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Research highlights

Recent Research highlights published in Genome Biology

This list will be updated with all our new Research highlights. Genome Biology publishes Research highlights that are open access and therefore free to read and share.

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  1. A recent study on human structural variation indicates insufficiencies and errors in the human reference genome, GRCh38, and argues for the construction of a human pan-genome.

    Authors: Xiaofei Yang, Wan-Ping Lee, Kai Ye and Charles Lee
    Citation: Genome Biology 2019 20:104
  2. Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus rem...

    Authors: Stella Maxouri, Stavros Taraviras and Zoi Lygerou
    Citation: Genome Biology 2018 19:182
  3. We discuss a recent study that has identified and validated the link between a type-2 diabetes (T2D) association and human adipose biology by means of KLF14 gene expression. In addition to being maternally imprin...

    Authors: Kim Lorenz and Benjamin F. Voight
    Citation: Genome Biology 2018 19:74
  4. The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into p...

    Authors: Gaetan Burgio
    Citation: Genome Biology 2018 19:27

    The Correction to this article has been published in Genome Biology 2018 19:41

  5. Balancing selection maintains variation for evolution. A recent study investigated the extent of balancing selection in two Brassicaceae species and highlighted its importance for adaptation.

    Authors: Baosheng Wang and Thomas Mitchell-Olds
    Citation: Genome Biology 2017 18:231
  6. Concentration is important and not only while driving; a new study indicates how an adjacent genomic element helps to increase the efficiency of a specific adenosine to inosine RNA editing reaction, by providi...

    Authors: Miri Danan-Gotthold and Erez Y. Levanon
    Citation: Genome Biology 2017 18:196
  7. Epigenetic profiling in diploid, allopolyploid, and domesticated cotton shows that despite most DNA methylation being conserved and stably inherited, alterations likely due to hybridization and domestication a...

    Authors: Scott A. Jackson
    Citation: Genome Biology 2017 18:117
  8. Epigenetic clocks provide powerful tools to evaluate nutritional, hormonal, and genetic effects on aging. What can we learn from differences between species in how these clocks tick?

    Authors: Wolfgang Wagner
    Citation: Genome Biology 2017 18:107
  9. Two recent studies demonstrate the power of integrating tumor genotype information with epigenetic and proteomic studies to discover potential therapeutic targets in breast cancer.

    Authors: Gabriel J. Sandoval and William C. Hahn
    Citation: Genome Biology 2017 18:95
  10. A recently published study in Genome Biology shows that cells isolated from cryopreserved tissues are a reliable source of genetic material for single-cell RNA-sequencing experiments.

    Authors: Felipe A. Vieira Braga, Sarah A. Teichmann and Michael J. T. Stubbington
    Citation: Genome Biology 2017 18:54
  11. Selection-free genome editing using Cas9 ribonucleoprotein embryo bombardment has been achieved for maize and wheat. This is a breakthrough that should make new breeding technologies more acceptable for worldw...

    Authors: Felix Wolter and Holger Puchta
    Citation: Genome Biology 2017 18:43
  12. Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of...

    Authors: Toni Celià-Terrassa and Yibin Kang
    Citation: Genome Biology 2017 18:31
  13. Alternative splice isoforms are common and important and have been shown to impact many human diseases. A new study by Nellore et al. offers a comprehensive study of splice junctions in humans by re-analyzing ...

    Authors: Christelle Robert and Mick Watson
    Citation: Genome Biology 2016 17:265
  14. A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.

    Authors: Brock C. Christensen and Karl T. Kelsey
    Citation: Genome Biology 2016 17:216
  15. Schmitz and colleagues recently investigated DNA methylation patterns in diverse flowering plant species, finding substantial variation in the extent and distribution of methylation in angiosperms.

    Authors: Mary Gehring
    Citation: Genome Biology 2016 17:197
  16. The search for novel ways to target and alter the genomes of living organisms accelerated rapidly this decade with the discovery of CRISPR/Cas9. Since the initial discovery, efforts to find alternative methods...

    Authors: Gaurav K. Varshney and Shawn M. Burgess
    Citation: Genome Biology 2016 17:187
  17. Understanding a tumor’s complex cellular heterogeneity will be crucial for the development of better treatment strategies. A new study suggests a novel method for the in silico dissociation of solid tumors and...

    Authors: Dvir Aran and Atul J. Butte
    Citation: Genome Biology 2016 17:175
  18. An association between hammerhead ribozymes and non-autonomous, long terminal repeat retrotransposons is uncovered in plants, shedding light on the biological function of genomically encoded ribozymes.

    Authors: Christian Hammann
    Citation: Genome Biology 2016 17:136
  19. Computational methods have been developed to reconstruct evolutionary lineages from tumors using single-cell genomic data. The resulting tumor trees have important applications in cancer research and clinical ...

    Authors: Alexander Davis and Nicholas E. Navin
    Citation: Genome Biology 2016 17:113