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Stem cells and gene editing

Edited by Stephen H. Tsang

A thematic series in Stem Cell Research & Therapy

13287-020-01964-5 © vchalup /

Stem cells have captivated scientists and researchers due the ability to regenerate dying or damaged cells. A wide variety of stem cells including hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), and, most recently, induced pluripotent stem cells (iPSC) allow for extensive disease modeling and therapeutic testing possibilities. With the advent of gene editing techniques in the 1980s and further refinement leading to CRISPR/Cas9, base editing, and prime editing, the potential for stem cell therapy in inherited genetic diseases is now closer than ever before. With these advancements, the possibility of autologous stem cell transplantation combining patient-derived iPSCs and gene editing may be realized.

This thematic series aims to highlight the latest developments in gene editing as it pertains to stem cell therapy in a variety of fields and specialties. All article types are welcome, from research to review.

  1. Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both. Some of these rare diseases are caused by aberration...

    Authors: C. Eguizabal, L. Herrera, M. Inglés-Ferrándiz and J. C. Izpisua Belmonte
    Citation: Stem Cell Research & Therapy 2020 11:453

    The Correction to this article has been published in Stem Cell Research & Therapy 2021 12:250

  2. Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies usi...

    Authors: Keerthana Shankar, Christian M. Capitini and Krishanu Saha
    Citation: Stem Cell Research & Therapy 2020 11:234