Skip to main content

Advertisement

Sex Differences in Obesity, Insulin Resistance, Metabolic Syndrome, and the Microbiome

About the series

New data show that there are sex differences in the mechanisms responsible for insulin resistance, metabolic syndrome and obesity.  Furthermore, sex differences are also present in the gut microbiome which is important in maintaining levels of estrogens and androgens. The cardiometabolic consequences of sex differences in these tissues impact the development and prognosis for cardiovascular disease in men and women.

For these reasons, the Editors of Biology of Sex Differences have commissioned this thematic series on Sex Differences in Obesity, Insulin Resistance, Metabolic Syndrome and the Microbiome. This collection of commissioned review articles and original research papers provides an overview of what is known about sex differences as they relate to cardiometabolic health and obesity.  

  1. Accumulating evidence indicates that high-fat diet (HFD)-induced metabolic disorders are associated with dysbiosis of the gut microbiota. However, the sex-specific characteristics of the gut microbiota and its...

    Authors: Chao Peng, Xinbo Xu, Yanshu Li, Xueyang Li, Xiaoyu Yang, Hongyan Chen, Yin Zhu, Nonghua Lu and Cong He

    Citation: Biology of Sex Differences 2020 11:5

    Content type: Research

    Published on:

  2. Diabetes is a strong risk factor for vascular disease. There is compelling evidence that the relative risk of vascular disease associated with diabetes is substantially higher in women than men. The mechanisms...

    Authors: Rianneke de Ritter, Marit de Jong, Rimke C. Vos, Carla J. H. van der Kallen, Simone J. S. Sep, Mark Woodward, Coen D. A. Stehouwer, Michiel L. Bots and Sanne A. E. Peters

    Citation: Biology of Sex Differences 2020 11:1

    Content type: Review

    Published on:

  3. Placental ischemia and hypertension, characteristic features of preeclampsia, are associated with impaired cerebral blood flow (CBF) autoregulation and cerebral edema. However, the factors that contribute to t...

    Authors: Junie P. Warrington, Fan Fan, Jeremy Duncan, Mark W. Cunningham, Babette B. LaMarca, Ralf Dechend, Gerd Wallukat, Richard J. Roman, Heather A. Drummond, Joey P. Granger and Michael J. Ryan

    Citation: Biology of Sex Differences 2019 10:58

    Content type: Research

    Published on:

  4. Males and females exhibit significant differences in metabolism and in brain ischemic stroke and different features of brain ischemic lesions are related to different health outcomes. It is critical to underst...

    Authors: Hailuan Zeng, Weibin Shi, Wenhai Jiang, Shengxiang Rao, Beijian Huang, Hongmei Yan and Xin Gao

    Citation: Biology of Sex Differences 2019 10:40

    Content type: Research

    Published on:

  5. Angiotensin-(1-7) is a beneficial hormone of the renin-angiotensin system known to play a positive role in regulation of blood pressure and glucose homeostasis. Previous studies have shown that in high-fat die...

    Authors: Melissa C. White, Amanda J. Miller, Justin Loloi, Sarah S. Bingaman, Biyi Shen, Ming Wang, Yuval Silberman, Sarah H. Lindsey and Amy C. Arnold

    Citation: Biology of Sex Differences 2019 10:36

    Content type: Research

    Published on:

  6. Although some recent studies have indicated an association between metabolic syndrome (MetS) and musculoskeletal disease, little is known about the association of MetS with low back pain (LBP). The present stu...

    Authors: Takahiko Yoshimoto, Hirotaka Ochiai, Takako Shirasawa, Satsue Nagahama, Akihito Uehara, Shogo Sai and Akatsuki Kokaze

    Citation: Biology of Sex Differences 2019 10:33

    Content type: Research

    Published on:

  7. It is well documented that the metabolic syndrome predisposes patients to increased cardiovascular risk. Emerging data indicates that cardiovascular risk conferred by metabolic syndrome is highly dependent on ...

    Authors: Jessica L. Faulkner and Eric J. Belin de Chantemèle

    Citation: Biology of Sex Differences 2019 10:30

    Content type: Review

    Published on:

  8. Key differences exist between men and women in the determinants and manifestations of cardiovascular and cardiometabolic diseases. Recently, gut microbiome-host relations have been implicated in cardiovascular...

    Authors: Alexander C. Razavi, Kaitlin S. Potts, Tanika N. Kelly and Lydia A. Bazzano

    Citation: Biology of Sex Differences 2019 10:29

    Content type: Review

    Published on:

  9. Adipocytes and macrophages, the two major constituents of adipose tissue, exhibit sex differences and work in synergy in adipose tissue physiology and pathophysiology, including obesity-linked insulin resistan...

    Authors: Yang Xin Zi Xu, Geetika Bassi and Suresh Mishra

    Citation: Biology of Sex Differences 2019 10:25

    Content type: Review

    Published on:

  10. Weight loss by surgery or lifestyle changes is strongly recommended for obese individuals to improve metabolic health, but the underlying impairments that persist from a history of obesity remain unclear. Rece...

    Authors: Cameron Griffin, Chelsea R. Hutch, Simin Abrishami, Daria Stelmak, Leila Eter, Ziru Li, Eric Chang, Devyani Agarwal, Brian Zamarron, Mita Varghese, Perla Subbaiah, Ormond A. MacDougald, Darleen A. Sandoval and Kanakadurga Singer

    Citation: Biology of Sex Differences 2019 10:16

    Content type: Research

    Published on: