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Spreading Depolarization in Headache Disorders

Edited by:
Professor Shih-Pin Chen, MD, PhD, Taipei Veterans General Hospital, Taiwan
Professor Cenk Ayata, MD, PhD, Harvard Medical School, United States of America

Submission Status: Open   |   Submission Deadline: 30 September 2024

The Journal of Headache and Pain is calling for submissions to our Collection on Spreading Depolarization in Headache Disorders.

Image credits: © Kateryna_Kon /

Meet the Guest Editors

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Professor Shih-Pin Chen, MD, PhD, Taipei Veterans General Hospital, Taiwan

Dr. Shih-Pin Chen, a physician-scientist, is currently the Chief of Division of Translational Research at Taipei Veterans General Hospital and a Professor at National Yang Ming Chiao Tung University. Dedicated to the study of headaches and neurovascular diseases, Dr. Chen employs a multi-faceted research approach, integrating clinical expertise, neuroimaging, genomics, and animal models. He has authored over 150 research articles and textbook chapters. Dr. Chen has served as an Associate Editor of The Journal of Headache and Pain since 2023, the Secretary General of the Asia Regional Consortium of Headache, and a member of the Science and Research Committee of the International Headache Society.

Professor Cenk Ayata, MD, PhD, Harvard Medical School, USA

Dr. Cenk Ayata is a Professor of Neurology at the Massachusetts General Hospital and Harvard Medical School and the Director of the Neurovascular Research Unit. As a physician-scientist, Dr. Ayata's research straddles translational efforts to understand neurovascular function and dysfunction, focusing on ischemic and hemorrhagic brain injuries, cerebral small vessel disease, and migraine. His laboratory uses electrophysiological and multimodal optical imaging techniques in animal models of ischemic or hemorrhagic brain injury and migraine to dissect pathophysiology and test therapeutic interventions. His work has been supported by the NIH, AHA, Leducq Foundation, industry, private non-profit foundations, and philanthropy. In over 200 peer-reviewed articles, his most notable contributions have been spreading depolarizations in brain injury and migraine, preclinical testing of stroke and migraine therapeutics, and multicenter preclinical stroke trials.

About the Collection

Characterized by profound neuronal and glial depolarization, spreading depolarization (SD) orchestrates a cascade of metabolic and hemodynamic consequences. The relationship between SD and a spectrum of disorders, particularly migraine, unfolds a compelling yet complex narrative. Within the confines of this Collection, we invite researchers, clinicians, and academicians to traverse with us through the multifaceted domain of SD, exploring its mechanisms, relevance, and implications in both primary and secondary neurological disorders, thereby crafting a harmonious comprehension amidst the dissonance of existing theories and findings.

The realm of SD sparks compelling debates: Is canonical SD a clinically pertinent model of migraine, or is it a culprit of meningeal nociceptor activation? We invite experts to partake in debates that scrutinize the involvement and clinical relevance of SD, dissecting its role in the orchestration of migraine and illuminating the pathways of pain emanating from meningeal nociceptors. Comprehensive reviews unraveling the mechanisms of neuroinflammation in SD as well as its implications in primary and secondary neurological disorders are highly anticipated. We also welcome original articles traversing the horizons of SD, investigating its mechanistic pathways and clinical implications. Special emphasis on studies that delve into not only the causative facets of SD but also its consequences, therapeutic potentials, and predictive capabilities are particularly encouraged.

Through the meticulous construction of this article Collection, we aspire to weave together threads of understanding, questions, and novel insights regarding SD. We anticipate a vibrant confluence of diverse perspectives and robust research, fostering a rich scientific discourse and unraveling the mysteries enshrouding spreading depolarization.

  1. Neurogenic meningeal inflammation is regarded as a key driver of migraine headache. Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the lep...

    Authors: Anna A. Karan, Konstantin A. Gerasimov, Yulia S. Spivak, Elena M. Suleymanova and Lyudmila V. Vinogradova
    Citation: The Journal of Headache and Pain 2024 25:113

Submission Guidelines

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This Collection welcomes submission of original research articles, debate/controversies, and reviews. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. 

Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Spreading Depolarization in Headache Disorders" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.