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Research highlights

Recent Research highlights published in Genome Biology

This list will be updated with all our new Research highlights. Genome Biology publishes Research highlights that are open access and therefore free to read and share.

  1. Content type: Research Highlight

    Balancing selection maintains variation for evolution. A recent study investigated the extent of balancing selection in two Brassicaceae species and highlighted its importance for adaptation.

    Authors: Baosheng Wang and Thomas Mitchell-Olds

    Citation: Genome Biology 2017 18:231

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  2. Content type: Research Highlight

    Epigenetic profiling in diploid, allopolyploid, and domesticated cotton shows that despite most DNA methylation being conserved and stably inherited, alterations likely due to hybridization and domestication a...

    Authors: Scott A. Jackson

    Citation: Genome Biology 2017 18:117

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  3. Content type: Research Highlight

    Epigenetic clocks provide powerful tools to evaluate nutritional, hormonal, and genetic effects on aging. What can we learn from differences between species in how these clocks tick?

    Authors: Wolfgang Wagner

    Citation: Genome Biology 2017 18:107

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  4. Content type: Research Highlight

    Two recent studies demonstrate the power of integrating tumor genotype information with epigenetic and proteomic studies to discover potential therapeutic targets in breast cancer.

    Authors: Gabriel J. Sandoval and William C. Hahn

    Citation: Genome Biology 2017 18:95

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  5. Content type: Research Highlight

    A recently published study in Genome Biology shows that cells isolated from cryopreserved tissues are a reliable source of genetic material for single-cell RNA-sequencing experiments.

    Authors: Felipe A. Vieira Braga, Sarah A. Teichmann and Michael J. T. Stubbington

    Citation: Genome Biology 2017 18:54

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  6. Content type: Research Highlight

    Selection-free genome editing using Cas9 ribonucleoprotein embryo bombardment has been achieved for maize and wheat. This is a breakthrough that should make new breeding technologies more acceptable for worldw...

    Authors: Felix Wolter and Holger Puchta

    Citation: Genome Biology 2017 18:43

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  7. Content type: Research Highlight

    Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of...

    Authors: Toni Celià-Terrassa and Yibin Kang

    Citation: Genome Biology 2017 18:31

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  8. Content type: Research Highlight

    Alternative splice isoforms are common and important and have been shown to impact many human diseases. A new study by Nellore et al. offers a comprehensive study of splice junctions in humans by re-analyzing ...

    Authors: Christelle Robert and Mick Watson

    Citation: Genome Biology 2016 17:265

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  9. Content type: Research Highlight

    A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.

    Authors: Brock C. Christensen and Karl T. Kelsey

    Citation: Genome Biology 2016 17:216

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  10. Content type: Research Highlight

    Schmitz and colleagues recently investigated DNA methylation patterns in diverse flowering plant species, finding substantial variation in the extent and distribution of methylation in angiosperms.

    Authors: Mary Gehring

    Citation: Genome Biology 2016 17:197

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  11. Content type: Research Highlight

    The search for novel ways to target and alter the genomes of living organisms accelerated rapidly this decade with the discovery of CRISPR/Cas9. Since the initial discovery, efforts to find alternative methods...

    Authors: Gaurav K. Varshney and Shawn M. Burgess

    Citation: Genome Biology 2016 17:187

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  12. Content type: Research Highlight

    Understanding a tumor’s complex cellular heterogeneity will be crucial for the development of better treatment strategies. A new study suggests a novel method for the in silico dissociation of solid tumors and...

    Authors: Dvir Aran and Atul J. Butte

    Citation: Genome Biology 2016 17:175

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  13. Content type: Research Highlight

    An association between hammerhead ribozymes and non-autonomous, long terminal repeat retrotransposons is uncovered in plants, shedding light on the biological function of genomically encoded ribozymes.

    Authors: Christian Hammann

    Citation: Genome Biology 2016 17:136

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  14. Content type: Research Highlight

    Computational methods have been developed to reconstruct evolutionary lineages from tumors using single-cell genomic data. The resulting tumor trees have important applications in cancer research and clinical ...

    Authors: Alexander Davis and Nicholas E. Navin

    Citation: Genome Biology 2016 17:113

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  15. Content type: Research Highlight

    Genome-scale models require an objective function representing what an organism strives for. A method has been developed to infer this fundamental biological function from data.

    Authors: Adam M. Feist and Bernhard O. Palsson

    Citation: Genome Biology 2016 17:110

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  16. Content type: Research Highlight

    A new study shows how RNA-induced silencing complex (RISC)-mediated posttranscriptional regulation of chromatin remodelers allows for tight control of the naïve-to-primed pluripotency transition.

    Authors: Diana Guallar and Jianlong Wang

    Citation: Genome Biology 2016 17:104

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  17. Content type: Research Highlight

    Protein complexes are dynamic. A new analysis of two quantitative proteomic datasets reveals cell type-specific changes in the stoichiometry of complexes, which often involve paralog switching.

    Authors: Michael P. Washburn

    Citation: Genome Biology 2016 17:48

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  18. Content type: Research Highlight

    DeRisi and colleagues present a creative application for Cas9 in vitro, using it to deplete unwanted sequence from DNA libraries. It seems plausible that the in vitro use of CRISPR/Cas9 has unrealized potentia...

    Authors: Vijay Ramani and Jay Shendure

    Citation: Genome Biology 2016 17:42

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  19. Content type: Research Highlight

    A new study shows that genomic introgression between two Heliconius butterfly species is not solely confined to color pattern loci.

    Authors: Richard H. Ffrench-Constant

    Citation: Genome Biology 2016 17:30

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  20. Content type: Research Highlight

    A recent super-resolution imaging study by Boettiger et al. elegantly demonstrates that three epigenetically defined, and functionally disparate, chromatin states have distinct folding characteristics in Drosophi...

    Authors: Iain Williamson, Wendy A. Bickmore and Robert S. Illingworth

    Citation: Genome Biology 2016 17:35

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  21. Content type: Research Highlight

    A new study uses genomics to show that fusions of plant immune receptors and other protein domains occur in significant numbers. This finding will generate many new research hypotheses and provide new opportun...

    Authors: Simon G. Krattinger and Beat Keller

    Citation: Genome Biology 2016 17:23

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  22. Content type: Research Highlight

    A new study shows how a single cytokine, interleukin-4, regulates hematopoietic lineage choice by activating the JAK3–STAT6 pathway, which causes dendritic-cell-specific DNA demethylation.

    Authors: Andreas Lennartsson

    Citation: Genome Biology 2016 17:18

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  23. Content type: Research Highlight

    Alu elements can integrate into human genes and lead to the generation of primate-specific isoforms. A new study examines their contribution to the human proteome.

    Authors: Eli Eisenberg

    Citation: Genome Biology 2016 17:17

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  24. Content type: Research Highlight

    By performing high-throughput chromosome conformation capture analyses in embryonic stem cells depleted of the linker histone H1, Geeven and colleagues have uncovered exciting new evidence concerning a role fo...

    Authors: Annalisa Izzo and Robert Schneider

    Citation: Genome Biology 2016 17:8

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