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World Sepsis Day 2017

2017 marks 15 years since the creation of the Surviving Sepsis Campaign, 10 years of the Sepsis Alliance and 5 years of World Sepsis Day, held annually on 13th September.

BioMed Central journals Critical Care, Journal of Intensive Care, Scandinavian Journal of Trauma Resuscitation and Emergency Medicine, Antimicrobial Resistance & Infection Control, Annals of Clinical Microbiology and Antimicrobials, Microbiome, Burns & Trauma, BMC Pediatrics, Military Medical Research and BMC Infectious Diseases are all leading the way in making sepsis research available to a global audience.

To celebrate all that has been achieved in improving awareness, diagnosis and treatment of sepsis in this time, we present you with a collection of research articles, reviews, commentaries and editorials important to furthering sepsis research.

You can also read our recent blog post by Marijke Vroomen Durning of the Sepsis Alliance:
Sepsis Awareness Month – Suspect sepsis. Save lives.

  1. Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause meta...

    Authors: Ali Hassoun, Peter K. Linden and Bruce Friedman
    Citation: Critical Care 2017 21:211
    Content type: Review Published on:

  2. Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical int...

    Authors: Sonja Hamed, Michael Behnes, Dominic Pauly, Dominic Lepiorz, Max Barre, Tobias Becher, Siegfried Lang, Ibrahim Akin, Martin Borggrefe, Thomas Bertsch and Ursula Hoffmann
    Citation: BMC Infectious Diseases 2017 17:554
    Content type: Research article Published on:

  4. Sepsis is one of the leading causes of mortality among children worldwide. Unfortunately, however, reliable evidence was insufficient in pediatric sepsis and many aspects in clinical practice actually depend o...

    Authors: Tatsuya Kawasaki
    Citation: Journal of Intensive Care 2017 5:47
    Content type: Review Published on:

  5. Late onset sepsis (LOS) in preterm infants is associated with considerable morbidity and mortality. While studies have implicated gut bacteria in the aetiology of the disease, functional analysis and mechanist...

    Authors: Christopher J. Stewart, Nicholas D. Embleton, Emma C. L. Marrs, Daniel P. Smith, Tatiana Fofanova, Andrew Nelson, Tom Skeath, John D. Perry, Joseph F. Petrosino, Janet E. Berrington and Stephen P. Cummings
    Citation: Microbiome 2017 5:75
    Content type: Research Published on:

  6. Patients with severe sepsis generally respond well to initial therapy administered in the emergency department (ED), but a subset later decompensate and require unexpected transfer to the intensive care unit (...

    Authors: Gabriel Wardi, Arvin R. Wali, Julian Villar, Vaishal Tolia, Christian Tomaszewski, Christian Sloane, Peter Fedullo, Jeremy R. Beitler, Matthew Nolan, Daniel Lasoff and Rebecca E. Sell
    Citation: Journal of Intensive Care 2017 5:43
    Content type: Research Published on:

  7. Neonatal bloodstream infection (BSI) is the most important cause of morbidity and mortality in the neonatal intensive care unit (NICU). Although most neonatal BSIs are primary bacteremia, some are associated w...

    Authors: I-Hsyuan Wu, Ming-Horng Tsai, Mei-Yin Lai, Lee-Fen Hsu, Ming-Chou Chiang, Reyin Lien, Ren-Huei Fu, Hsuan-Rong Huang, Shih-Ming Chu and Jen-Fu Hsu
    Citation: BMC Infectious Diseases 2017 17:465
    Content type: Research article Published on:

  8. Blood stream infections (BSI) are critical medical conditions with high morbidity and mortality. There is paucity of information on BSI from surveillance studies in Ghana.

    Authors: Japheth Awuletey Opintan and Mercy Jemima Newman
    Citation: Antimicrobial Resistance & Infection Control 2017 6:64
    Content type: Research Published on:

  9. Compared to developed countries, the use of antimicrobials in Egypt is less regulated and is available over the counter without the need for prescriptions. The impact of such policy on antimicrobial resistance...

    Authors: Lamiaa Mohsen, Nermin Ramy, Dalia Saied, Dina Akmal, Niveen Salama, Mona M. Abdel Haleim and Hany Aly
    Citation: Antimicrobial Resistance & Infection Control 2017 6:63
    Content type: Research Published on:

  10. We aimed to evaluate the clinical usefulness of qSOFA as a risk stratification tool for patients admitted with infection compared to traditional SIRS criteria or our triage system; the Rapid Emergency Triage a...

