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Systems Biology and Medicine

Edited by Stephan Feller and Fred Schaper

In systems biology and medicine a huge divide seems to exist at present between what ‘cloud castle architects’ anticipate and what their hard-working fellow experimental scientists can actually accomplish. The review articles in this collection published in Cell Communication and Signaling reflect on some of the current methodologies and results, providing a snapshot of selected aspects, with an emphasis on what can be done at present and what must still be accomplished to fulfill some of those very enthusiastic projections in the coming decade(s).

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

View all collections published in Cell Communication and Signaling

  1. Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use of rule-based representation ...

    Authors: Panuwat Trairatphisan, Andrzej Mizera, Jun Pang, Alexandru Adrian Tantar, Jochen Schneider and Thomas Sauter
    Citation: Cell Communication and Signaling 2013 11:46
  2. Apoptosis is a form of programmed cell death, which is fundamental to all multicellular organisms. Deregulation of apoptosis leads to a number of severe diseases including cancer. Apoptosis is initiated either...

    Authors: Kolja Schleich and Inna N Lavrik
    Citation: Cell Communication and Signaling 2013 11:44
  3. Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself i...

    Authors: Johannes Meiser, Daniel Weindl and Karsten Hiller
    Citation: Cell Communication and Signaling 2013 11:34
  4. Biological systems present multiple scales of complexity, ranging from molecules to entire populations. Light microscopy is one of the least invasive techniques used to access information from various biologic...

    Authors: Paul Paul Michel Aloyse Antony, Christophe Trefois, Aleksandar Stojanovic, Aidos Sagatovich Baumuratov and Karol Kozak
    Citation: Cell Communication and Signaling 2013 11:24