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Single-cell analysis: toward the clinic

Guest editor: Michael Speicher

Rapid advances have been made in the separation, detection and analysis of genomic and proteomic material in single cells, and this approach is now beginning to inform our understanding and treatment of disease. Genome Medicine presents a series of articles devoted to single-cell analysis, with commissioned comment and review articles, and original research, providing a state-of-the-art overview of this fast moving area and its clinical applications.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The guest editor declares no competing interests.

  1. Software

    BAIT: Organizing genomes and mapping rearrangements in single cells

    Strand-seq is a single-cell sequencing technique to finely map sister chromatid exchanges (SCEs) and other rearrangements. To analyze these data, we introduce BAIT, software which assigns templates and identif...

    Mark Hills, Kieran O’Neill, Ester Falconer, Ryan Brinkman and Peter M Lansdorp

    Genome Medicine 2013 5:82

    Published on: 13 September 2013

  2. Review

    Circulating tumor cells and DNA as liquid biopsies

    For cancer patients, the current approach to prognosis relies on clinicopathological staging, but usually this provides little information about the individual response to treatment. Therefore, there is a trem...

    Ellen Heitzer, Martina Auer, Peter Ulz, Jochen B Geigl and Michael R Speicher

    Genome Medicine 2013 5:73

    Published on: 23 August 2013

  3. Review

    Preimplantation genetic diagnosis guided by single-cell genomics

    Preimplantation genetic diagnosis (PGD) aims to help couples with heritable genetic disorders to avoid the birth of diseased offspring or the recurrence of loss of conception. Following in vitro fertilization, on...

    Niels Van der Aa, Masoud Zamani Esteki, Joris R Vermeesch and Thierry Voet

    Genome Medicine 2013 5:71

    Published on: 19 August 2013

  4. Research highlight

    Plasma-seq: a novel strategy for metastatic prostate cancer analysis

    Personalized genomics will only be useful for monitoring the prognosis of patients with cancer when it becomes much more cost-effective and quicker to apply. A recent study brings this closer to reality with t...

    Caitlin Farris and Jeffrey M Trimarchi

    Genome Medicine 2013 5:35

    Published on: 29 April 2013

  5. Research

    Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing

    Patients with prostate cancer may present with metastatic or recurrent disease despite initial curative treatment. The propensity of metastatic prostate cancer to spread to the bone has limited repeated sampli...

    Ellen Heitzer, Peter Ulz, Jelena Belic, Stefan Gutschi, Franz Quehenberger, Katja Fischereder, Theresa Benezeder, Martina Auer, Carina Pischler, Sebastian Mannweiler, Martin Pichler, Florian Eisner, Martin Haeusler, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg…

    Genome Medicine 2013 5:30

    Published on: 5 April 2013