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Single-cell analysis: toward the clinic

Guest editor: Michael Speicher

Rapid advances have been made in the separation, detection and analysis of genomic and proteomic material in single cells, and this approach is now beginning to inform our understanding and treatment of disease. Genome Medicine presents a series of articles devoted to single-cell analysis, with commissioned comment and review articles, and original research, providing a state-of-the-art overview of this fast moving area and its clinical applications.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The guest editor declares no competing interests.

  1. Tumor cells in the blood of patients with metastatic carcinomas are associated with poor survival. Knowledge of the cells’ genetic make-up can help to guide targeted therapy. We evaluated the efficiency and qu...

    Authors: Joost F Swennenhuis, Joke Reumers, Kim Thys, Jeroen Aerssens and Leon WMM Terstappen
    Citation: Genome Medicine 2013 5:106
    Content type: Research Published on:

  2. Strand-seq is a single-cell sequencing technique to finely map sister chromatid exchanges (SCEs) and other rearrangements. To analyze these data, we introduce BAIT, software which assigns templates and identif...

    Authors: Mark Hills, Kieran O’Neill, Ester Falconer, Ryan Brinkman and Peter M Lansdorp
    Citation: Genome Medicine 2013 5:82
    Content type: Software Published on:

  3. Single-cell functional proteomics assays can connect genomic information to biological function through quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly ...

    Authors: Wei Wei, Young Shik Shin, Chao Ma, Jun Wang, Meltem Elitas, Rong Fan and James R Heath
    Citation: Genome Medicine 2013 5:75
    Content type: Review Published on:

  5. For cancer patients, the current approach to prognosis relies on clinicopathological staging, but usually this provides little information about the individual response to treatment. Therefore, there is a trem...

    Authors: Ellen Heitzer, Martina Auer, Peter Ulz, Jochen B Geigl and Michael R Speicher
    Citation: Genome Medicine 2013 5:73
    Content type: Review Published on:

  7. Preimplantation genetic diagnosis (PGD) aims to help couples with heritable genetic disorders to avoid the birth of diseased offspring or the recurrence of loss of conception. Following in vitro fertilization, on...

    Authors: Niels Van der Aa, Masoud Zamani Esteki, Joris R Vermeesch and Thierry Voet
    Citation: Genome Medicine 2013 5:71
    Content type: Review Published on:

  10. Patients with prostate cancer may present with metastatic or recurrent disease despite initial curative treatment. The propensity of metastatic prostate cancer to spread to the bone has limited repeated sampli...

    Authors: Ellen Heitzer, Peter Ulz, Jelena Belic, Stefan Gutschi, Franz Quehenberger, Katja Fischereder, Theresa Benezeder, Martina Auer, Carina Pischler, Sebastian Mannweiler, Martin Pichler, Florian Eisner, Martin Haeusler, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg…
    Citation: Genome Medicine 2013 5:30
    Content type: Research Published on: