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Stem cell therapy of COVID-19 and other respiratory diseases

Guest edited by Hong-Long James Ji (University of Texas Health Science Center at Tyler), Michael A. Matthay (University of California, San Francisco) and Yuanlin Song (Fudan University)

A thematic series in Stem Cell Research & Therapy

respiratory diseases © Sergey Nivens /

Pulmonary diseases are the leading cause of death globally. Chronic obstructive pulmonary disease (COPD) alone is the top third-ranked killer, followed by lower respiratory infections. COVID-19 pandemic and other critically respiratory infections claim millions of lives annually. Most respiratory diseases, including COPD, lung cancer, idiopathic pulmonary fibrosis, asthma, and acute respiratory distress syndrome (ARDS), are refractory illnesses. Stem cell therapy holds the most promising to regenerate functional “new” lungs. Very recently, considerable progress has been reported in the physiology, pathology, and biology of respiratory stem cells. These preclinical studies applied single-cell analyses, multi-omics, decellularized lungs, 3D printing, 3D organoids, machine learning algorithms, and organ-on-a-chip methodologies. Registered clinical trials are growing rapidly for studying the feasibility, safety, and benefits of stem cells and their extracellular vesicles for COVID-19 and other respiratory diseases.

This thematic series aims to focus on the mechanisms or outcomes of adult stem cell therapies in preclinical models and clinical trials to treat respiratory diseases for a safe and effective outcome. 

  1. The COVID-19 pandemic, caused by the rapid global spread of the novel coronavirus (SARS-CoV-2), has caused healthcare systems to collapse and led to hundreds of thousands of deaths. The clinical spectrum of CO...

    Authors: Kátia Nunes da Silva, André Luiz Nunes Gobatto, Zaquer Suzana Munhoz Costa-Ferro, Bruno Raphael Ribeiro Cavalcante, Alex Cleber Improta Caria, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Fernanda de Macêdo Lima, Miquéias Lopes-Pacheco, Patricia Rieken Macêdo Rocco and Bruno Solano de Freitas Souza

    Citation: Stem Cell Research & Therapy 2021 12:425

    Content type: Review

    Published on:

  2. Mesenchymal stem cells (MSCs) have received particular attention because of their ability to modulate the immune system and inhibit inflammation caused by cytokine storms due to SARS-CoV-2. New alternative the...

    Authors: Mahshid Saleh, Amir Abbas Vaezi, Rasoul Aliannejad, Amir Ali Sohrabpour, Seyedeh Zahra Fotook Kiaei, Mahdi Shadnoush, Vahid Siavashi, Leila Aghaghazvini, Batoul Khoundabi, Shahriyar Abdoli, Bahram Chahardouli, Iman Seyhoun, Neda Alijani and Javad Verdi

    Citation: Stem Cell Research & Therapy 2021 12:410

    Content type: Research

    Published on: