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Research highlights

Recent Research highlights published in Genome Biology

This list will be updated with all our new Research highlights. Genome Biology publishes Research highlights that are open access and therefore free to read and share.

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  1. Genome-scale models require an objective function representing what an organism strives for. A method has been developed to infer this fundamental biological function from data.

    Authors: Adam M. Feist and Bernhard O. Palsson
    Citation: Genome Biology 2016 17:110
  2. A new study shows how RNA-induced silencing complex (RISC)-mediated posttranscriptional regulation of chromatin remodelers allows for tight control of the naïve-to-primed pluripotency transition.

    Authors: Diana Guallar and Jianlong Wang
    Citation: Genome Biology 2016 17:104
  3. Protein complexes are dynamic. A new analysis of two quantitative proteomic datasets reveals cell type-specific changes in the stoichiometry of complexes, which often involve paralog switching.

    Authors: Michael P. Washburn
    Citation: Genome Biology 2016 17:48
  4. DeRisi and colleagues present a creative application for Cas9 in vitro, using it to deplete unwanted sequence from DNA libraries. It seems plausible that the in vitro use of CRISPR/Cas9 has unrealized potentia...

    Authors: Vijay Ramani and Jay Shendure
    Citation: Genome Biology 2016 17:42
  5. A new study shows that genomic introgression between two Heliconius butterfly species is not solely confined to color pattern loci.

    Authors: Richard H. Ffrench-Constant
    Citation: Genome Biology 2016 17:30
  6. A recent super-resolution imaging study by Boettiger et al. elegantly demonstrates that three epigenetically defined, and functionally disparate, chromatin states have distinct folding characteristics in Drosophi...

    Authors: Iain Williamson, Wendy A. Bickmore and Robert S. Illingworth
    Citation: Genome Biology 2016 17:35
  7. A new study uses genomics to show that fusions of plant immune receptors and other protein domains occur in significant numbers. This finding will generate many new research hypotheses and provide new opportun...

    Authors: Simon G. Krattinger and Beat Keller
    Citation: Genome Biology 2016 17:23
  8. A new study shows how a single cytokine, interleukin-4, regulates hematopoietic lineage choice by activating the JAK3–STAT6 pathway, which causes dendritic-cell-specific DNA demethylation.

    Authors: Andreas Lennartsson
    Citation: Genome Biology 2016 17:18
  9. Alu elements can integrate into human genes and lead to the generation of primate-specific isoforms. A new study examines their contribution to the human proteome.

    Authors: Eli Eisenberg
    Citation: Genome Biology 2016 17:17
  10. By performing high-throughput chromosome conformation capture analyses in embryonic stem cells depleted of the linker histone H1, Geeven and colleagues have uncovered exciting new evidence concerning a role fo...

    Authors: Annalisa Izzo and Robert Schneider
    Citation: Genome Biology 2016 17:8