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Reviews from Journal of Experimental & Clinical Cancer Research

Below is a summary of all reviews published in JECCR

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  1. Review

    Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

    Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and...

    Stephen Riffle and Rashmi S. Hegde

    Journal of Experimental & Clinical Cancer Research 2017 36:102

    Published on: 3 August 2017

  2. Review

    Curcumin: the spicy modulator of breast carcinogenesis

    Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remai...

    Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary and Nor Hayati Othman

    Journal of Experimental & Clinical Cancer Research 2017 36:98

    Published on: 19 July 2017

  3. Review

    Type II CRISPR/Cas9 approach in the oncological therapy

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex s...

    A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso and G. Fibbi

    Journal of Experimental & Clinical Cancer Research 2017 36:80

    Published on: 15 June 2017

  4. Review

    hrHPV E5 oncoprotein: immune evasion and related immunotherapies

    The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene i...

    Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr. and Aldo Venuti

    Journal of Experimental & Clinical Cancer Research 2017 36:71

    Published on: 25 May 2017

  5. Review

    Deptor: not only a mTOR inhibitor

    Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is involved in several molecul...

    Valeria Catena and Maurizio Fanciulli

    Journal of Experimental & Clinical Cancer Research 2017 36:12

    Published on: 13 January 2017

  6. Review

    Patient-derived xenografts: a relevant preclinical model for drug development

    Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the ‘right’ tre...

    Luca Pompili, Manuela Porru, Carla Caruso, Annamaria Biroccio and Carlo Leonetti

    Journal of Experimental & Clinical Cancer Research 2016 35:189

    Published on: 5 December 2016

  7. Review

    Sirtuins in metabolism, DNA repair and cancer

    The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair...

    Zhen Mei, Xian Zhang, Jiarong Yi, Junjie Huang, Jian He and Yongguang Tao

    Journal of Experimental & Clinical Cancer Research 2016 35:182

    Published on: 5 December 2016

  8. Review

    Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic

    DNA damage response (DDR) defects imply genomic instability and favor tumor progression but make the cells vulnerable to the pharmacological inhibition of the DNA repairing enzymes. Targeting cellular proteins...

    Aniello Cerrato, Francesco Morra and Angela Celetti

    Journal of Experimental & Clinical Cancer Research 2016 35:179

    Published on: 24 November 2016

  9. Review

    Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

    Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1) is a potent oncogene overe...

    Mahmoud Alhosin, Ziad Omran, Mazin A. Zamzami, Abdulrahman L. Al-Malki, Hani Choudhry, Marc Mousli and Christian Bronner

    Journal of Experimental & Clinical Cancer Research 2016 35:174

    Published on: 14 November 2016

  10. Review

    Trends and advances in tumor immunology and lung cancer immunotherapy

    Among several types of tumor, lung cancer is considered one of the most fatal and still the main cause of cancer-related deaths. Although chemotherapeutic agents can improve survival and quality of life compar...

    Mohanad Aldarouish and Cailian Wang

    Journal of Experimental & Clinical Cancer Research 2016 35:157

    Published on: 29 September 2016

  11. Review

    Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword

    Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of ce...

    Roberta Visconti, Rosa Della Monica and Domenico Grieco

    Journal of Experimental & Clinical Cancer Research 2016 35:153

    Published on: 27 September 2016

  12. Review

    β-arrestin1 at the cross-road of endothelin-1 signaling in cancer

    The advent of targeted therapeutics in human cancer has begun to find novel druggable targets and, in this context, the endothelin-1 receptor (ET-1R), namely ETA receptor (ETAR) and ETB receptor, among the GPCR f...

    Laura Rosanò and Anna Bagnato

    Journal of Experimental & Clinical Cancer Research 2016 35:121

    Published on: 29 July 2016

  13. Review

    First-line therapy in HER2 positive metastatic breast cancer: is the mosaic fully completed or are we missing additional pieces?

    The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outc...

    Alessandra Fabi, Paola Malaguti, Sabrina Vari and Francesco Cognetti

    Journal of Experimental & Clinical Cancer Research 2016 35:104

    Published on: 30 June 2016

  14. Review

    Targeting microRNAs as key modulators of tumor immune response

    The role of immune response is emerging as a key factor in the complex multistep process of cancer. Tumor microenvironment contains different types of immune cells, which contribute to regulate the fine balanc...

    Laura Paladini, Linda Fabris, Giulia Bottai, Carlotta Raschioni, George A. Calin and Libero Santarpia

    Journal of Experimental & Clinical Cancer Research 2016 35:103

    Published on: 27 June 2016

  15. Review

    MicroRNAs in colorectal carcinoma - from pathogenesis to therapy

    Acting as inflammatory mediators, tumor oncogenes or suppressors, microRNAs are involved in cell survival, death, epithelial–mesenchymal transition and metastasis, etc. Investigating the communication between ...

    Yudan Chi and Dongming Zhou

    Journal of Experimental & Clinical Cancer Research 2016 35:43

    Published on: 10 March 2016

  16. Review

    Targeting autophagy to sensitive glioma to temozolomide treatment

    Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies ...

