Brain resilience is the process of adapting well in the face of significant sources of stress, such as Alzheimer’s disease pathology, other neurodegenerative conditions or biological aging. This thematic series entitled “Resilience in dementia” comprises nine articles covering a wide range of topics, including concepts related to resilience (e.g. brain reserve, cognitive reserve and brain maintenance), its underlying mechanisms (e.g. left frontal cortex functional connectivity) and consequences for disease trajectories (e.g. rates of progression to dementia). The contributions span from perspective papers to strictly data-driven articles and range from cell/animal models, to cognitively normal individuals to clinical populations. Altogether, this thematic series provides a comprehensive overview of what factors contribute to brain resilience and how this affects brain health and cognitive function.
Guest Editor: Rik Ossenkoppele