Skip to content

Advertisement

You're viewing the new version of our site. Please leave us feedback.

Learn more

Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR

Previous Page Page 1 of 2 Next Page
  1. Content type: Review

    CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested t...

    Authors: Yu Zhang, Wei Liang, Peng Zhang, Jingyan Chen, Hui Qian, Xu Zhang and Wenrong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:152

    Published on:

  2. Content type: Review

    The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically t...

    Authors: Nicola Silvestris, Gennaro Ciliberto, Paolo De Paoli, Giovanni Apolone, Maria Luisa Lavitrano, Marco A. Pierotti and Giorgio Stanta

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:128

    Published on:

  3. Content type: Review

    Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the...

    Authors: Andrew S. Gdowski, Amalendu Ranjan and Jamboor K. Vishwanatha

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:108

    Published on:

  4. Content type: Review

    Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remai...

    Authors: Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary and Nor Hayati Othman

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:98

    Published on:

  5. Content type: Review

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex s...

    Authors: A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso and G. Fibbi

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:80

    Published on:

  6. Content type: Review

    The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene i...

    Authors: Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr. and Aldo Venuti

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:71

    Published on:

  7. Content type: Review

    Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS). MM is a biologically complex ...

    Authors: Anna Shvartsur, Kevin B. Givechian, Hermes Garban and Benjamin Bonavida

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:62

    Published on:

  8. Content type: Review

    Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is involved in several molecul...

    Authors: Valeria Catena and Maurizio Fanciulli

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:12

    Published on:

  9. Content type: Review

    Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the ‘right’ tre...

    Authors: Luca Pompili, Manuela Porru, Carla Caruso, Annamaria Biroccio and Carlo Leonetti

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:189

    Published on:

  10. Content type: Review

    The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair...

    Authors: Zhen Mei, Xian Zhang, Jiarong Yi, Junjie Huang, Jian He and Yongguang Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:182

    Published on:

  11. Content type: Review

    DNA damage response (DDR) defects imply genomic instability and favor tumor progression but make the cells vulnerable to the pharmacological inhibition of the DNA repairing enzymes. Targeting cellular proteins...

    Authors: Aniello Cerrato, Francesco Morra and Angela Celetti

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:179

    Published on:

  12. Content type: Review

    Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1) is a potent oncogene overe...

    Authors: Mahmoud Alhosin, Ziad Omran, Mazin A. Zamzami, Abdulrahman L. Al-Malki, Hani Choudhry, Marc Mousli and Christian Bronner

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:174

    Published on:

  13. Content type: Review

    Among several types of tumor, lung cancer is considered one of the most fatal and still the main cause of cancer-related deaths. Although chemotherapeutic agents can improve survival and quality of life compar...

    Authors: Mohanad Aldarouish and Cailian Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:157

    Published on:

  14. Content type: Review

    Exosomes are nanoscale extracellular membrane vesicles that are created by the fusion of an intracellular multivesicular body with the cell membrane. They are widely distributed in serum, urine, saliva and oth...

    Authors: Wenting Xu, Zhen Yang and Nonghua Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:156

    Published on:

  15. Content type: Review

    Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of ce...

    Authors: Roberta Visconti, Rosa Della Monica and Domenico Grieco

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:153

    Published on:

  16. Content type: Review

    The advent of targeted therapeutics in human cancer has begun to find novel druggable targets and, in this context, the endothelin-1 receptor (ET-1R), namely ETA receptor (ETAR) and ETB receptor, among the GPCR f...

    Authors: Laura Rosanò and Anna Bagnato

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:121

    Published on:

  17. Content type: Review

    Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer...

    Authors: Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino and Alessandra Micera

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:116

    Published on:

  18. Content type: Review

    The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outc...

    Authors: Alessandra Fabi, Paola Malaguti, Sabrina Vari and Francesco Cognetti

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:104

    Published on:

  19. Content type: Review

    The role of immune response is emerging as a key factor in the complex multistep process of cancer. Tumor microenvironment contains different types of immune cells, which contribute to regulate the fine balanc...

