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World Sepsis Day 2017

2017 marks 15 years since the creation of the Surviving Sepsis Campaign, 10 years of the Sepsis Alliance and 5 years of World Sepsis Day, held annually on 13th September.

BioMed Central journals Critical Care, Journal of Intensive Care, Scandinavian Journal of Trauma Resuscitation and Emergency MedicineAntimicrobial Resistance & Infection Control, Annals of Clinical Microbiology and Antimicrobials, Microbiome, Burns & Trauma, BMC Pediatrics, Military Medical Research and BMC Infectious Diseases are all leading the way in making sepsis research available to a global audience.

To celebrate all that has been achieved in improving awareness, diagnosis and treatment of sepsis in this time, we present you with a collection of research articles, reviews, commentaries and editorials important to furthering sepsis research.

You can also read our recent blog post by Marijke Vroomen Durning of the Sepsis Alliance:
Sepsis Awareness Month – Suspect sepsis. Save lives.

  1. Research article

    Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions

    Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical int...

    Sonja Hamed, Michael Behnes, Dominic Pauly, Dominic Lepiorz, Max Barre, Tobias Becher, Siegfried Lang, Ibrahim Akin, Martin Borggrefe, Thomas Bertsch and Ursula Hoffmann

    BMC Infectious Diseases 2017 17:554

    Published on: 9 August 2017

  2. Review

    Update on pediatric sepsis: a review

    Sepsis is one of the leading causes of mortality among children worldwide. Unfortunately, however, reliable evidence was insufficient in pediatric sepsis and many aspects in clinical practice actually depend o...

    Tatsuya Kawasaki

    Journal of Intensive Care 2017 5:47

    Published on: 20 July 2017

  3. Research

    Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls

    Late onset sepsis (LOS) in preterm infants is associated with considerable morbidity and mortality. While studies have implicated gut bacteria in the aetiology of the disease, functional analysis and mechanist...

    Christopher J. Stewart, Nicholas D. Embleton, Emma C. L. Marrs, Daniel P. Smith, Tatiana Fofanova, Andrew Nelson, Tom Skeath, John D. Perry, Joseph F. Petrosino, Janet E. Berrington and Stephen P. Cummings

    Microbiome 2017 5:75

    Published on: 12 July 2017

  4. Research

    Unexpected intensive care transfer of admitted patients with severe sepsis

    Patients with severe sepsis generally respond well to initial therapy administered in the emergency department (ED), but a subset later decompensate and require unexpected transfer to the intensive care unit (...

    Gabriel Wardi, Arvin R. Wali, Julian Villar, Vaishal Tolia, Christian Tomaszewski, Christian Sloane, Peter Fedullo, Jeremy R. Beitler, Matthew Nolan, Daniel Lasoff and Rebecca E. Sell

    Journal of Intensive Care 2017 5:43

    Published on: 12 July 2017

  5. Research article

    Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus

    Neonatal bloodstream infection (BSI) is the most important cause of morbidity and mortality in the neonatal intensive care unit (NICU). Although most neonatal BSIs are primary bacteremia, some are associated w...

    I-Hsyuan Wu, Ming-Horng Tsai, Mei-Yin Lai, Lee-Fen Hsu, Ming-Chou Chiang, Reyin Lien, Ren-Huei Fu, Hsuan-Rong Huang, Shih-Ming Chu and Jen-Fu Hsu

    BMC Infectious Diseases 2017 17:465

    Published on: 3 July 2017

  6. Research

    Emerging antimicrobial resistance in early and late-onset neonatal sepsis

    Compared to developed countries, the use of antimicrobials in Egypt is less regulated and is available over the counter without the need for prescriptions. The impact of such policy on antimicrobial resistance...

    Lamiaa Mohsen, Nermin Ramy, Dalia Saied, Dina Akmal, Niveen Salama, Mona M. Abdel Haleim and Hany Aly

    Antimicrobial Resistance & Infection Control 2017 6:63

    Published on: 13 June 2017

  7. Original research

    Poor performance of quick-SOFA (qSOFA) score in predicting severe sepsis and mortality – a prospective study of patients admitted with infection to the emergency department

    We aimed to evaluate the clinical usefulness of qSOFA as a risk stratification tool for patients admitted with infection compared to traditional SIRS criteria or our triage system; the Rapid Emergency Triage a...

    Åsa Askim, Florentin Moser, Lise T. Gustad, Helga Stene, Maren Gundersen, Bjørn Olav Åsvold, Jostein Dale, Lars Petter Bjørnsen, Jan Kristian Damås and Erik Solligård

    Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:56

    Published on: 9 June 2017

  8. Research article

    Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis

    A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis...

    Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Alessandro Jenkner, Sara Balduzzi, Francesca Calò Carducci, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Giorgia Copponi, Alessandra Simonetti, Elena Ferretti, Valeria Di Franco, Virginia Rasi, Martina Della Corte…

    BMC Infectious Diseases 2017 17:302

    Published on: 24 April 2017

  9. Research

    Retinal arterial blood flow and retinal changes in patients with sepsis: preliminary study using fluorescein angiography

    Although tissue perfusion is often decreased in patients with sepsis, the relationship between macrohemodynamics and microcirculatory blood flow is poorly understood. We hypothesized that alterations in retina...

