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Key signalling nodes in mammary gland development and cancer

Adrian Lee and Charles Streuli

  1. Content type: Review

    Although uncommon, breast cancer in young women is worthy of special attention due to the unique and complex issues that are raised. This article reviews specific challenges associated with the care of younger...

    Authors: Courtney A Gabriel and Susan M Domchek

    Citation: Breast Cancer Research 2010 12:212

    Published on:

  2. Content type: Review

    Breast cancer is the most common cancer among women, and despite significant advances in diagnosing and treating it, metastatic spread of cancer cells results in a high mortality rate. Epithelial-to-mesenchyma...

    Authors: Ellen Foubert, Bram De Craene and Geert Berx

    Citation: Breast Cancer Research 2010 12:206

    Published on:

  3. Content type: Review

    The protein serine/threonine kinase Akt, also known as protein kinase B (PKB), is arguably the most important signalling nexus in the cell. Akt integrates a plethora of extracellular signals to generate divers...

    Authors: Julie A Wickenden and Christine J Watson

    Citation: Breast Cancer Research 2010 12:202

    Published on:

  4. Content type: Review

    Seven classes of mitogen-activated protein kinase (MAPK) intracellular signalling cascades exist, four of which are implicated in breast disease and function in mammary epithelial cells. These are the extracel...

    Authors: Jacqueline Whyte, Orla Bergin, Alessandro Bianchi, Sara McNally and Finian Martin

    Citation: Breast Cancer Research 2009 11:209

    Published on: