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This list will be updated with all our new Reviews. Genome Biology publishes reviews that are open access and therefore free to read and share.
Review
Plants frequently have to weather both biotic and abiotic stressors, and have evolved sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications, nucleosome positioning, and DNA ...
Genome Biology 2017 18:124
Published on: 27 June 2017
Review
Studies on genetic–epigenetic interactions, including the mapping of methylation quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation (hap-ASM), have become a major focus in ...
Genome Biology 2017 18:120
Published on: 19 June 2017
Review
Chromatin is not a uniform macromolecular entity; it contains different domains characterized by complex signatures of DNA and histone modifications. Such domains are organized both at a linear scale along the...
Genome Biology 2017 18:96
Published on: 23 May 2017
Review
Plant development is predominantly postembryonic and tuned in to respond to environmental cues. All living plant cells can be triggered to de-differentiate, assume different cell identities, or form a new orga...
Genome Biology 2017 18:88
Published on: 10 May 2017
Review
High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which ...
Genome Biology 2017 18:83
Published on: 5 May 2017
Review
Despite thousands of genetic loci identified to date, a large proportion of genetic variation predisposing to complex disease and traits remains unaccounted for. Advances in sequencing technology enable focuse...
Genome Biology 2017 18:77
Published on: 27 April 2017
Review
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases. Recent advanc...
Genome Biology 2017 18:76
Published on: 27 April 2017
Review
High-throughput assays for measuring the three-dimensional (3D) configuration of DNA have provided unprecedented insights into the relationship between DNA 3D configuration and function. Data interpretation fr...
Genome Biology 2017 18:26
Published on: 3 February 2017
Review
Despite major progress in dissecting the molecular pathways that control DNA methylation patterns in plants, little is known about the mechanisms that shape plant methylomes over evolutionary time. Drawing on ...
Genome Biology 2016 17:264
Published on: 20 December 2016
The Erratum to this article has been published in Genome Biology 2017 18:41
Review
Aside from inheriting half of the genome of each of our parents, we are born with a small number of novel mutations that occurred during gametogenesis and postzygotically. Recent genome and exome sequencing st...
Genome Biology 2016 17:241
Published on: 28 November 2016
Review
The wealth of available genetic information is allowing the reconstruction of human demographic and adaptive history. Demography and purifying selection affect the purge of rare, deleterious mutations from the...
Genome Biology 2016 17:225
Published on: 7 November 2016
Review
Many factors affect the microbiomes of humans, mice, and other mammals, but substantial challenges remain in determining which of these factors are of practical importance. Considering the relative effect size...
Genome Biology 2016 17:217
Published on: 19 October 2016
Review
Chromosome conformation capture (3C)-based techniques have revolutionized the field of nuclear organization, partly replacing DNA FISH as the method of choice for studying three-dimensional chromosome architec...
Genome Biology 2016 17:215
Published on: 19 October 2016
Review
We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness...
Genome Biology 2016 17:183
Published on: 31 August 2016
Review
Chloroplasts play a crucial role in sustaining life on earth. The availability of over 800 sequenced chloroplast genomes from a variety of land plants has enhanced our understanding of chloroplast biology, int...
Genome Biology 2016 17:134
Published on: 23 June 2016
Review
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish nove...
Genome Biology 2016 17:100
Published on: 9 May 2016
Review
Almost 20 % of all infectious human diseases are vector borne and, together, are responsible for over one million deaths per annum. Over the past decade, the decreasing costs of massively parallel sequencing t...
Genome Biology 2016 17:95
Published on: 6 May 2016
Review
Cell-to-cell variation and heterogeneity are fundamental and intrinsic characteristics of stem cell populations, but these differences are masked when bulk cells are used for omic analysis. Single-cell sequenc...
Genome Biology 2016 17:71
Published on: 15 April 2016
Review
Single-cell RNA-sequencing (scRNA-seq) has emerged as a revolutionary tool that allows us to address scientific questions that eluded examination just a few years ago. With the advantages of scRNA-seq come com...
Genome Biology 2016 17:63
Published on: 7 April 2016
Review
Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensi...
Genome Biology 2016 17:54
Published on: 7 April 2016
Review
The incidence and geographic range of dengue have increased dramatically in recent decades. Climate change, rapid urbanization and increased global travel have facilitated the spread of both efficient mosquito...
Genome Biology 2016 17:38
Published on: 2 March 2016
Review
We have witnessed an explosion in our understanding of the evolution and structure of plant genomes in recent years. Here, we highlight three important emergent realizations: (1) that the evolutionary history of
Genome Biology 2016 17:37
Published on: 1 March 2016
Review
RNA-sequencing (RNA-seq) has a wide variety of applications, but no single analysis pipeline can be used in all cases. We review all of the major steps in RNA-seq data analysis, including experimental design, ...
Genome Biology 2016 17:13
Published on: 26 January 2016
The Erratum to this article has been published in Genome Biology 2016 17:181
Review
Ancient DNA research is revealing a human history far more complex than that inferred from parsimonious models based on modern DNA. Here, we review some of the key events in the peopling of the world in the li...
Genome Biology 2016 17:1
Published on: 11 January 2016
