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Sudden cardiac death - advances in diagnosis and treatment

Guest Editor: Dr Federico Guerra (Marche Polytechnic University, Ancona, Italy)

Despite recent advances in technology and improved awareness, sudden cardiac death is still a major cause of death worldwide. With this thematic series, we wanted to help focus on the grey areas that still linger and provide new evidence with a wide range of papers. From molecular autopsy, device-detected data, "real-world" data to innovative technology, this collection merges many important research groups to provide a good aerial view on the topic, from bench to bedside.

Read the below, published content in this thematic series covering all aspects of research into advancing the "Diagnosis and Treatment of Sudden Cardiac Death".

  1. Platelet activation plays a crucial role in the pathogenesis of coronary artery disease (CAD). Platelet P-selectin (CD62P) is a classic platelet activation indicator on the platelet surface, and soluble TREM-l...

    Authors: Li Shen, Tianlun Yang, Ke Xia, Zhiqiang Yan, Juanjuan Tan, Lei Li, Yingchun Qin and Wei Shi
    Citation: BMC Cardiovascular Disorders 2020 20:387
    Content type: Research article Published on:

  2. Danon disease (OMIM 300257) is an X-linked lysosomal storage disorder, characterized by hypertrophic cardiomyopathy (HCM), skeletal myopathy, variable intellectual disability, and other minor clinical features.

    Authors: Valeria Novelli, Antonio Bisignani, Gemma Pelargonio, Guido Primiano, Maria Lucia Narducci, Vincenzo Palmieri, Francesco Danilo Tiziano, Paolo Zeppilli, Serenella Servidei, Filippo Crea and Maurizio Genuardi
    Citation: BMC Cardiovascular Disorders 2020 20:156
    Content type: Case report Published on:

  3. Arrhythmogenic cardiomyopathy (AC) is one of the leading causes for sudden cardiac death (SCD). Recent studies have identified mutations in cardiac desmosomes as key players in the pathogenesis of AC. However,...

    Authors: Xiaoping Lin, Yuankun Ma, Zhejun Cai, Qiyuan Wang, Lihua Wang, Zhaoxia Huo, Dan Hu, Jian’an Wang and Meixiang Xiang
    Citation: BMC Cardiovascular Disorders 2020 20:74
    Content type: Research article Published on:

  4. Coronary heart disease is related to sudden death caused by multi-factors and a major threat to human health.This study explores the role of OX40L and ICAM-1 in the stability of coronary plaques and their rela...

    Authors: Yu Wang, Xiaoyu Sun, Bing Xia, Cuiyun Le, Zhu Li, Jie Wang, Jiang Huang, Jiawen Wang and Changwu Wan
    Citation: BMC Cardiovascular Disorders 2019 19:272
    Content type: Research article Published on:

  5. Pulmonary embolism (PE) is associated to high mortality rate worldwide. However, the diagnosis of PE often results inaccurate. Many cases of PE are incorrectly diagnosed or missed and they are often associated...

    Authors: Gelsomina Mansueto, Dario Costa, Emanuele Capasso, Federica Varavallo, Giuseppina Brunitto, Rosanna Caserta, Salvatore Esposito, Massimo Niola, Celestino Sardu, Raffaele Marfella, Claudio Napoli and Mariano Paternoster
    Citation: BMC Cardiovascular Disorders 2019 19:250
    Content type: Research article Published on:

  6. Because of previous ventricular arrhythmia (VA) episodes, patients with implantable cardioverter-defibrillator (ICD) for secondary prevention (SP) are generally considered to have a higher burden of VAs than p...

    Authors: You Zhou, Shuang Zhao, Keping Chen, Wei Hua, Yangang Su, Silin Chen, Zhaoguang Liang, Wei Xu and Shu Zhang
    Citation: BMC Cardiovascular Disorders 2019 19:230
    Content type: Research article Published on:

  7. We aimed to determine the mutation yield and clinical applicability of “molecular autopsy” following sudden arrhythmic death syndrome (SADS) by validating and utilizing low-cost high-throughput technologies: F...

    Authors: Hariharan Raju, James S. Ware, Jonathan R. Skinner, Paula L. Hedley, Gavin Arno, Donald R. Love, Christian van der Werf, Jacob Tfelt-Hansen, Bo Gregers Winkel, Marta C. Cohen, Xinzhong Li, Shibu John, Sanjay Sharma, Steve Jeffery, Arthur A. M. Wilde, Michael Christiansen…
    Citation: BMC Cardiovascular Disorders 2019 19:174
    Content type: Research article Published on:

  8. Little is known about the ICD performance using enhanced detection algorithms in unselected, non-trial patients. Performance of recent generation ICD equipped with SmartShock™ technology (SST) for detection an...