    Yuanliang Yan, Zhijie Xu, Shuang Dai, Long Qian, Lunquan Sun and Zhicheng Gong

    Journal of Experimental & Clinical Cancer Research 2016 35:23

    Published on: 2 February 2016

  17. Review

    Molecular targeted therapy for the treatment of gastric cancer

    Despite the global decline in the incidence and mortality of gastric cancer, it remains one of the most common malignant tumors of the digestive system. Although surgical resection is the preferred treatment f...

    Wenting Xu, Zhen Yang and Nonghua Lu

    Journal of Experimental & Clinical Cancer Research 2016 35:1

    Published on: 4 January 2016

  18. Review

    Mutation status concordance between primary lesions and metastatic sites of advanced non-small-cell lung cancer and the impact of mutation testing methodologies: a literature review

    Increased understanding of the genetic aetiology of advanced non-small-cell lung cancer (aNSCLC) has facilitated personalised therapies that target specific molecular aberrations associated with the disease. B...

    James Sherwood, Simon Dearden, Marianne Ratcliffe and Jill Walker

    Journal of Experimental & Clinical Cancer Research 2015 34:92

    Published on: 4 September 2015

  19. Review

    Proton pump inhibitors for the treatment of cancer in companion animals

    The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancer...

    Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch and Ziad Omran

    Journal of Experimental & Clinical Cancer Research 2015 34:93

    Published on: 4 September 2015

  20. Review

    A fresh look at zebrafish from the perspective of cancer research

    Zebrafish represent a vertebrate model organism that has been widely, and increasingly, employed over the last decade in the study of developmental processes, wound healing, microbe-host interactions, and drug...

    Shuai Zhao, Jian Huang and Jun Ye

    Journal of Experimental & Clinical Cancer Research 2015 34:80

    Published on: 12 August 2015

  21. Review

    Signaling by exosomal microRNAs in cancer

    A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great attention in cancer research since they play a central role in regulation of gene-expression and miRNA aberrant expressio...

    Germana Falcone, Armando Felsani and Igea D’Agnano

    Journal of Experimental & Clinical Cancer Research 2015 34:32

    Published on: 2 April 2015

  22. Review

    Dual effect of oxidative stress on leukemia cancer induction and treatment

    Oxidative stress (OS) has been characterized by an imbalance between the production of reactive oxygen species (ROS) and a biological system’s ability to repair oxidative damage or to neutralize the reactive i...

    Udensi K Udensi and Paul B Tchounwou

    Journal of Experimental & Clinical Cancer Research 2014 33:106

    Published on: 18 December 2014

  23. Review

    Progress in oncolytic virotherapy for the treatment of thyroid malignant neoplasm

    Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. H...

    Mingxu Guan, Gaetano Romano, Roberta Coroniti and Earl E Henderson

    Journal of Experimental & Clinical Cancer Research 2014 33:91

    Published on: 1 November 2014

  24. Review

    P68 RNA helicase as a molecular target for cancer therapy

    The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and R...

    Ting-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran and Chun-Meng Shi

    Journal of Experimental & Clinical Cancer Research 2014 33:64

    Published on: 24 August 2014

  25. Review

    Multiple functions of hypoxia-regulated miR-210 in cancer

    MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are involved in diverse biological processe...

    Qin Qin, Wei Furong and Li Baosheng

    Journal of Experimental & Clinical Cancer Research 2014 33:50

    Published on: 9 June 2014

  26. Review

    Hepatic arterial embolization in patients with neuroendocrine tumors

    Liver metastases occur in 46-93% of patients with neuroendocrine neoplasms (NENs). Presence and extension of liver metastases are considered important prognostic factors, as they may significantly impair the p...

    Michela Del Prete, Francesco Fiore, Roberta Modica, Vincenzo Marotta, Francesca Marciello, Valeria Ramundo, Antonella Di Sarno, Annachiara Carratù, Chiara de Luca di Roseto, Salvatore Tafuto, Fabiana Tatangelo, Robero Baldelli, Annamaria Colao and Antongiulio Faggiano

    Journal of Experimental & Clinical Cancer Research 2014 33:43

    Published on: 19 May 2014

  27. Review

    Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma

    Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of ant...

    Ruijin Shao, Xin Li, Yi Feng, Jin-Fang Lin and Håkan Billig

    Journal of Experimental & Clinical Cancer Research 2014 33:41

    Published on: 11 May 2014

  28. Review

    The multiple facets of drug resistance: one history, different approaches

    Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly display resistance to chemotherapy, and this is the major obstacle to a better prognosis of patients. Frequently, literature...

    Evandro Luís Niero, Bianca Rocha-Sales, Camila Lauand, Beatriz Araujo Cortez, Marcelo Medina de Souza, Paula Rezende-Teixeira, Marcel Shiniti Urabayashi, Adam Arai Martens, Jorge Henrique Neves and Gláucia Maria Machado-Santelli

    Journal of Experimental & Clinical Cancer Research 2014 33:37

    Published on: 28 April 2014

  29. Review

    Immunologic treatments for precancerous lesions and uterine cervical cancer

    Development of HPV-associated cancers not only depends on efficient negative regulation of cell cycle control that supports the accumulation of genetic damage, but also relies on immune evasion that enable the...

