Reviews

This list will be updated with all our new Reviews. Genome Medicine publishes Reviews that are open access and therefore free to read and share.

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The emerging role of viral vectors as vehicles for DMD gene editing

Duchenne muscular dystrophy (DMD) is a genetic disorder caused by mutations in the dystrophin-encoding DMD gene. The DMD gene, spanning over 2.4 megabases along the short arm of the X chromosome (Xp21.2), is the ...

Authors: Ignazio Maggio, Xiaoyu Chen and Manuel A. F. V. Gonçalves

Citation: Genome Medicine 2016 8:59

Content type: Review Published on: 23 May 2016
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The healthy human microbiome

Humans are virtually identical in their genetic makeup, yet the small differences in our DNA give rise to tremendous phenotypic diversity across the human population. By contrast, the metagenome of the human m...

Authors: Jason Lloyd-Price, Galeb Abu-Ali and Curtis Huttenhower

Citation: Genome Medicine 2016 8:51

Content type: Review Published on: 27 April 2016
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Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions

Mass spectrometry- and nuclear magnetic resonance-based metabolomic studies comparing diseased versus healthy individuals have shown that microbial metabolites are often the compounds most markedly altered in ...

Authors: Linda S. Zhang and Sean S. Davies

Citation: Genome Medicine 2016 8:46

Content type: Review Published on: 21 April 2016
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Impact of the gut microbiota on inflammation, obesity, and metabolic disease

The human gut harbors more than 100 trillion microbial cells, which have an essential role in human metabolic regulation via their symbiotic interactions with the host. Altered gut microbial ecosystems have be...

Authors: Claire L. Boulangé, Ana Luisa Neves, Julien Chilloux, Jeremy K. Nicholson and Marc-Emmanuel Dumas

Citation: Genome Medicine 2016 8:42

Content type: Review Published on: 20 April 2016
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Microbiome mediation of infections in the cancer setting

Infections encountered in the cancer setting may arise from intensive cancer treatments or may result from the cancer itself, leading to risk of infections through immune compromise, disruption of anatomic bar...

Authors: Ying Taur and Eric G. Pamer

Citation: Genome Medicine 2016 8:40

Content type: Review Published on: 18 April 2016
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The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

The widespread use of antibiotics in the past 80 years has saved millions of human lives, facilitated technological progress and killed incalculable numbers of microbes, both pathogenic and commensal. Human-as...

Authors: Amy Langdon, Nathan Crook and Gautam Dantas

Citation: Genome Medicine 2016 8:39

Content type: Review Published on: 13 April 2016
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Epigenetic impact of infection on carcinogenesis: mechanisms and applications

Viral and bacterial infections are involved in the development of human cancers, such as liver, nasopharyngeal, cervical, head and neck, and gastric cancers. Aberrant DNA methylation is frequently present in t...

Authors: Naoko Hattori and Toshikazu Ushijima

Citation: Genome Medicine 2016 8:10

Content type: Review Published on: 28 January 2016
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Landscape of gene fusions in epithelial cancers: seq and ye shall find

Enabled by high-throughput sequencing approaches, epithelial cancers across a range of tissue types are seen to harbor gene fusions as integral to their landscape of somatic aberrations. Although many gene fus...

Authors: Chandan Kumar-Sinha, Shanker Kalyana-Sundaram and Arul M. Chinnaiyan

Citation: Genome Medicine 2015 7:129

Content type: Review Published on: 18 December 2015
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Practical guidelines for B-cell receptor repertoire sequencing analysis

High-throughput sequencing of B-cell immunoglobulin repertoires is increasingly being applied to gain insights into the adaptive immune response in healthy individuals and in those with a wide range of disease...

Authors: Gur Yaari and Steven H. Kleinstein

Citation: Genome Medicine 2015 7:121

Content type: Review Published on: 20 November 2015
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Metagenomic cross-talk: the regulatory interplay between immunogenomics and the microbiome

The human microbiome, often referred to as the ‘second genome’, encompasses up to 100-fold more genes than the host genome. In contrast to the human genome, the microbial genome is flexible and amenable to cha...

Authors: Maayan Levy, Christoph A. Thaiss and Eran Elinav

Citation: Genome Medicine 2015 7:120

Content type: Review Published on: 20 November 2015
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Immunoinformatics and epitope prediction in the age of genomic medicine

Immunoinformatics involves the application of computational methods to immunological problems. Prediction of B- and T-cell epitopes has long been the focus of immunoinformatics, given the potential translation...

Authors: Linus Backert and Oliver Kohlbacher

Citation: Genome Medicine 2015 7:119

Content type: Review Published on: 20 November 2015
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