Skip to content

Advertisement

You're viewing the new version of our site. Please leave us feedback.

Learn more

SimparicaTM: Comparative Efficacy of sarolaner, a novel oral ectoparasiticide for dogs

Simparica™ (Sarolaner ) is the most recently approved product in the isoxazoline class of parasiticides for dogs. As a class, the isoxazolines offer broad spectrum activity against fleas, and ticks following oral administration. They have a rapid onset of activity against existing infestations and also provide excellent protection due to their sustained activity.


Fleas and ticks are vectors of numerous pathogens, and the rapid interruption of flea and tick feeding is critical to reducing the risk of their transmission. The parasiticides in any given class of products, including isoxazolines, are not identical in performance: individual compounds have different profiles in spectrum of activity, speed of kill, and duration and consistency of protection. These factors should be considered by the veterinarian and pet owner in selecting the right product for each pet based on the coverage they provide, the pet’s lifestyle, risk of vector-borne pathogens and other relevant factors.
Presented here is a collection of papers comparing the efficacy of sarolaner with other commonly used flea and tick control products, both topical and oral, at various time points after treatment and after re-infestation over the approved dosing intervals. These comparisons allow an evidence-based evaluation of the relative onset of effect, speed of action and duration and consistency of protection these products provide against flea and ticks throughout the dosing interval.


The articles in this collection were peer reviewed following the journal’s standard processes and each article can be found individually in the journal. These studies and the article production charges were funded by Zoetis and a detailed conflict of interest statement is included in each article.

View all collections published in Parasites & Vectors

  1. Content type: Research

    Canine babesiosis is a clinically significant emerging vector-borne disease caused among others by the protozoan Babesia canis. The efficacy of sarolaner (Simparica®; Zoetis; at the minimum recommended label dose...

    Authors: Thomas Geurden, Robert Six, Csilla Becskei, Steven Maeder, Anne Lloyd, Sean Mahabir, Josephus Fourie and Julian Liebenberg

    Citation: Parasites & Vectors 2017 10:415

    Published on:

  2. Content type: Research

    Amblyomma cajennense is the main vector of Rickettsia rickettsii which causes Brazilian spotted fever. This adult tick preferably infests horses and capybaras, but has low host specifi...

    Authors: Fabio Scott, Lilian Franz, Diefrey Ribeiro Campos, Thaís Ribeiro Correia Azevedo, Daise Cunha, Robert H. Six, Steven Maeder and Travis Cree

    Citation: Parasites & Vectors 2017 10:390

    Published on:

  3. Content type: Research

    The Australian paralysis tick, Ixodes holocyclus, causes paralysis predominantly in dogs and cats in the Eastern coastal regions of Australia. Rapid onset of effect of a parasiticide is critical to minimize the d...

    Authors: Raj Packianathan, Andrew Hodge, Natalie Bruellke, Kylie Davis and Steven Maeder

    Citation: Parasites & Vectors 2017 10:98

    Published on:

  4. Content type: Research

    The lone star tick, Amblyomma americanum, infests dogs and cats in North America and transmits the pathogens Ehrlichia chaffeensis and Ehrlichia ewingii, which cause monocytic and granulocytic ehrlichiosis in dog...

    Authors: Robert H. Six, David R. Young, Melanie R. Myers and Sean P. Mahabir

    Citation: Parasites & Vectors 2016 9:399

    Published on:

  5. Content type: Research

    Rhipicephalus sanguineus is the most widely distributed tick species infesting dogs worldwide, which may cause discomfort to the host and transmit diseases. Acaricides with a rapid and...

    Authors: Csilla Becskei, Thomas Geurden, Julian Liebenberg, Otto Cuppens, Sean P. Mahabir and Robert H. Six

    Citation: Parasites & Vectors 2016 9:103

    Published on:

  6. Content type: Research

    Ticks are common ectoparasites that infest dogs globally. Acaricides with rapid and sustained speed of kill are critical to control infestations and to reduce the risk of disease transmission. This study evalu...

    Authors: Csilla Becskei, Thomas Geurden, Heidi Erasmus, Otto Cuppens, Sean P. Mahabir and Robert H. Six

    Citation: Parasites & Vectors 2016 9:104

    Published on:

  7. Content type: Research

    Fleas are the most common ectoparasite infesting dogs globally and cause direct discomfort, induce allergic reactions, and transmit pathogenic agents. Rapid speed of kill is an important characteristic for a p...

    Authors: Robert H. Six, Julian Liebenberg, Nicole A. Honsberger and Sean P. Mahabir

    Citation: Parasites & Vectors 2016 9:92

    Published on:

  8. Content type: Research

    The brown dog tick, Rhipicephalus sanguineus sensu lato, commonly infests dogs globally, is the major vector of the pathogen that causes canine monocytic ehrlichiosis and also transmits Babesia vogeli. A rapid sp...

    Authors: Robert H. Six, David R. Young, Susan J. Holzmer and Sean P. Mahabir

    Citation: Parasites & Vectors 2016 9:91

    Published on:

  9. Content type: Research

    The lone star tick, Amblyomma americanum, infests dogs and cats in North America and is the vector of the pathogens that cause monocytic and granulocytic ehrlichiosis in dogs and humans. A parasiticide’s speed of...

    Authors: Robert H. Six, William R. Everett, Sara Chapin and Sean P. Mahabir

    Citation: Parasites & Vectors 2016 9:98

    Published on:

  10. Content type: Research

    Fleas are the most common ectoparasite infesting dogs globally. The many possible sequellae of infestation include: direct discomfort; allergic reactions; and the transmission of pathogens. Rapid speed of kill...

    Authors: Robert H. Six, Julian Liebenberg, Nicole A. Honsberger and Sean P. Mahabir

    Citation: Parasites & Vectors 2016 9:90

    Published on:

  11. Content type: Research

    Fleas are a ubiquitous ectoparasite infesting dogs and cause direct discomfort, allergic reactions and are responsible for the transmission of several pathogens. The rapid speed of kill of a parasiticide is im...

    Authors: Robert H. Six, William R. Everett, Melanie R. Myers and Sean P. Mahabir

    Citation: Parasites & Vectors 2016 9:93

    Published on:

  12. Content type: Research

    The black-legged (or deer) tick, Ixodes scapularis, commonly infests dogs and cats in North America and is the main vector for the pathogen that causes Lyme disease in dogs and humans. The speed of kill of a para...

    Authors: Robert H. Six, David R. Young, Melanie R. Myers and Sean P. Mahabir

    Citation: Parasites & Vectors 2016 9:79

    Published on:

Advertisement