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Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR

Page 1 of 5
  1. Content type: Review

    Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but al...

    Authors: Shi-qiong Huang, Bao Sun, Zong-ping Xiong, Yan Shu, Hong-hao Zhou, Wei Zhang, Jing Xiong and Qing Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:101

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  2. Content type: Review

    Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably...

    Authors: Le Tang, Fang Wei, Yingfen Wu, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Hao Deng, Ke Cao, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:87

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  3. Content type: Review

    In the advent of Immune Checkpoint inhibitors (ICI) and of CAR-T adoptive T-cells, the new frontier in Oncology is Cancer Immunotherapy because of its ability to provide long term clinical benefit in metastati...

    Authors: Luigi Aurisicchio, Matteo Pallocca, Gennaro Ciliberto and Fabio Palombo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:86

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  4. Content type: Review

    The epidermal growth factor receptor (EGFR) plays important roles in cell survival, growth, differentiation, and tumorigenesis. Dysregulation of the EGFR is a common mechanism in cancer progression especially ...

    Authors: Meng-Shih Weng, Jer-Hwa Chang, Wen-Yueh Hung, Yi-Chieh Yang and Ming-Hsien Chien

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:61

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  5. Content type: Review

    With cancer stem cells (CSCs) became the research hotspot, emerging studies attempt to reveal the functions of these special subsets in tumorigenesis. Although various approaches have been used in CSCs researc...

    Authors: Y. T. Luo, J. Cheng, X. Feng, S. J. He, Y. W. Wang and Q. Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:38

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  6. Content type: Review

    Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased understanding of disease pathobiology and genomics has led to clinical investigation of novel targeted therapies and ratio...

    Authors: Silvia Boffo, Angela Damato, Luigi Alfano and Antonio Giordano

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:36

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  7. Content type: Review

    Since Salinomycin (Sal) emerged its ability to target breast cancer stem cells in 2009, numerous experiments have been carried out to test Sal’s anticancer effects. What deserve to be mentioned is that Sal can...

    Authors: Jiang Jiang, Hailong Li, Eskandar Qaed, Jing Zhang, Yushu Song, Rong Wu, Xinmiao Bu, Qinyan Wang and Zeyao Tang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:26

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  8. Content type: Review

    Antibody-Drug Conjugates (ADCs) are a class of cancer therapeutics that combines antigen specificity and potent cytotoxicity in a single molecule as they are comprised of an engineered antibody linked chemical...

    Authors: Cécile Chalouni and Sophia Doll

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:20

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  9. Content type: Review

    Cancer remains as one of the leading cause of death worldwide. The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Although most studies have ...

    Authors: Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos and Kulmira Nurgali

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:5

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  10. Content type: Review

    Osteosarcoma (OS) is the most common primary malignant tumor of bone, which preferentially develops lung metastasis. Although standard chemotherapy has significantly improved long-term survival over the past f...

    Authors: Angela De Luca, Lavinia Raimondi, Francesca Salamanna, Valeria Carina, Viviana Costa, Daniele Bellavia, Riccardo Alessandro, Milena Fini and Gianluca Giavaresi

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:2

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  11. Content type: Review

    Telomeres are specialized nucleoprotein structures responsible for protecting chromosome ends in order to prevent the loss of genomic information. Telomere maintenance is required for achieving immortality by ...

    Authors: Luca Pompili, Carlo Leonetti, Annamaria Biroccio and Erica Salvati

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:189

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  12. Content type: Review

    Mantle cell lymphoma (MCL) is an aggressive disease, with poor prognosis and a limited survival. However, some patients with indolent MCL can survive beyond 7~10 years. These patients remain largely asymptomat...

    Authors: Haige Ye, Aakash Desai, Dongfeng Zeng, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed and Michael L. Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:185

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  13. Content type: Review

    Glioblastoma Multiforme is the deadliest type of brain tumor and is characterized by very poor prognosis with a limited overall survival. Current optimal therapeutic approach has essentially remained unchanged...

    Authors: Claudia Abbruzzese, Silvia Matteoni, Michele Signore, Luca Cardone, Kavindra Nath, Jerry D. Glickson and Marco G. Paggi

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:169

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  14. Content type: Review

    CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested t...

    Authors: Yu Zhang, Wei Liang, Peng Zhang, Jingyan Chen, Hui Qian, Xu Zhang and Wenrong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:152

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  15. Content type: Review

    The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically t...

    Authors: Nicola Silvestris, Gennaro Ciliberto, Paolo De Paoli, Giovanni Apolone, Maria Luisa Lavitrano, Marco A. Pierotti and Giorgio Stanta

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:128

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  16. Content type: Review

    Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the...

    Authors: Andrew S. Gdowski, Amalendu Ranjan and Jamboor K. Vishwanatha

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:108

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  17. Content type: Review

    Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remai...

    Authors: Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary and Nor Hayati Othman

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:98

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  18. Content type: Review

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex s...

    Authors: A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso and G. Fibbi

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:80

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  19. Content type: Review

    The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene i...

    Authors: Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr. and Aldo Venuti

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:71

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  20. Content type: Review

    Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS). MM is a biologically complex ...

    Authors: Anna Shvartsur, Kevin B. Givechian, Hermes Garban and Benjamin Bonavida

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:62

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  21. Content type: Review

    Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is involved in several molecul...

    Authors: Valeria Catena and Maurizio Fanciulli

    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:12

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  22. Content type: Review

    The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair...

    Authors: Zhen Mei, Xian Zhang, Jiarong Yi, Junjie Huang, Jian He and Yongguang Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:182

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