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Simparica Trio

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This collection was created to facilitate access to manuscripts published in Parasites & Vectors focusing on Simparica Trio™.

Simparica Trio™ (sarolaner, moxidectin, and pyrantel chewable tablets) is a combination product for dogs with efficacy against both internal and external parasites. The three active ingredients in Simparica Trio provide comprehensive parasite protection against both internal and external parasites with the convenience of a single monthly chewable tablet.

The manuscripts in this collection contain data supporting the efficacy and safety of Simparica Trio for the prevention of heartworm and lungworm disease, the treatment and control of fleas and ticks and the treatment of common intestinal nematodes in dogs.

All manuscripts have undergone the journalʼs standard peer review process overseen by the Editors and each article can also be found individually in the journal. The Editors declare no competing interests.

The studies and journal charges for processing the manuscripts in the collection have been funded by Zoetis and a detailed conflict of interest is included within each article.

View all collections published in Parasites & Vectors

  1. Tick infestations can cause direct deleterious effects to dogs as a result of tick blood-feeding, and indirectly ticks can transmit disease agents that can be detrimental to the health of both dogs and humans....

    Authors: Csilla Becskei, Julian Liebenberg, Mirjan Thys and Sean P. Mahabir

    Citation: Parasites & Vectors 2020 13:100

    Content type: Research

    Published on:

  2. Ancylostomatids (‘hookworms’) are among the most important zoonotic nematode parasites infecting dogs worldwide. Ancylostoma caninum and Uncinaria stenocephala are two of the most common hookworm species that inf...

    Authors: Csilla Becskei, Mirjan Thys, Kristina Kryda, Leon Meyer, Susanna Martorell, Thomas Geurden, Leentje Dreesen, Tiago Fernandes and Sean P. Mahabir

    Citation: Parasites & Vectors 2020 13:99

    Content type: Research

    Published on:

  3. One randomized, controlled clinical field study was conducted in 18 general veterinary practices throughout the USA to evaluate the safety and efficacy of a novel oral chewable combination tablet, Simparica Tr...

    Authors: Kristina Kryda, Sean P. Mahabir, Tammy Inskeep and Jady Rugg

    Citation: Parasites & Vectors 2020 13:98

    Content type: Research

    Published on:

  4. The efficacy of a novel oral combination product, Simparica Trio™, containing sarolaner, moxidectin and pyrantel was evaluated against five tick species that commonly infest dogs in the USA, Amblyomma americanum,...

    Authors: Kristina Kryda, Sean P. Mahabir, Sara Chapin, Susan J. Holzmer, Laurel Bowersock, William R. Everett, John Riner, Lori Carter and David Young

    Citation: Parasites & Vectors 2020 13:77

    Content type: Research

    Published on:

  5. The black-legged (or deer) tick, Ixodes scapularis, commonly infests dogs in the USA and is the vector of important zoonotic pathogens, including Borrelia burgdorferi, the causative agent of Lyme disease. Rapid o...

    Authors: Susan Holzmer, Kristina Kryda, Sean P. Mahabir and William Everett

    Citation: Parasites & Vectors 2020 13:76

    Content type: Short report

    Published on:

  6. A novel chewable oral tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) has recently been developed to provide persistent protection against flea and tick infections for a month, treatment...

    Authors: Csilla Becskei, Daphne Fias, Sean P. Mahabir and Robert Farkas

    Citation: Parasites & Vectors 2020 13:72

    Content type: Research

    Published on:

  7. Ascarid infections are among the most prevalent intestinal parasitic infections occurring in dogs around the world, with Toxocara canis and Toxascaris leonina commonly observed. Toxocara canis can cause considera...

    Authors: Csilla Becskei, Kristina Kryda, Mirjan Thys, Susan Holzmer, Laurel Bowersock, Tiago Fernandes, Leon Meyer, Craig Reinemeyer and Sean P. Mahabir

    Citation: Parasites & Vectors 2020 13:71

    Content type: Research

    Published on:

  8. Gastrointestinal nematodes are parasites that commonly infect dogs, and infections can be subclinical or may cause considerable clinical disease. Some species are zoonotic and may also cause clinical disease i...

    Authors: Csilla Becskei, Kristina Kryda, Daphne Fias, Stacey L. Follis, Magda Wozniakiewicz, Sean P. Mahabir and Robert Farkas

    Citation: Parasites & Vectors 2020 13:70

    Content type: Research

    Published on:

  9. Infection with Angiostrongylus vasorum may cause severe clinical disease, even death in dogs, however, due to the often non-specific clinical signs, diagnosis is not always straightforward. Regular prophylactic t...

    Authors: Csilla Becskei, Mirjan Thys, Padraig Doherty and Sean P. Mahabir

    Citation: Parasites & Vectors 2020 13:64

    Content type: Research

    Published on:

  10. Five studies were conducted to evaluate a novel oral combination tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™), for efficacy against induced flea infestations, speed of kill and effect...

    Authors: Kristina Kryda, Sean P. Mahabir, Lori Carter, William R. Everett, David R. Young, Leon Meyer, Mirjan Thys, Sara Chapin, Susan J. Holzmer and Csilla Becskei

    Citation: Parasites & Vectors 2020 13:57

    Content type: Research

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  11. Dirofilaria immitis is a filarial parasite of dogs that can cause serious or fatal cardiopulmonary disease. Three studies were conducted to evaluate the efficacy and safety of monthly treatment with moxidectin in...

    Authors: Kristina Kryda, Robert H. Six, Kelly F. Walsh, Susan J. Holzmer, Sara Chapin, Sean P. Mahabir, Melanie Myers, Tammy Inskeep, Jady Rugg, Blair Cundiff, Aleah Pullins, Michael Ulrich, John W. McCall, Tom L. McTier and Steven J. Maeder

    Citation: Parasites & Vectors 2019 12:445

    Content type: Research

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  12. Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Three studies were co...

    Authors: Tom L. McTier, Robert H. Six, Aleah Pullins, Sara Chapin, Kristina Kryda, Sean P. Mahabir, Debra J. Woods and Steven J. Maeder

    Citation: Parasites & Vectors 2019 12:444

    Content type: Research

    Published on: