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Subject Cognitive Decline

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Target populations for early diagnosis, disease course prediction and interventions in Alzheimer’s disease are a major focus of current research. Subjective cognitive decline (SCD) has emerged as a pre-mild cognitive impairment (pre-MCI) at risk condition of dementia and cognitive decline. 

Initial studies provide evidence for an enrichment of AD pathology, particularly in memory clinic populations. Furthermore, there is evidence that biomarker evidence of AD pathology predict decline. The recent National Institute on Aging (NIA-AA) Alzheimer’s Association research criteria have linked SCD with the transitional stage 2 of AD, which reflect the initial pre-MCI symptomatic phase of the disease. 

Despite these highly promising first steps, SCD is still a new concept and numerous questions remain. The journal of Alzheimer’s disease and therapy address to emerging by topic by presenting a series of papers on SCD with new research of several of the leading groups in the field.

Guest Editors: José Luis Molinuevo, Frank Jessen &  Wiesje Van der Flier

This series will be publishing manuscripts throughout the year.

  1. Content type: Research

    Biomarkers such as cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) have predictive value for progression to dementia in patients with mild cognitive impairment (MCI). The pre-dementia stage take...

    Authors: Ingrid S. van Maurik, Rosalinde E. R. Slot, Sander C. J. Verfaillie, Marissa D. Zwan, Femke H. Bouwman, Niels D. Prins, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Mike P. Wattjes, Jose Luis Molinuevo, Lorena Rami, Steffen Wolfsgruber, Oliver Peters, Frank Jessen, Johannes Berkhof…

    Citation: Alzheimer's Research & Therapy 2019 11:33

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  2. Content type: Research

    Subjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer’s disease (AD) dementia and as a target population for future...

    Authors: Steffen Wolfsgruber, José Luis Molinuevo, Michael Wagner, Charlotte E. Teunissen, Lorena Rami, Nina Coll-Padrós, Femke H. Bouwman, Rosalinde E. R. Slot, Linda M. P. Wesselman, Oliver Peters, Katja Luther, Katharina Buerger, Josef Priller, Christoph Laske, Stefan Teipel, Annika Spottke…

    Citation: Alzheimer's Research & Therapy 2019 11:8

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  3. Content type: Research

    Subjective cognitive decline (SCD) consists of self-perceived decline in cognition over time. The occurrence of specific additional features in SCD (so-called SCDplus) confers a higher risk of future cognitive...

    Authors: Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Marc Suárez-Calvet, Carolina Minguillon, Raffaele Cacciaglia, Nina Gramunt, Carles Falcon, Juan Domingo Gispert and José Luis Molinuevo

    Citation: Alzheimer's Research & Therapy 2018 10:123

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