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Simparica Trio

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This collection was created to facilitate access to manuscripts published in Parasites & Vectors focusing on Simparica Trio™.

Simparica Trio™ (sarolaner, moxidectin, and pyrantel chewable tablets) is a combination product for dogs with efficacy against both internal and external parasites. The three active ingredients in Simparica Trio provide comprehensive parasite protection against both internal and external parasites with the convenience of a single monthly chewable tablet.

The manuscripts in this collection contain data supporting the efficacy and safety of Simparica Trio for the prevention of heartworm and lungworm disease, the treatment and control of fleas and ticks and the treatment of common intestinal nematodes in dogs.

All manuscripts have undergone the journalʼs standard peer review process overseen by the Editors and each article can also be found individually in the journal. The Editors declare no competing interests.

The studies and journal charges for processing the manuscripts in the collection have been funded by Zoetis and a detailed conflict of interest is included within each article.

View all collections published in Parasites & Vectors

  1. Heartworm (Dirofilaria immitis) disease continues to increase and spread, remaining one of the most important and pathogenic parasitic diseases of dogs, despite the regular use of macrocyclic lactones (MLs) in pr...

    Authors: Molly D. Savadelis, Tom L. McTier, Kristina Kryda, Steven J. Maeder and Debra J. Woods
    Citation: Parasites & Vectors 2022 15:82
  2. Administration of four to six consecutive monthly doses of 24 µg/kg moxidectin alone shows high effectiveness in preventing the maturation of macrocyclic lactone (ML)-resistant heartworm strains, Dirofilaria immi...

    Authors: Jamie A. E. Myers, Susan Holzmer, John W. McCall, Sean P. Mahabir, Tom L. McTier, Steven J. Maeder and Kristina Kryda
    Citation: Parasites & Vectors 2022 15:81
  3. The Australian paralysis tick, Ixodes holocyclus, causes tick paralysis in dogs and cats in the eastern coastal regions of Australia. Prevention is the best option to protect dogs against this potentially fatal d...

    Authors: Raj Packianathan, Andrew Hodge, Natalie Bruellke, Chrissie Jackson and Steven Maeder
    Citation: Parasites & Vectors 2020 13:448
  4. Infection with the cardiopulmonary nematode Angiostrongylus vasorum may cause severe disease in dogs, therefore prophylactic treatments are necessary to prevent infection in dogs at risk. A clinical field study w...

    Authors: Csilla Becskei, Jakob L. Willesen, Manuela Schnyder, Magda Wozniakiewicz, Nataliya Miroshnikova and Sean P. Mahabir
    Citation: Parasites & Vectors 2020 13:385
  5. Recent reports indicated that increasing the monthly oral dosage and the number of consecutive monthly doses of moxidectin improved the efficacy against macrocyclic lactone (ML)-resistant Dirofilaria immitis. The...

    Authors: Kristina Kryda, Susan Holzmer, William R. Everett, John W. McCall, Sean P. Mahabir, Tom L. McTier and Steven J. Maeder
    Citation: Parasites & Vectors 2020 13:339
  6. Tick infestations can cause direct deleterious effects to dogs as a result of tick blood-feeding, and indirectly ticks can transmit disease agents that can be detrimental to the health of both dogs and humans....

    Authors: Csilla Becskei, Julian Liebenberg, Mirjan Thys and Sean P. Mahabir
    Citation: Parasites & Vectors 2020 13:100
  7. Ancylostomatids (‘hookworms’) are among the most important zoonotic nematode parasites infecting dogs worldwide. Ancylostoma caninum and Uncinaria stenocephala are two of the most common hookworm species that inf...

    Authors: Csilla Becskei, Mirjan Thys, Kristina Kryda, Leon Meyer, Susanna Martorell, Thomas Geurden, Leentje Dreesen, Tiago Fernandes and Sean P. Mahabir
    Citation: Parasites & Vectors 2020 13:99
  8. One randomized, controlled clinical field study was conducted in 18 general veterinary practices throughout the USA to evaluate the safety and efficacy of a novel oral chewable combination tablet, Simparica Tr...