    Kristo Erikson, Janne Henrik Liisanantti, Nina Hautala, Juha Koskenkari, Remi Kamakura, Karl Heinz Herzig, Hannu Syrjälä and Tero Ilmari Ala-Kokko

    Critical Care 2017 21:86

    Published on: 10 April 2017

    The Commentary to this article has been published in Critical Care 2017 21:148

  10. Research article

    Prevention of neonatal late-onset sepsis: a randomised controlled trial

    Late-onset sepsis (LOS), defined as sepsis occurring after 48 h of age causes substantial mortality and morbidity in very low birth weight infants. Risk factors for LOS include immaturity, intravascular cathet...

    Gary Alcock, Helen G. Liley, Lucy Cooke and Peter H. Gray

    BMC Pediatrics 2017 17:98

    Published on: 4 April 2017

  11. Case report

    Citrobacter braakii bacteremia-induced septic shock after colonoscopy preparation with polyethylene glycol in a critically ill patient: a case report

    Polyethylene glycol (PEG) is widely used for bowel cleaning in preparation for colonoscopy because of its safety. Septic shock after PEG preparation is an extremely rare complication. Herein, we describe a cas...

    Tetsuya Yumoto, Yoshiyasu Kono, Seiji Kawano, Chihiro Kamoi, Atsuyoshi Iida, Motoko Nose, Keiji Sato, Toyomu Ugawa, Hiroyuki Okada, Yoshihito Ujike and Atsunori Nakao

    Annals of Clinical Microbiology and Antimicrobials 2017 16:22

    Published on: 4 April 2017

  12. Research

    Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland

    Newborns are a population in which antibiotic consumption is extremely high. Targeted antibiotic therapy should help to reduce antibiotics consumption. The aim of this study was an assessment of antibiotic usa...

    A. Różańska, J. Wójkowska-Mach, P. Adamski, M. Borszewska-Kornacka, E. Gulczyńska, M. Nowiczewski, E. Helwich, A. Kordek, D. Pawlik and M. Bulanda

    Annals of Clinical Microbiology and Antimicrobials 2017 16:20

    Published on: 31 March 2017

  13. Research

    Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit

    The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA...

    Eli J. Finkelsztein, Daniel S. Jones, Kevin C. Ma, Maria A. Pabón, Tatiana Delgado, Kiichi Nakahira, John E. Arbo, David A. Berlin, Edward J. Schenck, Augustine M. K. Choi and Ilias I. Siempos

    Critical Care 2017 21:73

    Published on: 26 March 2017

  14. Review

    The haemodynamic dilemma in emergency care: Is fluid responsiveness the answer? A systematic review

    Fluid therapy is a common and crucial treatment in the emergency department (ED). While fluid responsiveness seems to be a promising method to titrate fluid therapy, the evidence for its value in ED is unclear...

    Mohammed H. Elwan, Ashraf Roshdy, Eman M. Elsharkawy, Salah M. Eltahan and Timothy J. Coats

    Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:25

    Published on: 6 March 2017

  15. Review

    Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis

    Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...

    Takeshi Suzuki, Yuta Suzuki, Jun Okuda, Takuya Kurazumi, Tomohiro Suhara, Tomomi Ueda, Hiromasa Nagata and Hiroshi Morisaki

    Journal of Intensive Care 2017 5:22

    Published on: 3 March 2017

  16. Original research

    Presentations of adult septic patients in the prehospital setting as recorded by emergency medical services: a mixed methods analysis

    Current sepsis screening tools rely on vital parameters which are, however, normal in one third of patients with serious infections. Therefore, there is a need to include other variables than vital parameters ...

    Ulrika Margareta Wallgren, Katarina Eva Margareta Bohm and Lisa Kurland

    Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:23

    Published on: 3 March 2017

  17. Review

    Role of the IL-33-ST2 axis in sepsis

    Sepsis remains a major clinical problem with high morbidity and mortality. As new inflammatory mediators are characterized, it is important to understand their roles in sepsis. Interleukin 33 (IL-33) is a rece...

    Hui Xu, Heth R. Turnquist, Rosemary Hoffman and Timothy R. Billiar

    Military Medical Research 2017 4:3

    Published on: 2 February 2017

  18. Research

    Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival

    Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less...

    Malvin Torsvik, Lise Tuset Gustad, Arne Mehl, Inger Lise Bangstad, Liv Jorun Vinje, Jan Kristian Damås and Erik Solligård

    Critical Care 2016 20:244

    Published on: 5 August 2016

    The Editorial to this article has been published in Critical Care 2017 21:10

  19. Research

    Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes

    Sepsis is the focus of national quality improvement programs and a recent public reporting measure from the Centers for Medicare and Medicaid Services. However, diagnosing sepsis requires interpreting nonspeci...

    Chanu Rhee, Sameer S. Kadri, Robert L. Danner, Anthony F. Suffredini, Anthony F. Massaro, Barrett T. Kitch, Grace Lee and Michael Klompas

    Critical Care 2016 20:89

    Published on: 6 April 2016