    Authors: François Regoli, Denis Graf, Beat Schaer, Firat Duru, Peter Ammann, Lorenza Mangoni di S. Stefano, Barbara Naegli, Haran Burri, Rainer Zbinden, Nazmi Krasniqi and Martin Fromer
    Citation: BMC Cardiovascular Disorders 2019 19:146
    Content type: Research article Published on:

  9. Gamma-glutamyltransferase (GGT) is a new predictor of cardiovascular diseases. In this study, we aimed to determine its association with ventricular arrhythmias (VAs) in implantable cardioverter-defibrillator ...

    Authors: You Zhou, Shuang Zhao, Keping Chen, Wei Hua and Shu Zhang
    Citation: BMC Cardiovascular Disorders 2019 19:129
    Content type: Research article Published on:

  10. Arrhythmic sudden cardiac death (SCD) represents a major worldwide public health problem accounting for 15–20% of deaths. Risk stratification to identify patients at risk of SCD is crucial in order to implemen...

    Authors: C. Balla, F. Vitali, A. Brieda, F. Gualandi, A. Ferlini, M. Bertini and R. Ferrari
    Citation: BMC Cardiovascular Disorders 2019 19:104
    Content type: Review Published on:

  11. Hypertrophic cardiomyopathy (HCM) is a myocardial disease. However, the coexistence of HCM with muscular ventricular septal defect (VSD), especially those with both incomplete spontaneous closure and coronary ...

    Authors: Guang-mei Zheng, Jiao Bai, Jun-ming Tang, Fang-cheng Zhu and Hong-xia Jing
    Citation: BMC Cardiovascular Disorders 2019 19:16
    Content type: Case report Published on:

  12. There are limited data about modes of death and major adverse cardiovascular events (MACEs) in patients with hypertrophic cardiomyopathy (HCM) in South East Asian population. The aim of the study was to examin...

    Authors: Nattakorn Songsirisuk, Veraprapas Kittipibul, Nilubon Methachittiphan, Vorawan Charoenattasil, Nath Zungsontiporn, Ittikorn Spanuchart, Saranya Buppajarntham, Charoen Mankongpaisarnrung, Sudarat Satitthummanid, Suphot Srimahachota, Pairoj Chattranukulchai, Smonporn Boonyaratavej Songmuang and Sarinya Puwanant
    Citation: BMC Cardiovascular Disorders 2019 19:1
    Content type: Research article Published on:

  13. Implantable cardioverter defibrillator (ICD) implantation is associated with driving restrictions which may have profound effects on the patient’s life. However, there is limited patient-reported data on the i...

    Authors: Jenny Bjerre, Simone Hofman Rosenkranz, Anne Mielke Christensen, Morten Schou, Christian Jøns, Gunnar Gislason and Anne-Christine Ruwald
    Citation: BMC Cardiovascular Disorders 2018 18:212
    Content type: Research article Published on:

  14. In Denmark and other countries, there has been a shift in the management of patients with an implantable cardioverter defibrillator (ICD) with remote device monitoring largely replacing in-hospital visits. Les...

    Authors: Susanne S. Pedersen, Søren J. Skovbakke, Uffe K. Wiil, Thomas Schmidt, Rene dePont Christensen, Carl J. Brandt, Jan Sørensen, Michael Vinther, Charlotte E. Larroudé, Thomas M. Melchior, Sam Riahi, Kim G. E. Smolderen, John A. Spertus, Jens B. Johansen and Jens C. Nielsen
    Citation: BMC Cardiovascular Disorders 2018 18:136
    Content type: Study protocol Published on:

  15. Transmural acute myocardial infarction (AMI) is associated with a high risk for ventricular arrhythmia before, during and after treatment. Consequently, it is recommended that patients diagnosed with transmura...

    Authors: Marco Albanese, Korhan Alpaslan, Taoufik Ouarrak, Peter Merguet, Steffen Schneider and Wolfgang Schöls
    Citation: BMC Cardiovascular Disorders 2018 18:116
    Content type: Research article Published on:

  16. The wearable cardioverter-defibrillator (WCD) has emerged as a valuable tool to temporarily protect patients at risk for sudden cardiac death (SCD). The aim of this study was to determine the value of the WCD ...

    Authors: Susanne Röger, Stefanie L. Rosenkaimer, Anna Hohneck, Siegfried Lang, Ibrahim El-Battrawy, Boris Rudic, Erol Tülümen, Ksenija Stach, Jürgen Kuschyk, Ibrahim Akin and Martin Borggrefe
    Citation: BMC Cardiovascular Disorders 2018 18:52
    Content type: Research article Published on: