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Reviews

This list will be updated with all our new Reviews. Genome Medicine publishes Reviews that are open access and therefore free to read and share.

 

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  2. The rapid advancement of single-cell transcriptomics in neurology has allowed for profiling of post-mortem human brain tissue across multiple diseases. Over the past 3 years, several studies have examined tiss...

    Authors: Tain Luquez, Pallavi Gaur, Ivy M Kosater, Matti Lam, Dylan I Lee, Jason Mares, Fahad Paryani, Archana Yadav and Vilas Menon
    Citation: Genome Medicine 2022 14:136
    Content type: Review Published on:

  4. Recent rapid biotechnological breakthroughs have led to the identification of complex and unique molecular features that drive malignancies. Precision medicine has exploited next-generation sequencing and matc...

    Authors: Elena Fountzilas, Apostolia M. Tsimberidou, Henry Hiep Vo and Razelle Kurzrock
    Citation: Genome Medicine 2022 14:101
    Content type: Review Published on:

  5. Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights have been gained into virus biology and the host factors that modulate the human immune response against severe acute res...

    Authors: Caspar I. van der Made, Mihai G. Netea, Frank L. van der Veerdonk and Alexander Hoischen
    Citation: Genome Medicine 2022 14:96
    Content type: Review Published on:

  6. The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant contact with the brain borders, thus permitting insights into the brain to diagnose and monitor diseases. Recently, th...

    Authors: Michael Heming, Anna-Lena Börsch, Heinz Wiendl and Gerd Meyer zu Hörste
    Citation: Genome Medicine 2022 14:94
    Content type: Review Published on:

  7. The interaction between the metabolic activities of the intestinal microbiome and its host forms an important part of health. The basis of this interaction is in part mediated by the release of microbially-der...

    Authors: Timothy O. Cox, Patrick Lundgren, Kirti Nath and Christoph A. Thaiss
    Citation: Genome Medicine 2022 14:80
    Content type: Review Published on:

  8. Single-cell transcriptomics (scRNA-seq) has become essential for biomedical research over the past decade, particularly in developmental biology, cancer, immunology, and neuroscience. Most commercially availab...

    Authors: Cameron G. Williams, Hyun Jae Lee, Takahiro Asatsuma, Roser Vento-Tormo and Ashraful Haque
    Citation: Genome Medicine 2022 14:68
    Content type: Review Published on:

  10. Antimicrobial resistance (AMR) is a major global public health threat, which has been largely driven by the excessive use of antimicrobials. Control measures are urgently needed to slow the trajectory of AMR b...

    Authors: Claire Waddington, Megan E. Carey, Christine J. Boinett, Ellen Higginson, Balaji Veeraraghavan and Stephen Baker
    Citation: Genome Medicine 2022 14:15
    Content type: Review Published on:

  12. Deep learning is a subdiscipline of artificial intelligence that uses a machine learning technique called artificial neural networks to extract patterns and make predictions from large data sets. The increasin...

    Authors: Khoa A. Tran, Olga Kondrashova, Andrew Bradley, Elizabeth D. Williams, John V. Pearson and Nicola Waddell
    Citation: Genome Medicine 2021 13:152
    Content type: Review Published on:

  15. Knowledge of the molecular etiology of neurodegenerative brain diseases (NBD) has substantially increased over the past three decades. Early genetic studies of NBD families identified rare and highly penetrant...

    Authors: Federica Perrone, Rita Cacace, Julie van der Zee and Christine Van Broeckhoven
    Citation: Genome Medicine 2021 13:59
    Content type: Review Published on:

  18. Personalised dietary modulation of the gut microbiota may be key to disease management. Current investigations provide a broad understanding of the impact of diet on the composition and activity of the gut mic...

    Authors: Emily R. Leeming, Panayiotis Louca, Rachel Gibson, Cristina Menni, Tim D. Spector and Caroline I. Le Roy
    Citation: Genome Medicine 2021 13:10
    Content type: Review Published on:

  20. The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses that performs essential functions for immune development, pathogen colonization resistance, and food metabolism. Pertur...

    Authors: Drew J. Schwartz, Amy E. Langdon and Gautam Dantas
    Citation: Genome Medicine 2020 12:82
    Content type: Review Published on:

    The Correction to this article has been published in Genome Medicine 2021 13:26

  26. The number of druggable tumor-specific molecular aberrations has grown substantially in the past decade, with a significant survival benefit obtained from biomarker matching therapies in several cancer types. ...

