How cells respond to extracellular and intracellular stress is of central importance to cell communication and signaling. Toll-like receptors (TLRs), cGas-STING, and inflammasomes are among major pathways that allow cells to respond to a variety of cell stresses and challenges, but also permit a wide range of innate and adaptive responses to modify cellular, tissue, and organismal outcomes. It is now becoming appreciated that harnessing intrinsic stress and danger signals have potential therapeutic value. Likewise, insights into the structural and molecular biology of stress signaling pathway have led to the development of selective inhibitors with the potential to target axis pathways in a number of diseases. Our upcoming issue explores stress signaling pathways and their therapeutic applications, including the clinical potential in virology, vaccine development, and cancer immunotherapy.
Submissions to the series on the below topics are particularly welcome:
1) cGAS-STING pathway response towards microbial and host-derived DNAs;
2) Regulatory mechanisms of inflammasome activation (NLRPs, CARDs, AIM2, etc.) and TLR signaling;
3) Novel inflammasome ligands;
4) Targeting TLR pathways and;
5) Harnessing stress and immunogenic cell death pathways for therapeutic applications.
Guest Editor: Xiangya Ding, Nanjing Medical University
Submission Deadline: August 1, 2022