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Call for papers: The roles of intrinsically disordered proteins and regions (IDPs and IDRs) in cell communication and cell signaling

The roles of intrinsically disordered proteinsEdited by
Sarah Bondos,Texas A&M University, USA
A. K. Dunker, Indiana University, USA
Vladimir Uversky, University of South Florida, USA

Cell Communications and Signaling invites you to submit to our new thematic series: The roles of intrinsically disordered proteins and regions (IDPs and IDRs) in cell communication and cell signaling.

Intrinsically disordered proteins and regions (IDPs and IDRs) are of crucial importance to cell communication and signaling. IDRs increase the complexity of regulatory networks by combining a wider range of protein interactions with alternative splicing and post-translational modification to elicit unique cellular outcomes.  Indeed, harnessing the power of cell signaling for applications in biotechnology will require understanding and engineering the roles of IDPs and IDRs in the various signaling pathways and in the environments in which they operate.  Our upcoming special issue explores many cell signaling pathways and their applications in light of recent advances in the field of intrinsic disorder.  Topics include chemical signaling, sensing and responding to temperature, pressure, and light.  Also included are the roles of disorder in designing sensors, switches, and scaffolds for tissue engineering. 

We welcome the submission of additional manuscripts that describe the functional roles of IDPs or IDRs in cell communication and signaling.

Submission Deadline: July 1, 2021 (new)
Submit your research here. 

  1. Signal fidelity depends on protein–protein interaction–‘hubs’ integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-h...

    Authors: Lasse Staby, Katrine Bugge, Rasmus Greve Falbe-Hansen, Edoardo Salladini, Karen Skriver and Birthe B. Kragelund

    Citation: Cell Communication and Signaling 2021 19:2

    Content type: Commentary

    Published on:

  2. The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates. These substrates include, but are not limited to...

    Authors: Trevor P. Creamer

    Citation: Cell Communication and Signaling 2020 18:137

    Content type: Review

    Published on:

  3. Metabolites produced via traditional biochemical processes affect intracellular communication, inflammation, and malignancy. Unexpectedly, acetyl-CoA, α-ketoglutarate and palmitic acid, which are chemical spec...

    Authors: Ioannis Skalidis, Christian Tüting and Panagiotis L. Kastritis

    Citation: Cell Communication and Signaling 2020 18:136

    Content type: Review

    Published on:

  4. Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the inside of cells. Remarkably, they orchestrate key biological processes...

    Authors: Pernille Seiffert, Katrine Bugge, Mads Nygaard, Gitte W. Haxholm, Jacob H. Martinsen, Martin N. Pedersen, Lise Arleth, Wouter Boomsma and Birthe B. Kragelund

    Citation: Cell Communication and Signaling 2020 18:132

    Content type: Research

    Published on:

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