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Reviews

This list will be updated with all our new Reviews. Genome Medicine publishes Reviews that are open access and therefore free to read and share.

 

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  1. Antimicrobial resistance (AMR) is a major global public health threat, which has been largely driven by the excessive use of antimicrobials. Control measures are urgently needed to slow the trajectory of AMR b...

    Authors: Claire Waddington, Megan E. Carey, Christine J. Boinett, Ellen Higginson, Balaji Veeraraghavan and Stephen Baker
    Citation: Genome Medicine 2022 14:15
  2. Deep learning is a subdiscipline of artificial intelligence that uses a machine learning technique called artificial neural networks to extract patterns and make predictions from large data sets. The increasin...

    Authors: Khoa A. Tran, Olga Kondrashova, Andrew Bradley, Elizabeth D. Williams, John V. Pearson and Nicola Waddell
    Citation: Genome Medicine 2021 13:152
  3. Knowledge of the molecular etiology of neurodegenerative brain diseases (NBD) has substantially increased over the past three decades. Early genetic studies of NBD families identified rare and highly penetrant...

    Authors: Federica Perrone, Rita Cacace, Julie van der Zee and Christine Van Broeckhoven
    Citation: Genome Medicine 2021 13:59
  4. Personalised dietary modulation of the gut microbiota may be key to disease management. Current investigations provide a broad understanding of the impact of diet on the composition and activity of the gut mic...

    Authors: Emily R. Leeming, Panayiotis Louca, Rachel Gibson, Cristina Menni, Tim D. Spector and Caroline I. Le Roy
    Citation: Genome Medicine 2021 13:10
  5. The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses that performs essential functions for immune development, pathogen colonization resistance, and food metabolism. Pertur...

    Authors: Drew J. Schwartz, Amy E. Langdon and Gautam Dantas
    Citation: Genome Medicine 2020 12:82

    The Correction to this article has been published in Genome Medicine 2021 13:26

  6. The number of druggable tumor-specific molecular aberrations has grown substantially in the past decade, with a significant survival benefit obtained from biomarker matching therapies in several cancer types. ...

    Authors: Eoghan R. Malone, Marc Oliva, Peter J. B. Sabatini, Tracy L. Stockley and Lillian L. Siu
    Citation: Genome Medicine 2020 12:8
  7. Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regul...

    Authors: Filipa Rijo-Ferreira and Joseph S. Takahashi
    Citation: Genome Medicine 2019 11:82
  8. Artificial intelligence (AI) is the development of computer systems that are able to perform tasks that normally require human intelligence. Advances in AI software and hardware, especially deep learning algor...

    Authors: Raquel Dias and Ali Torkamani
    Citation: Genome Medicine 2019 11:70
  9. Neoantigens are newly formed peptides created from somatic mutations that are capable of inducing tumor-specific T cell recognition. Recently, researchers and clinicians have leveraged next generation sequenci...

    Authors: Megan M. Richters, Huiming Xia, Katie M. Campbell, William E. Gillanders, Obi L. Griffith and Malachi Griffith
    Citation: Genome Medicine 2019 11:56
  10. Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium tuberculosis, the causative ...

    Authors: Keira A. Cohen, Abigail L. Manson, Christopher A. Desjardins, Thomas Abeel and Ashlee M. Earl
    Citation: Genome Medicine 2019 11:45
  11. In recent years, the number of studies investigating the impact of the gut microbiome in colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes (and microbial communities) ar...

    Authors: Jawara Allen and Cynthia L. Sears
    Citation: Genome Medicine 2019 11:11
  12. Immune checkpoint blockade (ICB) therapies, which potentiate the body’s natural immune response against tumor cells, have shown immense promise in the treatment of various cancers. Currently, tumor mutational ...

    Authors: Jake R. Conway, Eric Kofman, Shirley S. Mo, Haitham Elmarakeby and Eliezer Van Allen
    Citation: Genome Medicine 2018 10:93
  13. Neuroimaging genomics is a relatively new field focused on integrating genomic and imaging data in order to investigate the mechanisms underlying brain phenotypes and neuropsychiatric disorders. While early wo...

    Authors: Mary S. Mufford, Dan J. Stein, Shareefa Dalvie, Nynke A. Groenewold, Paul M. Thompson and Neda Jahanshad
    Citation: Genome Medicine 2017 9:102
  14. Next-generation sequencing (NGS) is now more accessible to clinicians and researchers. As a result, our understanding of the genetics of neurodevelopmental disorders (NDDs) has rapidly advanced over the past f...

    Authors: Amy B. Wilfert, Arvis Sulovari, Tychele N. Turner, Bradley P. Coe and Evan E. Eichler
    Citation: Genome Medicine 2017 9:101
  15. RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative analysis of messenger RNA molecules in a biological sample and is useful for studying cellular responses. RNA-seq has fueled mu...

    Authors: Ashraful Haque, Jessica Engel, Sarah A. Teichmann and Tapio Lönnberg
    Citation: Genome Medicine 2017 9:75
  16. The Human Genome Project and advances in DNA sequencing technologies have revolutionized the identification of genetic disorders through the use of clinical exome sequencing. However, in a considerable number ...

    Authors: Charles A. Steward, Alasdair P. J. Parker, Berge A. Minassian, Sanjay M. Sisodiya, Adam Frankish and Jennifer Harrow
    Citation: Genome Medicine 2017 9:49
  17. The rise of genomically targeted therapies and immunotherapy has revolutionized the practice of oncology in the last 10–15 years. At the same time, new technologies and the electronic health record (EHR) in pa...

    Authors: Jeremy L. Warner, Sandeep K. Jain and Mia A. Levy
    Citation: Genome Medicine 2016 8:113
  18. Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, ...

    Authors: Sebastian Kirchner, B. Joanne Power and Andrew P. Waters
    Citation: Genome Medicine 2016 8:92
  19. Humans are virtually identical in their genetic makeup, yet the small differences in our DNA give rise to tremendous phenotypic diversity across the human population. By contrast, the metagenome of the human m...

    Authors: Jason Lloyd-Price, Galeb Abu-Ali and Curtis Huttenhower
    Citation: Genome Medicine 2016 8:51
  20. The human gut harbors more than 100 trillion microbial cells, which have an essential role in human metabolic regulation via their symbiotic interactions with the host. Altered gut microbial ecosystems have be...

    Authors: Claire L. Boulangé, Ana Luisa Neves, Julien Chilloux, Jeremy K. Nicholson and Marc-Emmanuel Dumas
    Citation: Genome Medicine 2016 8:42
  21. Infections encountered in the cancer setting may arise from intensive cancer treatments or may result from the cancer itself, leading to risk of infections through immune compromise, disruption of anatomic bar...

    Authors: Ying Taur and Eric G. Pamer
    Citation: Genome Medicine 2016 8:40