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The roles of intrinsically disordered proteins and regions (IDPs and IDRs) in cell communication and cell signaling

The roles of intrinsically disordered proteinsEdited by
Sarah Bondos,Texas A&M University, USA
A. K. Dunker, Indiana University, USA
Vladimir Uversky, University of South Florida, USA

Intrinsically disordered proteins and regions (IDPs and IDRs) are of crucial importance to cell communication and signaling. IDRs increase the complexity of regulatory networks by combining a wider range of protein interactions with alternative splicing and post-translational modification to elicit unique cellular outcomes.  Indeed, harnessing the power of cell signaling for applications in biotechnology will require understanding and engineering the roles of IDPs and IDRs in the various signaling pathways and in the environments in which they operate.  This special issue explores many cell signaling pathways and their applications in light of recent advances in the field of intrinsic disorder.  Our collection consists of thirteen papers covering topics including chemical signaling, sensing and responding to temperature, pressure, and light.  Also included are the roles of disorder in designing sensors, switches, and scaffolds for tissue engineering. 

It is clear that articles assembled into this special issue only scratched the tip of the iceberg and many important questions related to the role of intrinsic disorder in regulation of cell signaling and communication are waiting to be asked and answered. Cell Communication and Signaling encourages additional submissions on this research topic. If you believe that you can add to one or more questions related to this subject, please to submit your manuscript to become a part of this thematic series.

  1. Signaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca2+ or chemokine proteins) and physical stimuli (e.g., sheer stress, light). Together, these pathways form an extensive co...

    Authors: Sarah E. Bondos, A. Keith Dunker and Vladimir N. Uversky
    Citation: Cell Communication and Signaling 2022 20:20
  2. For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured pro...

    Authors: Sarah E. Bondos, A. Keith Dunker and Vladimir N. Uversky
    Citation: Cell Communication and Signaling 2021 19:88
  3. Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization. Proteins that drive the f...

    Authors: Ryan J. Emenecker, Alex S. Holehouse and Lucia C. Strader
    Citation: Cell Communication and Signaling 2021 19:65
  4. CP12 is a small chloroplast protein that is widespread in various photosynthetic organisms and is an actor of the redox signaling pathway involved in the regulation of the Calvin Benson Bassham (CBB) cycle. Th...

    Authors: Hui Shao, Wenmin Huang, Luisana Avilan, Véronique Receveur-Bréchot, Carine Puppo, Rémy Puppo, Régine Lebrun, Brigitte Gontero and Hélène Launay
    Citation: Cell Communication and Signaling 2021 19:38
  5. The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy. Abl also is a critical regulator of normal development, playing c...

    Authors: Edward M. Rogers, S. Colby Allred and Mark Peifer
    Citation: Cell Communication and Signaling 2021 19:27
  6. Signal fidelity depends on protein–protein interaction–‘hubs’ integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-h...

    Authors: Lasse Staby, Katrine Bugge, Rasmus Greve Falbe-Hansen, Edoardo Salladini, Karen Skriver and Birthe B. Kragelund
    Citation: Cell Communication and Signaling 2021 19:2
  7. The circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced organismal survival by facilitating the anticipation of the day/night cycl...

    Authors: Jacqueline F. Pelham, Jay C. Dunlap and Jennifer M. Hurley
    Citation: Cell Communication and Signaling 2020 18:181
  8. The Drosophila melanogaster Germ cell-expressed protein (GCE) is a paralog of the juvenile hormone (JH) receptor - Methoprene tolerant protein (MET). Both proteins mediate JH function, preventing precocious diffe...

    Authors: Marta Kolonko, Dominika Bystranowska, Michał Taube, Maciej Kozak, Mark Bostock, Grzegorz Popowicz, Andrzej Ożyhar and Beata Greb-Markiewicz
    Citation: Cell Communication and Signaling 2020 18:180
  9. The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates. These substrates include, but are not limited to...

    Authors: Trevor P. Creamer
    Citation: Cell Communication and Signaling 2020 18:137
  10. Metabolites produced via traditional biochemical processes affect intracellular communication, inflammation, and malignancy. Unexpectedly, acetyl-CoA, α-ketoglutarate and palmitic acid, which are chemical spec...

    Authors: Ioannis Skalidis, Christian Tüting and Panagiotis L. Kastritis
    Citation: Cell Communication and Signaling 2020 18:136
  11. Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the inside of cells. Remarkably, they orchestrate key biological processes...

    Authors: Pernille Seiffert, Katrine Bugge, Mads Nygaard, Gitte W. Haxholm, Jacob H. Martinsen, Martin N. Pedersen, Lise Arleth, Wouter Boomsma and Birthe B. Kragelund
    Citation: Cell Communication and Signaling 2020 18:132