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Regenerative Medicine and Epigenetics

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Collection closed for submissions
 

Edited by Adele Murrell and Peter Rugg-Gunn

 Clinical Epigenetics is proud to present this new series, An inevitable outcome upon aging or in certain diseases is the progressive decline in tissue function. A goal of regenerative medicine is to restore normal function through tissue repair or replacement. These complex processes are closely linked to epigenetics because the deterioration in epigenetic safeguards can lead to the loss of tissue homeostasis. Conversely, modulating the epigenome can be exploited to control gene function and cell state with functional consequences on cell differentiation and regeneration. In this new thematic series, we examine key concepts in the interplay between regenerative medicine and the multiple layers of epigenetic regulation.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

Please find out more about our journal and its policies, here. Submission guidelines can be found here, and please submit to the series via our submission system (there will be a field for which you can indicate if you are submitting to this series).


  1. Therapeutic replacement of pancreatic endocrine β-cells is key to improving hyperglycaemia caused by insulin-dependent diabetes . Whilst the pool of ductal progenitors, which give rise to the endocrine cells, ...

    Authors: Safiya Naina Marikar, Keith Al-Hasani, Ishant Khurana, Harikrishnan Kaipananickal, Jun Okabe, Scott Maxwell and Assam El-Osta
    Citation: Clinical Epigenetics 2023 15:101
    Content type: Research Published on:

  2. The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algo...

    Authors: A. Mongelli, S. Panunzi, M. Nesta, M. Gottardi Zamperla, S. Atlante, V. Barbi, V. Mongiardini, F. Ferraro, S. De Martino, L. Cis, A. Re, S. Maltese, T. Bachetti, M. T. La Rovere, F. Martelli, M. Pesce…
    Citation: Clinical Epigenetics 2023 15:53
    Content type: Research Published on:

  3. It has been suggested that antenatal exposure to environmental endocrine disruptors is responsible for adverse trends in male reproductive health, including male infertility, impaired semen quality, cryptorchi...

    Authors: Ludwig Stenz, Matthias Beyens, Mark E. Gill, Ariane Paoloni-Giacobino and Christian De Geyter
    Citation: Clinical Epigenetics 2022 14:185
    Content type: Research Published on:

  4. Nanopore sequencing has brought the technology to the next generation in the science of sequencing. This is achieved through research advancing on: pore efficiency, creating mechanisms to control DNA transloca...

    Authors: Yohannis Wondwosen Ahmed, Berhan Ababaw Alemu, Sisay Addisu Bekele, Solomon Tebeje Gizaw, Muluken Fekadie Zerihun, Endriyas Kelta Wabalo, Maria Degef Teklemariam, Tsehayneh Kelemu Mihrete, Endris Yibru Hanurry, Tensae Gebru Amogne, Assaye Desalegne Gebrehiwot, Tamirat Nida Berga, Ebsitu Abate Haile, Dessiet Oma Edo and Bizuwork Derebew Alemu
    Citation: Clinical Epigenetics 2022 14:107
    Content type: Review Published on:

  5. Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing th...

    Authors: Daniel J. Simpson, Nelly N. Olova and Tamir Chandra
    Citation: Clinical Epigenetics 2021 13:170
    Content type: Review Published on: