Edited by Norman Davey
Short linear motifs (SLiMs) guide the life of proteins from translation to destruction, directing their interactions, modification state, localisation and stability. The human proteome has been estimated to contain more than a hundred thousand – possibly up to a million – SLiM instances. Yet, to date, only a small fraction of the complete motif repertoire has been characterised and we still know relatively little about these elegantly simple protein interaction modules. This review series in Cell Communication and Signaling explores several central concepts that have emerged in the field of protein motif biology and, in doing so, highlights key questions about SLiMs that still remain to be answered.
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer review process. The Guest Editor declares no competing interests.
RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RN...