Pluripotent Stem Cells: Research Review
About the Collection
This unique multi-journal collection includes research and perspectives on the topic of pluripotent stem cells. Ranging from journals focusing on cell death, epigenetics, stem cell therapy and cell signaling, this interdisciplinary collection features articles new and old which reflect the recent trends in this field of research. Articles featured in this collection were curated by Editors from the following journals: Cell Death Discovery, Cell Communication and Signaling, Clinical Epigenetics, Genome Biology, Genome Medicine, and Stem Cell Research and Therapy.
Mapping human pluripotent stem cell differentiation pathways using high throughput single-cell RNA-sequencing
Human pluripotent stem cells (hPSCs) provide powerful models for studying cellular differentiations and unlimited sources of cells for regenerative medicine. However, a comprehensive single-cell level differen...
Xiaoping Han, Haide Chen, Daosheng Huang, Huidong Chen, Lijiang Fei, Chen Cheng, He Huang, Guo-Cheng Yuan and Guoji Guo
Genome Biology 2018 19:47
Published on: 5 April 2018
Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells
Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive ...
Ruhang Tang, Liufang Jing, Vincent P. Willard, Chia-lung Wu, Farshid Guilak, Jun Chen and Lori A. Setton
Highly efficient and expedited hepatic differentiation from human pluripotent stem cells by pure small-molecule cocktails
The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes. Although previous efforts have succeeded in generating hepatocytes from human pluripotent ...
Cong Du, Yuan Feng, Dongbo Qiu, Yan Xu, Mao Pang, Nan Cai, Andy Peng Xiang and Qi Zhang
Stem Cell Research & Therapy 2018 9:58
Published on: 9 March 2018
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Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells
Human induced pluripotent stem cells (iPSCs) are a valuable tool for studying the cardiac developmental process in vitro, and cardiomyocytes derived from iPSCs are a putative cell source for personalized medic...
Ashfaqul Hoque, Priyadharshini Sivakumaran, Simon T. Bond, Naomi X. Y. Ling, Anne M. Kong, John W. Scott, Nadeeka Bandara, Damián Hernández, Guei-Sheung Liu, Raymond C. B. Wong, Michael T. Ryan, Derek J. Hausenloy, Bruce E. Kemp, Jonathan S. Oakhill, Brian G. Drew, Alice Pébay…
One-step genetic correction of hemoglobin E/beta-thalassemia patient-derived iPSCs by the CRISPR/Cas9 system
Thalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy. The definitive cure for thalassemia is allogeneic hematopoieti...
Methichit Wattanapanitch, Nattaya Damkham, Ponthip Potirat, Kongtana Trakarnsanga, Montira Janan, Yaowalak U-pratya, Pakpoom Kheolamai, Nuttha Klincumhom and Surapol Issaragrisil
Stem Cell Research & Therapy 2018 9:46
Published on: 26 February 2018
Preserving self-renewal of porcine pluripotent stem cells in serum-free 3i culture condition and independent of LIF and b-FGF cytokines
Derivation of bona fide porcine pluripotent stem cells is still a critical issue because porcine embryonic stem cells (ESCs) are not available yet, and most of the culture conditions to maintain porcine induce...
Yangyang Ma, Tong Yu, Yuanxing Cai and Huayan Wang
Modeling cancer using patient-derived induced pluripotent stem cells to understand development of childhood malignancies
In vitro modeling of complex diseases is now a possibility with the use of patient-derived induced pluripotent stem (iPS) cells. Their stem cell properties, including self-renewal and their potential to virtua...
Ana Marin Navarro, Evelyn Susanto, Anna Falk and Margareta Wilhelm
DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling
Genetic predisposition and epigenetic alterations are both considered to contribute to sporadic neurodegenerative diseases (NDDs) such as Parkinson’s disease (PD). Since cell reprogramming and the generation o...
Laura de Boni, Gilles Gasparoni, Carolin Haubenreich, Sascha Tierling, Ina Schmitt, Michael Peitz, Philipp Koch, Jörn Walter, Ullrich Wüllner and Oliver Brüstle
Clinical Epigenetics 2018 10:13
Published on: 29 January 2018
SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells
Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential fo...
Özgen Deniz, Lorenzo de la Rica, Kevin C. L. Cheng, Dominik Spensberger and Miguel R. Branco
Genome Biology 2018 19:6
Published on: 19 January 2018
Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells
Germline chromothripsis causes complex genomic rearrangements that are likely to affect multiple genes and their regulatory contexts. The contribution of individual rearrangements and affected genes to the phe...
Sjors Middelkamp, Sebastiaan van Heesch, A. Koen Braat, Joep de Ligt, Maarten van Iterson, Marieke Simonis, Markus J. van Roosmalen, Martijn J. E. Kelder, Evelien Kruisselbrink, Ron Hochstenbach, Nienke E. Verbeek, Elly F. Ippel, Youri Adolfs, R. Jeroen Pasterkamp, Wigard P. Kloosterman, Ewart W. Kuijk…
Genome Medicine 2017 9:9
Published on: 26 January 2017
The quest for an effective and safe personalized cell therapy using epigenetic tools
In the presence of different environmental cues that are able to trigger specific responses, a given genotype has the ability to originate a variety of different phenotypes. This property is defined as plastic...
T. A. L. Brevini, G. Pennarossa, E. F. M. Manzoni, C. E. Gandolfi, A. Zenobi and F. Gandolfi
Clinical Epigenetics 2016 8:119
Published on: 16 November 2016
Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome
Common genetic variation and rare mutations in genes encoding calcium channel subunits have pleiotropic effects on risk for multiple neuropsychiatric disorders, including autism spectrum disorder (ASD) and sch...
Yuan Tian, Irina Voineagu, Sergiu P Paşca, Hyejung Won, Vijayendran Chandran, Steve Horvath, Ricardo E Dolmetsch and Daniel H Geschwind
Genome Medicine 2014 6:75
Published on: 10 October 2014
Recent development and biomedical applications of probabilistic Boolean networks
Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use of rule-based representation ...
Panuwat Trairatphisan, Andrzej Mizera, Jun Pang, Alexandru Adrian Tantar, Jochen Schneider and Thomas Sauter
Cell Communication and Signaling 2013 11:46
Published on: 1 July 2013
Complexity of dopamine metabolism
Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself i...
Johannes Meiser, Daniel Weindl and Karsten Hiller
Cell Communication and Signaling 2013 11:34
Published on: 17 May 2013
Cancer stem cells in solid tumors: elusive or illusive?
During the past years in vivo transplantation experiments and in vitro colony-forming assays indicated that tumors arise only from rare cells. These cells were shown to bear self-renewal capacities and the abilit...
Yvonne Welte, James Adjaye, Hans R Lehrach and Christian RA Regenbrecht
Cell Communication and Signaling 2010 8:6
Published on: 11 May 2010