    Authors: Laura Paladini, Linda Fabris, Giulia Bottai, Carlotta Raschioni, George A. Calin and Libero Santarpia

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:103

    Published on:

  20. Content type: Review

    The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability, epithelial-mesenchymal tran...

    Authors: Samantha Kaufhold, Hermes Garbán and Benjamin Bonavida

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:84

    Published on:

  21. Content type: Review

    A widespread decrease of mature microRNAs is often observed in human malignancies giving them potential to act as tumor suppressors. Thus, microRNAs may be potential targets for cancer therapy. The global miRN...

    Authors: Aymone Gurtner, Emmanuela Falcone, Francesca Garibaldi and Giulia Piaggio

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:45

    Published on:

  22. Content type: Review

    Acting as inflammatory mediators, tumor oncogenes or suppressors, microRNAs are involved in cell survival, death, epithelial–mesenchymal transition and metastasis, etc. Investigating the communication between ...

    Authors: Yudan Chi and Dongming Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:43

    Published on:

  23. Content type: Review

    Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies ...

    Authors: Yuanliang Yan, Zhijie Xu, Shuang Dai, Long Qian, Lunquan Sun and Zhicheng Gong

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:23

    Published on:

  24. Content type: Review

    Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family. It is widely expressed in human fetal and adult tissues but its...

    Authors: Louiza Belkacemi and Shaun Xiaoliu Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:4

    Published on:

  25. Content type: Review

    Despite the global decline in the incidence and mortality of gastric cancer, it remains one of the most common malignant tumors of the digestive system. Although surgical resection is the preferred treatment f...

    Authors: Wenting Xu, Zhen Yang and Nonghua Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:1

    Published on:

  26. Content type: Review

    Increased understanding of the genetic aetiology of advanced non-small-cell lung cancer (aNSCLC) has facilitated personalised therapies that target specific molecular aberrations associated with the disease. B...

    Authors: James Sherwood, Simon Dearden, Marianne Ratcliffe and Jill Walker

    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:92

    Published on:

  27. Content type: Review

    The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancer...

    Authors: Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch and Ziad Omran

    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:93

    Published on:

  28. Content type: Review

    Zebrafish represent a vertebrate model organism that has been widely, and increasingly, employed over the last decade in the study of developmental processes, wound healing, microbe-host interactions, and drug...

    Authors: Shuai Zhao, Jian Huang and Jun Ye

    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:80

    Published on:

  29. Content type: Review

    A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great attention in cancer research since they play a central role in regulation of gene-expression and miRNA aberrant expressio...

    Authors: Germana Falcone, Armando Felsani and Igea D’Agnano

    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:32

    Published on:

  30. Content type: Review

    Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. H...

    Authors: Mingxu Guan, Gaetano Romano, Roberta Coroniti and Earl E Henderson

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:91

    Published on:

  31. Content type: Review

    The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and R...

    Authors: Ting-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran and Chun-Meng Shi

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:64

    Published on:

  32. Content type: Review

    Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors, which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell differentiation and surviva...

    Authors: Samantha Kaufhold and Benjamin Bonavida

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:62

    Published on:

  33. Content type: Review

    MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are involved in diverse biological processe...

    Authors: Qin Qin, Wei Furong and Li Baosheng

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:50

    Published on:

  34. Content type: Review

    Liver metastases occur in 46-93% of patients with neuroendocrine neoplasms (NENs). Presence and extension of liver metastases are considered important prognostic factors, as they may significantly impair the p...

    Authors: Michela Del Prete, Francesco Fiore, Roberta Modica, Vincenzo Marotta, Francesca Marciello, Valeria Ramundo, Antonella Di Sarno, Annachiara Carratù, Chiara de Luca di Roseto, Salvatore Tafuto, Fabiana Tatangelo, Robero Baldelli, Annamaria Colao and Antongiulio Faggiano

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:43

    Published on:

  35. Content type: Review

    Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of ant...

    Authors: Ruijin Shao, Xin Li, Yi Feng, Jin-Fang Lin and Håkan Billig

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:41

    Published on:

  36. Content type: Review

    Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature...

    Authors: Evandro Luís Niero, Bianca Rocha-Sales, Camila Lauand, Beatriz Araujo Cortez, Marcelo Medina de Souza, Paula Rezende-Teixeira, Marcel Shiniti Urabayashi, Adam Arai Martens, Jorge Henrique Neves and Gláucia Maria Machado-Santelli

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:37

    Published on:

  37. Content type: Review

    Development of HPV-associated cancers not only depends on efficient negative regulation of cell cycle control that supports the accumulation of genetic damage, but also relies on immune evasion that enable the...

    Authors: Patrizia Vici, Luciano Mariani, Laura Pizzuti, Domenico Sergi, Luigi Di Lauro, Enrico Vizza, Federica Tomao, Silverio Tomao, Claudia Cavallotti, Francesca Paolini and Aldo Venuti

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:29

    Published on:

  38. Content type: Review

    Over the last decades, billions have been spent and huge efforts have been taken in basic and clinical cancer research [CA Cancer J Clin 63: 11-30]. About a decade ago, the arms race between drugs and cancer cell...

    Authors: Niels Eckstein, Lea Röper, Bodo Haas, Henrike Potthast, Ulrike Hermes, Christoph Unkrig, Frauke Naumann-Winter and Harald Enzmann

    Citation: Journal of Experimental & Clinical Cancer Research 2014 33:15

    Published on:

  39. Content type: Review

    Numerous studies have yielded inconclusive results regarding the relationship between anti-apoptotic protein Bcl-2 expression and the sensitivity to chemotherapy in the patients with breast cancer. The purpose...

    Authors: Dong Yang, Min-Bin Chen, Li-Qiang Wang, Lan Yang, Chao-Ying Liu and Pei-Hua Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:105

    Published on:

  40. Content type: Review

    Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modificati...

    Authors: Xiaolan Liu, Xiaoyan Chen, Xinfang Yu, Yongguang Tao, Ann M Bode, Zigang Dong and Ya Cao

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:96

    Published on:

  41. Content type: Review

    Fluoropyrimidines, oxaliplatin, irinotecan and biologic therapies (Bevacizumab, Panitumumab, and Cetuximab) represent the backbone of metastatic colorectal cancer (CRC) treatment. The improvement in survival f...

    Authors: Giuseppe Tonini, Marco Imperatori, Bruno Vincenzi, Anna Maria Frezza and Daniele Santini

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:92

    Published on:

  42. Content type: Review

    The effectiveness of different breast cancer follow-up procedures to decrease breast cancer mortality are still an object of debate, even if intensive follow-up by imaging modalities is not recommended by inte...

    Authors: Isabella Sperduti, Patrizia Vici, Nicola Tinari, Teresa Gamucci, Michele De Tursi, Giada Cortese, Antonino Grassadonia, Stefano Iacobelli and Clara Natoli

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:89

    Published on:

  43. Content type: Review

    In 2013 there will be an estimated 22,240 new diagnoses and 14,030 deaths from ovarian cancer in the United States. Despite the improved surgical approach and the novel active drugs that are available today in...

    Authors: Federica Tomao, Anselmo Papa, Luigi Rossi, Martina Strudel, Patrizia Vici, Giuseppe Lo Russo and Silverio Tomao

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:48

    Published on:

  44. Content type: Review

    The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results wer...

    Authors: Yanlong Yang, Yuanliang Xie and Lei Xian

    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:15

    Published on:

  45. Content type: Review

    Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early int...

    Authors: Xiao-Tong Wang, Wei-Yuan Wei, Fan-Biao Kong, Chao Lian, Wen Luo, Qiang Xiao and Yu-Bo Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:98

    Published on:

  46. Content type: Review

    Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therap...

    Authors: Gabriella D’Orazi, Cinzia Rinaldo and Silvia Soddu

    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:63

    Published on:

Previous Page Page 1 of 2 Next Page

Advertisement