    Authors: Kristina Kryda, Sean P. Mahabir, Tammy Inskeep and Jady Rugg
    Citation: Parasites & Vectors 2020 13:98
  9. The efficacy of a novel oral combination product, Simparica Trio™, containing sarolaner, moxidectin and pyrantel was evaluated against five tick species that commonly infest dogs in the USA, Amblyomma americanum,...

    Authors: Kristina Kryda, Sean P. Mahabir, Sara Chapin, Susan J. Holzmer, Laurel Bowersock, William R. Everett, John Riner, Lori Carter and David Young
    Citation: Parasites & Vectors 2020 13:77
  10. The black-legged (or deer) tick, Ixodes scapularis, commonly infests dogs in the USA and is the vector of important zoonotic pathogens, including Borrelia burgdorferi, the causative agent of Lyme disease. Rapid o...

    Authors: Susan Holzmer, Kristina Kryda, Sean P. Mahabir and William Everett
    Citation: Parasites & Vectors 2020 13:76
  11. A novel chewable oral tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) has recently been developed to provide persistent protection against flea and tick infections for a month, treatment...

    Authors: Csilla Becskei, Daphne Fias, Sean P. Mahabir and Robert Farkas
    Citation: Parasites & Vectors 2020 13:72
  12. Ascarid infections are among the most prevalent intestinal parasitic infections occurring in dogs around the world, with Toxocara canis and Toxascaris leonina commonly observed. Toxocara canis can cause considera...

    Authors: Csilla Becskei, Kristina Kryda, Mirjan Thys, Susan Holzmer, Laurel Bowersock, Tiago Fernandes, Leon Meyer, Craig Reinemeyer and Sean P. Mahabir
    Citation: Parasites & Vectors 2020 13:71
  13. Gastrointestinal nematodes are parasites that commonly infect dogs, and infections can be subclinical or may cause considerable clinical disease. Some species are zoonotic and may also cause clinical disease i...

    Authors: Csilla Becskei, Kristina Kryda, Daphne Fias, Stacey L. Follis, Magda Wozniakiewicz, Sean P. Mahabir and Robert Farkas
    Citation: Parasites & Vectors 2020 13:70
  14. Infection with Angiostrongylus vasorum may cause severe clinical disease, even death in dogs, however, due to the often non-specific clinical signs, diagnosis is not always straightforward. Regular prophylactic t...

    Authors: Csilla Becskei, Mirjan Thys, Padraig Doherty and Sean P. Mahabir
    Citation: Parasites & Vectors 2020 13:64
  15. Five studies were conducted to evaluate a novel oral combination tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™), for efficacy against induced flea infestations, speed of kill and effect...

    Authors: Kristina Kryda, Sean P. Mahabir, Lori Carter, William R. Everett, David R. Young, Leon Meyer, Mirjan Thys, Sara Chapin, Susan J. Holzmer and Csilla Becskei
    Citation: Parasites & Vectors 2020 13:57
  16. Dirofilaria immitis is a filarial parasite of dogs that can cause serious or fatal cardiopulmonary disease. Three studies were conducted to evaluate the efficacy and safety of monthly treatment with moxidectin in...

    Authors: Kristina Kryda, Robert H. Six, Kelly F. Walsh, Susan J. Holzmer, Sara Chapin, Sean P. Mahabir, Melanie Myers, Tammy Inskeep, Jady Rugg, Blair Cundiff, Aleah Pullins, Michael Ulrich, John W. McCall, Tom L. McTier and Steven J. Maeder
    Citation: Parasites & Vectors 2019 12:445
  17. Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Three studies were co...

    Authors: Tom L. McTier, Robert H. Six, Aleah Pullins, Sara Chapin, Kristina Kryda, Sean P. Mahabir, Debra J. Woods and Steven J. Maeder
    Citation: Parasites & Vectors 2019 12:444