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Stem cell engineering and regenerative medicine

  1. A small scale stirred bioreactor was designed and the effect of different agitation rates (30, 60 and 100 rpm) was investigated on HepG2 cells cultured in alginate-chitosan (AC) core-shell microcapsule in term...

    Authors: Shahla Khodabakhshaghdam, Ali Baradar Khoshfetrat and Reza Rahbarghazi
    Citation: Journal of Biological Engineering 2021 15:14
    Content type: Research Published on:

  3. Traffic accidents, falls, and many other events may cause traumatic spinal cord injuries (SCIs), resulting in nerve cells and extracellular matrix loss in the spinal cord, along with blood loss, inflammation, ...

    Authors: Ziyuan Yu, Hongru Li, Peng Xia, Weijian Kong, Yuxin Chang, Chuan Fu, Kai Wang, Xiaoyu Yang and Zhiping Qi
    Citation: Journal of Biological Engineering 2020 14:22
    Content type: Review Published on:

  4. The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and f...

    Authors: Hongru Li, Su Pan, Peng Xia, Yuxin Chang, Chuan Fu, Weijian Kong, Ziyuan Yu, Kai Wang, Xiaoyu Yang and Zhiping Qi
    Citation: Journal of Biological Engineering 2020 14:14
    Content type: Review Published on:

  5. Liver metabolites are used to diagnose disease and examine drugs in clinical pharmacokinetics. Therefore, development of an in vitro assay system that reproduces liver metabolite recovery would provide importa...

    Authors: Astia Rizki-Safitri, Marie Shinohara, Minoru Tanaka and Yasuyuki Sakai
    Citation: Journal of Biological Engineering 2020 14:11
    Content type: Research Published on:

  6. Tissue engineering, as an interdisciplinary approach, is seeking to create tissues with optimal performance for clinical applications. Various factors, including cells, biomaterials, cell or tissue culture con...

    Authors: Azizeh Rahmani Del Bakhshayesh, Nahideh Asadi, Alireza Alihemmati, Hamid Tayefi Nasrabadi, Azadeh Montaseri, Soodabeh Davaran, Sepideh Saghati, Abolfazl Akbarzadeh and Ali Abedelahi
    Citation: Journal of Biological Engineering 2019 13:85
    Content type: Review Published on:

  7. Equine mesenchymal stromal cells (MSCs) are increasingly investigated for their clinical therapeutic utility. Such cell-based treatments can require cell numbers in the millions or billions, with conventional ...

    Authors: Erin L. Roberts, Tiffany Dang, Sarah I. M. Lepage, Amir Hamed Alizadeh, Tylor Walsh, Thomas G. Koch and Michael S. Kallos
    Citation: Journal of Biological Engineering 2019 13:25
    Content type: Research Published on:

  8. The repair or replacement of damaged skins is still an important, challenging public health problem. Immune acceptance and long-term survival of skin grafts represent the major problem to overcome in grafting ...

    Authors: Saurabh Dixit, Dieudonné R. Baganizi, Rajnish Sahu, Ejowke Dosunmu, Atul Chaudhari, Komal Vig, Shreekumar R. Pillai, Shree R. Singh and Vida A. Dennis
    Citation: Journal of Biological Engineering 2017 11:49
    Content type: Review Published on:

  9. The blood-brain barrier (BBB) is the interface between the vasculature and the brain, regulating molecular and cellular transport into the brain. Endothelial cells (ECs) that form the capillary walls constitut...

    Authors: John J. Jamieson, Peter C. Searson and Sharon Gerecht
    Citation: Journal of Biological Engineering 2017 11:37
    Content type: Review Published on:

  11. Liver disease contributes significantly to global disease burden and is associated with rising incidence and escalating costs. It is likely that innovative approaches, arising from the emerging field of liver ...

    Authors: Ogechi Ogoke, Janet Oluwole and Natesh Parashurama
    Citation: Journal of Biological Engineering 2017 11:46
    Content type: Review Published on:

  12. The accumulated evidence points to the microenvironment as the primary mediator of cellular fate determination. Comprised of parenchymal cells, stromal cells, structural extracellular matrix proteins, and sign...

    Authors: Patrick C. Sachs, Peter A. Mollica and Robert D. Bruno
    Citation: Journal of Biological Engineering 2017 11:34
    Content type: Review Published on:

  13. Human induced pluripotent stem cells (hiPSCs) can form any tissue found in the body, making them attractive for regenerative medicine applications. Seeding hiPSC aggregates into biomaterial scaffolds can contr...

    Authors: Meghan E. Hall, Nima Khadem Mohtaram, Stephanie M. Willerth and Roderick Edwards
    Citation: Journal of Biological Engineering 2017 11:38
    Content type: Research Published on:

  14. With additive manufacturing (AM) individual and biocompatible implants can be generated by using suitable materials. The aim of this study was to investigate the biological effects of polylactic acid (PLA) man...

    Authors: Matthias C. Wurm, Tobias Möst, Bastian Bergauer, Dominik Rietzel, Friedrich Wilhelm Neukam, Sandra C. Cifuentes and Cornelius von Wilmowsky
    Citation: Journal of Biological Engineering 2017 11:29
    Content type: Research Published on:

  15. Recent advances in the expansion and directed pancreatogenic differentiation of human pluripotent stem cells (hPSCs) have intensified efforts to generate functional pancreatic islet cells, especially insulin-s...

    Authors: Elena F. Jacobson and Emmanuel S. Tzanakakis
    Citation: Journal of Biological Engineering 2017 11:21
    Content type: Review Published on: