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Systems Medicine

Guest Editor: Dimiter Dimitrov MD, PhD

BMC Systems Biology invites you to submit to our new thematic series: Systems Medicine.

The thematic series on ‘Systems Medicine’ will review and feature applied translational research from biological mechanisms via the use of methods ranging from omics-based science, systems biology, bioinformatics and network theory to clinical practice, digital and mobile health. ​​

Futuristic tablet computerIn this respect, this thematic series on ‘Systems Medicine’ is closely related to personalized, stratified or precision medicine in that it is the approach that involves the tailoring of prevention, diagnosis and treatment, based on individual patient characteristics. 

The series will promote a set of translational practices intended to apply medical informatics tools – such as electronic decision support and patient-collected data – to improve patient care, usually with the secondary aim of making this data accessible for research and for the practical utilization of the patients. We will share a strong focus on the use of information (ICT) technologies and big data for the purposes of medical science or clinical care. Guest Editor Dimiter Dimitrov talks more about the ideas behind the series here.

We are seeking submissions of original research articles (including systematic reviews and meta-analyses), but also methodology, software and database articles. This collection in BMC Systems Biology will also include invited reviews.

We would welcome direct submission of any original research you would like to be considered. Please submit directly to BMC Systems Biology stating in your cover letter that you are targeting the 'Systems Medicine' collection. Alternatively you can email your pre-submission queries to

The deadline for submission of manuscripts is 15th June 2018

  1. Clinical integration of systems biology approaches is gaining in importance in the course of digital revolution in modern medicine. We present our results of the analysis of an extended mathematical model desc...

    Authors: Jan Christoph Banck and Dennis Görlich
    Citation: BMC Systems Biology 2019 13:18
  2. Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance...

    Authors: Frank Kramer, Steffen Just and Tanja Zeller
    Citation: BMC Systems Biology 2018 12:57
  3. Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the “o...

    Authors: James T. Yurkovich, Aarash Bordbar, Ólafur E. Sigurjónsson and Bernhard O. Palsson
    Citation: BMC Systems Biology 2018 12:31
  4. Osmanthus fragrans has been used as folk medicine for thousands of years. The extracts of Osmanthus fragrans flowers were reported to have various bioactivities including free radical ...

    Authors: Le Wang, Nana Tan, Jiayao Hu, Huan Wang, Dongzhu Duan, Lin Ma, Jian Xiao and Xiaoling Wang
    Citation: BMC Systems Biology 2017 11:144
  5. Systems healthcare is a holistic approach to health premised on systems biology and medicine. The approach integrates data from molecules, cells, organs, the individual, families, communities, and the natural ...

    Authors: Massimo S. Fiandaca, Mark Mapstone, Elenora Connors, Mireille Jacobson, Edwin S. Monuki, Shaista Malik, Fabio Macciardi and Howard J. Federoff
    Citation: BMC Systems Biology 2017 11:142
  6. The recent development of single-cell transcriptomics has enabled gene expression to be measured in individual cells instead of being population-averaged. Despite this considerable precision improvement, infer...

    Authors: Ulysse Herbach, Arnaud Bonnaffoux, Thibault Espinasse and Olivier Gandrillon
    Citation: BMC Systems Biology 2017 11:105
  7. One goal of personalized medicine is leveraging the emerging tools of data science to guide medical decision-making. Achieving this using disparate data sources is most daunting for polygenic traits. To this e...

    Authors: Cihan Oguz, Shurjo K. Sen, Adam R. Davis, Yi-Ping Fu, Christopher J. O’Donnell and Gary H. Gibbons
    Citation: BMC Systems Biology 2017 11:99
  8. Translating in vitro results to clinical tests is a major challenge in systems biology. Here we present a new Multi-Task learning framework which integrates thousands of cell line expression experiments to rec...

    Authors: Matthew Ruffalo, Petar Stojanov, Venkata Krishna Pillutla, Rohan Varma and Ziv Bar-Joseph
    Citation: BMC Systems Biology 2017 11:96