BMC Infectious Diseases is calling for submissions to our Collection on Sepsis: pathogenesis, diagnosis, and treatment. Sepsis, a life-threatening condition resulting from the body's extreme response to infection, remains a leading cause of morbidity and mortality worldwide. Bloodstream infections, a common trigger for sepsis, can lead to severe complications, including septic shock and multiple organ failure. The Sepsis-3 definition has refined our understanding of this complex syndrome, emphasizing the importance of early recognition and timely intervention. Despite advances in diagnostic techniques and therapeutic strategies, sepsis continues to pose significant challenges in clinical practice, necessitating ongoing research to improve patient outcomes.
Advancing our collective understanding of sepsis is crucial for developing effective prevention and treatment strategies. Recent advances have included the identification of novel biomarkers for early diagnosis, the refinement of the Sequential Organ Failure Assessment (SOFA) score for risk stratification, and the exploration of targeted therapeutics. These developments have the potential to enhance clinical decision-making and improve survival rates. However, the complexity of sepsis demands further investigation into its pathophysiology, the role of host factors, and the impact of emerging pathogens, including fungal infections. Continued research in this area may lead to groundbreaking discoveries in personalized medicine approaches for sepsis management, including tailored therapeutic interventions based on individual patient profiles. Additionally, advancements in technology, such as artificial intelligence and machine learning, could revolutionize early detection and monitoring of sepsis, ultimately improving patient outcomes and reducing healthcare costs.
This Collection aims to enhance understanding and improve clinical practices in sepsis and bloodstream infections management. We welcome diverse contributions from basic research to clinical trials. Key topics of interest for submission include, but are not limited to:
- Biomarkers for sepsis diagnosis
- Therapeutics in septic shock management
- Fungal sepsis and its implications
- SOFA score and organ dysfunction assessment
- Multiple organ failure in sepsis patients
This Collection supports and amplifies research related to SDG 3: Good Health and Well-being.
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