    Authors: Eoghan R. Malone, Marc Oliva, Peter J. B. Sabatini, Tracy L. Stockley and Lillian L. Siu
    Citation: Genome Medicine 2020 12:8
    Content type: Review Published on:

  27. Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regul...

    Authors: Filipa Rijo-Ferreira and Joseph S. Takahashi
    Citation: Genome Medicine 2019 11:82
    Content type: Review Published on:

  29. Artificial intelligence (AI) is the development of computer systems that are able to perform tasks that normally require human intelligence. Advances in AI software and hardware, especially deep learning algor...

    Authors: Raquel Dias and Ali Torkamani
    Citation: Genome Medicine 2019 11:70
    Content type: Review Published on:

  32. Neoantigens are newly formed peptides created from somatic mutations that are capable of inducing tumor-specific T cell recognition. Recently, researchers and clinicians have leveraged next generation sequenci...

    Authors: Megan M. Richters, Huiming Xia, Katie M. Campbell, William E. Gillanders, Obi L. Griffith and Malachi Griffith
    Citation: Genome Medicine 2019 11:56
    Content type: Review Published on:

  33. Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium tuberculosis, the causative ...

    Authors: Keira A. Cohen, Abigail L. Manson, Christopher A. Desjardins, Thomas Abeel and Ashlee M. Earl
    Citation: Genome Medicine 2019 11:45
    Content type: Review Published on:

  35. In recent years, the number of studies investigating the impact of the gut microbiome in colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes (and microbial communities) ar...

    Authors: Jawara Allen and Cynthia L. Sears
    Citation: Genome Medicine 2019 11:11
    Content type: Review Published on:

  36. Immune checkpoint blockade (ICB) therapies, which potentiate the body’s natural immune response against tumor cells, have shown immense promise in the treatment of various cancers. Currently, tumor mutational ...

    Authors: Jake R. Conway, Eric Kofman, Shirley S. Mo, Haitham Elmarakeby and Eliezer Van Allen
    Citation: Genome Medicine 2018 10:93
    Content type: Review Published on:

  38. Neuroimaging genomics is a relatively new field focused on integrating genomic and imaging data in order to investigate the mechanisms underlying brain phenotypes and neuropsychiatric disorders. While early wo...

    Authors: Mary S. Mufford, Dan J. Stein, Shareefa Dalvie, Nynke A. Groenewold, Paul M. Thompson and Neda Jahanshad
    Citation: Genome Medicine 2017 9:102
    Content type: Review Published on:

  39. Next-generation sequencing (NGS) is now more accessible to clinicians and researchers. As a result, our understanding of the genetics of neurodevelopmental disorders (NDDs) has rapidly advanced over the past f...

    Authors: Amy B. Wilfert, Arvis Sulovari, Tychele N. Turner, Bradley P. Coe and Evan E. Eichler
    Citation: Genome Medicine 2017 9:101
    Content type: Review Published on:

  41. RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative analysis of messenger RNA molecules in a biological sample and is useful for studying cellular responses. RNA-seq has fueled mu...

    Authors: Ashraful Haque, Jessica Engel, Sarah A. Teichmann and Tapio Lönnberg
    Citation: Genome Medicine 2017 9:75
    Content type: Review Published on:

  43. The Human Genome Project and advances in DNA sequencing technologies have revolutionized the identification of genetic disorders through the use of clinical exome sequencing. However, in a considerable number ...

    Authors: Charles A. Steward, Alasdair P. J. Parker, Berge A. Minassian, Sanjay M. Sisodiya, Adam Frankish and Jennifer Harrow
    Citation: Genome Medicine 2017 9:49
    Content type: Review Published on:

  47. The rise of genomically targeted therapies and immunotherapy has revolutionized the practice of oncology in the last 10–15 years. At the same time, new technologies and the electronic health record (EHR) in pa...

    Authors: Jeremy L. Warner, Sandeep K. Jain and Mia A. Levy
    Citation: Genome Medicine 2016 8:113
    Content type: Review Published on:

  49. Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, ...

    Authors: Sebastian Kirchner, B. Joanne Power and Andrew P. Waters
    Citation: Genome Medicine 2016 8:92
    Content type: Review Published on: