Skip to main content

Sphingomyelin: Key Roles in Health and Disease

New Content ItemSphingomyelin Involvement in Cancer and Parasites Immune Evasion

Edited by Rashika El Ridi and Junfei Jin

Lipids in Health and Disease invites you to contribute a manuscript to our new thematic series, “Sphingomyelin: Key Roles in Health and Disease”.

Sphingolipids were named after the mythological sphinx because of their enigmatic nature.  Sphingolipids, like the sphinx, are composed of diverse subunits: an amino diol, sphingosine, bound to a fatty acid by an amide linkage, and a polar head group.  Perhaps the best known sphinx is the Great Sphinx of Giza. Similarly famous and enigmatic is sphingomyelin (SM), which contains predominantly a phosphocholine as head group. Sphingomyelin is abundant in the outer leaflet of cell plasma membranes where it with cholesterol forms lipid rafts, which serve as platforms for proteins and protein assemblies involved in signal transduction.  Additionally, SM is the most abundant sphingolipid in plasma lipoproteins.  Removal of the head group phosphocholine by sphingomyelinases generates a product with hydrogen as head group, ceramide, an apoptosis-inducing, and messenger death molecule.

Accumulation of SM and decrease in ceramide levels are implicated in tumor initiation, immune evasion, growth, and metastasis.  Additionally, reports document SM roles in atherosclerosis, Alzheimer, and diseases mediated by human immunodeficiency virus and prion invasion. Interactions of sphingolipid metabolism of numerous parasites, such as Plamodium, Trypanosoma, Toxoplasma, Schistosoma with that of the host contribute to parasite survival and/or host defense. 

We wish to welcome articles, including original research, narrative reviews, systematic reviews and meta-analysis, and mini-reviews which establish the relation between SM metabolism and cancer immune evasion, thus allowing the discovery of unprecedented approaches and new molecules for cancer prevention and therapy.  Of great interest would be articles clarifying the intricacies of SM involvement in atherosclerosis, diabetes, Alzheimer, and diseases caused by viruses and prion.  Such articles are expected to open avenues for prevention and therapy of these severe afflictions. The topics that will be particularly welcomed for submission in the issue are those addressing the identification and characterization of SM-related virulence factors and pathways of human parasites, and aiming towards development of novel therapeutic options and molecules.

All submissions should be made by June 30th, 2022.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

Please find out more about our journal and its policies, here. Submission guidelines can be found here, and please submit to the series via our submission system (there will be a field for which you can indicate if you are submitting to this series).

  1. Stroke is the leading cause of death in humans worldwide, and its incidence increases every year. It is well documented that lipids are closely related to stroke. Analyzing the changes in lipid content in the ...

    Authors: Keqi Zeng, Xin Zhou, Wanyi Liu, Cong Nie and Yingfeng Zhang
    Citation: Lipids in Health and Disease 2023 22:13
  2. Retinol-binding protein 4 (RBP4) has been considered to be related to metabolic related diseases, such as hyperuricemia, obesity, and diabetes mellitus. However, whether nonalcoholic fatty liver disease (NAFLD...

    Authors: Rui Hu, Xiaoyue Yang, Xiaoyu He and Guangyao Song
    Citation: Lipids in Health and Disease 2023 22:8
  3. The triglyceride–glucose index (TyG index), an alternative indicator of peripheral insulin resistance (IR), is associated with cardiovascular disease (CVD) in the general population. The aim of this research w...

    Authors: Wenqi Xu, Haiyan Zhao, Xu Han, Jianrong Liu, Haixia Li, Junyan Sun, Aijun Xing, Shuohua Chen, Shouling Wu and Yuntao Wu
    Citation: Lipids in Health and Disease 2023 22:3
  4. This systematic review and dose–response meta-analysis of published randomized controlled trials (RCTs) was conducted to determine the effectiveness of camelina oil supplementation (COS) on lipid profiles and ...

    Authors: Cyrus Jalili, Sepide Talebi, Sanaz Mehrabani, Reza Bagheri, Alexei Wong, Parsa Amirian, Mahsa Zarpoosh, Seyed Mojtaba Ghoreishy, Mohammad Ali Hojjati Kermani and Sajjad Moradi
    Citation: Lipids in Health and Disease 2022 21:132
  5. Non-alcoholic fatty liver (NAFLD) is a complex metabolic disease characterized by fatty degeneration of hepatocytes. Circular RNAs (circRNAs) have been reported to be essential for (NAFLD progression. The pote...

    Authors: Xinlu Yuan, Yanyan Li, Song Wen, Chenglin Xu, Congcong Wang, Yanju He and Ligang Zhou
    Citation: Lipids in Health and Disease 2022 21:127
  6. Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction. Endothelial cell function is closely related t...

    Authors: Yali Lai, Yue Tian, Xintong You, Jiangnan Du and Jianmei Huang
    Citation: Lipids in Health and Disease 2022 21:101
  7. The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. There is increasing evidence that GDM is a heterogeneous disease with different subtypes. An important question in this context is...

    Authors: Moritz Liebmann, Katharina Grupe, Melissa Asuaje Pfeifer, Ingo Rustenbeck and Stephan Scherneck
    Citation: Lipids in Health and Disease 2022 21:99
  8. Although obesity is caused by different factors, individual susceptibility to obesity differs among people under the same circumstances. The microbiota in the caecum or fresh faeces and metabolites in blood or...

    Authors: Yueshan Pang, Yali Zheng, Ni Yang, Meng Zan, Lu Zhang and WeiJun Ding
    Citation: Lipids in Health and Disease 2022 21:98
  9. Rash, photosensitivity, erythema multiforme, and the acute generalized exanthematous pustulosis (AGEP) are relatively uncommon adverse reactions of drugs. To date, the etiology is not well understood and indiv...

    Authors: Markus Blaess, Lars Kaiser, Oliver Sommerfeld, René Csuk and Hans-Peter Deigner
    Citation: Lipids in Health and Disease 2021 20:156
  10. The relationship between nonalcoholic fatty liver disease (NAFLD) and obesity-related indices has been analyzed separately thus far, and evidence comparing these indices together is still lacking, especially i...

    Authors: Fangfei Xie, Yuyu Pei, Quan Zhou, Deli Cao and Yun Wang
    Citation: Lipids in Health and Disease 2021 20:132