    Authors: Åsa Askim, Florentin Moser, Lise T. Gustad, Helga Stene, Maren Gundersen, Bjørn Olav Åsvold, Jostein Dale, Lars Petter Bjørnsen, Jan Kristian Damås and Erik Solligård
    Citation: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:56
    Content type: Original research Published on:

  12. A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis...

    Authors: Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Alessandro Jenkner, Sara Balduzzi, Francesca Calò Carducci, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Giorgia Copponi, Alessandra Simonetti, Elena Ferretti, Valeria Di Franco, Virginia Rasi, Martina Della Corte…
    Citation: BMC Infectious Diseases 2017 17:302
    Content type: Research article Published on:

  13. Although tissue perfusion is often decreased in patients with sepsis, the relationship between macrohemodynamics and microcirculatory blood flow is poorly understood. We hypothesized that alterations in retina...

    Authors: Kristo Erikson, Janne Henrik Liisanantti, Nina Hautala, Juha Koskenkari, Remi Kamakura, Karl Heinz Herzig, Hannu Syrjälä and Tero Ilmari Ala-Kokko
    Citation: Critical Care 2017 21:86
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2017 21:148

  14. Patients with bloodstream infections (BSI) are associated with high mortality rates. Due to tigecycline has shown excellent in vitro activity against most pathogens, tigecycline is selected as one of the candi...

    Authors: Jian Wang, Yaping Pan, Jilu Shen and Yuanhong Xu
    Citation: Annals of Clinical Microbiology and Antimicrobials 2017 16:24
    Content type: Review Published on:

  16. Polyethylene glycol (PEG) is widely used for bowel cleaning in preparation for colonoscopy because of its safety. Septic shock after PEG preparation is an extremely rare complication. Herein, we describe a cas...

    Authors: Tetsuya Yumoto, Yoshiyasu Kono, Seiji Kawano, Chihiro Kamoi, Atsuyoshi Iida, Motoko Nose, Keiji Sato, Toyomu Ugawa, Hiroyuki Okada, Yoshihito Ujike and Atsunori Nakao
    Citation: Annals of Clinical Microbiology and Antimicrobials 2017 16:22
    Content type: Case report Published on:

  17. Newborns are a population in which antibiotic consumption is extremely high. Targeted antibiotic therapy should help to reduce antibiotics consumption. The aim of this study was an assessment of antibiotic usa...

    Authors: A. Różańska, J. Wójkowska-Mach, P. Adamski, M. Borszewska-Kornacka, E. Gulczyńska, M. Nowiczewski, E. Helwich, A. Kordek, D. Pawlik and M. Bulanda
    Citation: Annals of Clinical Microbiology and Antimicrobials 2017 16:20
    Content type: Research Published on:

  18. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA...

    Authors: Eli J. Finkelsztein, Daniel S. Jones, Kevin C. Ma, Maria A. Pabón, Tatiana Delgado, Kiichi Nakahira, John E. Arbo, David A. Berlin, Edward J. Schenck, Augustine M. K. Choi and Ilias I. Siempos
    Citation: Critical Care 2017 21:73
    Content type: Research Published on:

  19. Fluid therapy is a common and crucial treatment in the emergency department (ED). While fluid responsiveness seems to be a promising method to titrate fluid therapy, the evidence for its value in ED is unclear...

    Authors: Mohammed H. Elwan, Ashraf Roshdy, Eman M. Elsharkawy, Salah M. Eltahan and Timothy J. Coats
    Citation: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:25
    Content type: Review Published on:

  20. Current sepsis screening tools rely on vital parameters which are, however, normal in one third of patients with serious infections. Therefore, there is a need to include other variables than vital parameters ...

    Authors: Ulrika Margareta Wallgren, Katarina Eva Margareta Bohm and Lisa Kurland
    Citation: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:23
    Content type: Original research Published on:

  21. Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...

    Authors: Takeshi Suzuki, Yuta Suzuki, Jun Okuda, Takuya Kurazumi, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata and Hiroshi Morisaki
    Citation: Journal of Intensive Care 2017 5:22
    Content type: Review Published on:

  22. Sepsis remains a major clinical problem with high morbidity and mortality. As new inflammatory mediators are characterized, it is important to understand their roles in sepsis. Interleukin 33 (IL-33) is a rece...

    Authors: Hui Xu, Heth R. Turnquist, Rosemary Hoffman and Timothy R. Billiar
    Citation: Military Medical Research 2017 4:3
    Content type: Review Published on:

  23. Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less...

    Authors: Malvin Torsvik, Lise Tuset Gustad, Arne Mehl, Inger Lise Bangstad, Liv Jorun Vinje, Jan Kristian Damås and Erik Solligård
    Citation: Critical Care 2016 20:244
    Content type: Research Published on:

    The Editorial to this article has been published in Critical Care 2017 21:10

  25. Sepsis is the focus of national quality improvement programs and a recent public reporting measure from the Centers for Medicare and Medicaid Services. However, diagnosing sepsis requires interpreting nonspeci...

    Authors: Chanu Rhee, Sameer S. Kadri, Robert L. Danner, Anthony F. Suffredini, Anthony F. Massaro, Barrett T. Kitch, Grace Lee and Michael Klompas
    Citation: Critical Care 2016 20:89
    Content type: Research Published on: