

    Authors: Jan Dines Knudsen, Cecilia Hägglöf, Nora Weber and Magnus Carlquist

    Citation: Microbial Cell Factories 2016 15:37

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  11. Content type: Research

    (2S)-Pinocembrin is a chiral flavanone with versatile pharmacological and biological activities. Its health-promoting effects have spurred on research effects on the microbial production of (2S)-pinocembrin. Howe...

    Authors: Lei Guo, Xi Chen, Li-Na Li, Wei Tang, Yi-Ting Pan and Jian-Qiang Kong

    Citation: Microbial Cell Factories 2016 15:27

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  12. Content type: Research

    Imbalance in cofactors causing the accumulation of intermediates in biosynthesis pathways is a frequently occurring problem in metabolic engineering when optimizing a production pathway in a microorganism. In ...

    Authors: Veerle E. T. Maervoet, Sofie L. De Maeseneire, Fatma G. Avci, Joeri Beauprez, Wim K. Soetaert and Marjan De Mey

    Citation: Microbial Cell Factories 2016 15:23

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  13. Content type: Research

    An efficient microbial cell factory requires a microorganism that can utilize a broad range of substrates to economically produce value-added chemicals and fuels. The industrially important bacterium Corynebacter...

    Authors: Jungseok Lee, Jack N. Saddler, Youngsoon Um and Han Min Woo

    Citation: Microbial Cell Factories 2016 15:20

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  14. Content type: Research

    Plant parasitic nematodes are harmful to agricultural crops and plants, and may cause severe yield losses. Cinnamaldehyde, a volatile, yellow liquid commonly used as a flavoring or food additive, is increasing...

    Authors: Hyun Bae Bang, Yoon Hyeok Lee, Sun Chang Kim, Chang Keun Sung and Ki Jun Jeong

    Citation: Microbial Cell Factories 2016 15:16

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  15. Content type: Research

    Protoilludene is a valuable sesquiterpene and serves as a precursor for several medicinal compounds and antimicrobial chemicals. It can be synthesized by heterologous expression of protoilludene synthase in Esche...

    Authors: Liyang Yang, Chonglong Wang, Jia Zhou and Seon-Won Kim

    Citation: Microbial Cell Factories 2016 15:14

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  16. Content type: Research

    Designing optimal intracellular metabolism is essential for using microorganisms to produce useful compounds. Computerized calculations for flux balance analysis utilizing a genome-scale model have been perfor...

    Authors: Tomokazu Shirai, Takashi Osanai and Akihiko Kondo

    Citation: Microbial Cell Factories 2016 15:13

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  17. Content type: Research

    With the increasing global crude oil crisis and resulting environmental concerns, the production of biofuels from renewable resources has become increasingly important. One of the major challenges faced during...

    Authors: Furong Tan, Bo Wu, Lichun Dai, Han Qin, Zongxia Shui, Jingli Wang, Qili Zhu, Guoquan Hu and Mingxiong He

    Citation: Microbial Cell Factories 2016 15:4

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  18. Content type: Research

    Sustainable alternatives for the production of fuels and chemicals are needed to reduce our dependency on fossil resources and to avoid the negative impact of their excessive use on the global climate. Lignoce...

    Authors: Stefan Marcus Gaida, Andrea Liedtke, Andreas Heinz Wilhelm Jentges, Benedikt Engels and Stefan Jennewein

    Citation: Microbial Cell Factories 2016 15:6

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  19. Content type: Research

    Isepamicin is a weakly toxic but highly active aminoglycoside antibiotic derivative of gentamicin B. Gentamicin B is a naturally occurring minor component isolated from Micromonospora echinospora. 2ʹ-NH2-containi...

    Authors: Xianpu Ni, Zhenpeng Sun, Yawen Gu, Hao Cui and Huanzhang Xia

    Citation: Microbial Cell Factories 2016 15:1

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