    Patrizia Vici, Luciano Mariani, Laura Pizzuti, Domenico Sergi, Luigi Di Lauro, Enrico Vizza, Federica Tomao, Silverio Tomao, Claudia Cavallotti, Francesca Paolini and Aldo Venuti

    Journal of Experimental & Clinical Cancer Research 2014 33:29

    Published on: 26 March 2014

  30. Review

    Clinical pharmacology of tyrosine kinase inhibitors becoming generic drugs: the regulatory perspective

    Over the last decades, billions have been spent and huge efforts have been taken in basic and clinical cancer research [CA Cancer J Clin 63: 11-30]. About a decade ago, the arms race between drugs and cancer cell...

    Niels Eckstein, Lea Röper, Bodo Haas, Henrike Potthast, Ulrike Hermes, Christoph Unkrig, Frauke Naumann-Winter and Harald Enzmann

    Journal of Experimental & Clinical Cancer Research 2014 33:15

    Published on: 7 February 2014

  31. Review

    Bcl-2 expression predicts sensitivity to chemotherapy in breast cancer: a systematic review and meta-analysis

    Numerous studies have yielded inconclusive results regarding the relationship between anti-apoptotic protein Bcl-2 expression and the sensitivity to chemotherapy in the patients with breast cancer. The purpose...

    Dong Yang, Min-Bin Chen, Li-Qiang Wang, Lan Yang, Chao-Ying Liu and Pei-Hua Lu

    Journal of Experimental & Clinical Cancer Research 2013 32:105

    Published on: 27 December 2013

  32. Review

    Regulation of microRNAs by epigenetics and their interplay involved in cancer

    Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modificati...

    Xiaolan Liu, Xiaoyan Chen, Xinfang Yu, Yongguang Tao, Ann M Bode, Zigang Dong and Ya Cao

    Journal of Experimental & Clinical Cancer Research 2013 32:96

    Published on: 22 November 2013

  33. Review

    Rechallenge therapy and treatment holiday: different strategies in management of metastatic colorectal cancer

    Fluoropyrimidines, oxaliplatin, irinotecan and biologic therapies (Bevacizumab, Panitumumab, and Cetuximab) represent the backbone of metastatic colorectal cancer (CRC) treatment. The improvement in survival f...

    Giuseppe Tonini, Marco Imperatori, Bruno Vincenzi, Anna Maria Frezza and Daniele Santini

    Journal of Experimental & Clinical Cancer Research 2013 32:92

    Published on: 18 November 2013

  34. Review

    Breast cancer follow-up strategies in randomized phase III adjuvant clinical trials: a systematic review

    The effectiveness of different breast cancer follow-up procedures to decrease breast cancer mortality are still an object of debate, even if intensive follow-up by imaging modalities is not recommended by inte...

    Isabella Sperduti, Patrizia Vici, Nicola Tinari, Teresa Gamucci, Michele De Tursi, Giada Cortese, Antonino Grassadonia, Stefano Iacobelli and Clara Natoli

    Journal of Experimental & Clinical Cancer Research 2013 32:89

    Published on: 11 November 2013

  35. Review

    Emerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approach

    In 2013 there will be an estimated 22,240 new diagnoses and 14,030 deaths from ovarian cancer in the United States. Despite the improved surgical approach and the novel active drugs that are available today in...

    Federica Tomao, Anselmo Papa, Luigi Rossi, Martina Strudel, Patrizia Vici, Giuseppe Lo Russo and Silverio Tomao

    Journal of Experimental & Clinical Cancer Research 2013 32:48

    Published on: 1 August 2013

  36. Review

    Breast cancer susceptibility gene 1 (BRCA1) predict clinical outcome in platinum- and toxal-based chemotherapy in non-small-cell lung cancer (NSCLC) patients: a system review and meta-analysis

    The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results wer...

    Yanlong Yang, Yuanliang Xie and Lei Xian

    Journal of Experimental & Clinical Cancer Research 2013 32:15

    Published on: 15 March 2013

  37. Review

    Prognostic significance of Cdx2 immunohistochemical expression in gastric cancer: a meta-analysis of published literatures

    Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early int...

    Xiao-Tong Wang, Wei-Yuan Wei, Fan-Biao Kong, Chao Lian, Wen Luo, Qiang Xiao and Yu-Bo Xie

    Journal of Experimental & Clinical Cancer Research 2012 31:98

    Published on: 26 November 2012

  38. Review

    Updates on HIPK2: a resourceful oncosuppressor for clearing cancer

    Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therap...

    Gabriella D’Orazi, Cinzia Rinaldo and Silvia Soddu

    Journal of Experimental & Clinical Cancer Research 2012 31:63

    Published on: 13 August 2012

  39. Review

    Circulating microRNAs in cancer: origin, function and application

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level. The dysregulation of miRNAs has been linked to a series of diseases, including various ty...

    Ruimin Ma, Tao Jiang and Xixiong Kang

    Journal of Experimental & Clinical Cancer Research 2012 31:38

    Published on: 30 April 2012

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