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Research highlights

Recent Research highlights published in Genome Biology

This list will be updated with all our new Research highlights. Genome Biology publishes Research highlights that are open access and therefore free to read and share.

  1. Research Highlight

    Epigenomics: dissecting hybridization and polyploidization

    Epigenetic profiling in diploid, allopolyploid, and domesticated cotton shows that despite most DNA methylation being conserved and stably inherited, alterations likely due to hybridization and domestication a...

    Scott A. Jackson

    Genome Biology 2017 18:117

    Published on: 19 June 2017

  2. Research Highlight

    Epigenetic aging clocks in mice and men

    Epigenetic clocks provide powerful tools to evaluate nutritional, hormonal, and genetic effects on aging. What can we learn from differences between species in how these clocks tick?

    Wolfgang Wagner

    Genome Biology 2017 18:107

    Published on: 14 June 2017

  3. Research Highlight

    Going beyond genetics to discover cancer targets

    Two recent studies demonstrate the power of integrating tumor genotype information with epigenetic and proteomic studies to discover potential therapeutic targets in breast cancer.

    Gabriel J. Sandoval and William C. Hahn

    Genome Biology 2017 18:95

    Published on: 22 May 2017

  4. Research Highlight

    Mouse genomic screen reveals novel host regulator of metastasis

    Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of...

    Toni Celià-Terrassa and Yibin Kang

    Genome Biology 2017 18:31

    Published on: 16 February 2017

  5. Research Highlight

    The incredible complexity of RNA splicing

    Alternative splice isoforms are common and important and have been shown to impact many human diseases. A new study by Nellore et al. offers a comprehensive study of splice junctions in humans by re-analyzing ...

    Christelle Robert and Mick Watson

    Genome Biology 2016 17:265

    Published on: 30 December 2016

  6. Research Highlight

    TET enzymes: double agents in the transposable element–host genome conflict

    The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticate...

    Patricia Gerdes, Sandra R. Richardson and Geoffrey J. Faulkner

    Genome Biology 2016 17:259

    Published on: 20 December 2016

  7. Research Highlight

    A new timepiece: an epigenetic mitotic clock

    A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.

    Brock C. Christensen and Karl T. Kelsey

    Genome Biology 2016 17:216

    Published on: 19 October 2016

  8. Research Highlight

    DNA replication stress: a source of APOBEC3B expression in breast cancer

    APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new experimental study sheds light on the inciting fac...

    David W. Cescon and Benjamin Haibe-Kains

    Genome Biology 2016 17:202

    Published on: 30 September 2016

  9. Research Highlight

    Prodigious plant methylomes

    Schmitz and colleagues recently investigated DNA methylation patterns in diverse flowering plant species, finding substantial variation in the extent and distribution of methylation in angiosperms.

    Mary Gehring

    Genome Biology 2016 17:197

    Published on: 27 September 2016

  10. Research Highlight

    DNA-guided genome editing using structure-guided endonucleases

    The search for novel ways to target and alter the genomes of living organisms accelerated rapidly this decade with the discovery of CRISPR/Cas9. Since the initial discovery, efforts to find alternative methods...

    Gaurav K. Varshney and Shawn M. Burgess

    Genome Biology 2016 17:187

    Published on: 15 September 2016

  11. Research Highlight

    Digitally deconvolving the tumor microenvironment

    Understanding a tumor’s complex cellular heterogeneity will be crucial for the development of better treatment strategies. A new study suggests a novel method for the in silico dissociation of solid tumors and...

    Dvir Aran and Atul J. Butte

    Genome Biology 2016 17:175

    Published on: 22 August 2016

  12. Research Highlight

    Hammerhead ribozymes going viral

    An association between hammerhead ribozymes and non-autonomous, long terminal repeat retrotransposons is uncovered in plants, shedding light on the biological function of genomically encoded ribozymes.

    Christian Hammann

    Genome Biology 2016 17:136

    Published on: 23 June 2016

  13. Research Highlight

    Computing tumor trees from single cells

    Computational methods have been developed to reconstruct evolutionary lineages from tumors using single-cell genomic data. The resulting tumor trees have important applications in cancer research and clinical ...

    Alexander Davis and Nicholas E. Navin

    Genome Biology 2016 17:113

    Published on: 26 May 2016

  14. Research Highlight

    What do cells actually want?

    Genome-scale models require an objective function representing what an organism strives for. A method has been developed to infer this fundamental biological function from data.

    Adam M. Feist and Bernhard O. Palsson

    Genome Biology 2016 17:110

    Published on: 23 May 2016

  15. Research Highlight

    Taking the RISC of exiting naïve pluripotency

    A new study shows how RNA-induced silencing complex (RISC)-mediated posttranscriptional regulation of chromatin remodelers allows for tight control of the naïve-to-primed pluripotency transition.

    Diana Guallar and Jianlong Wang

    Genome Biology 2016 17:104

    Published on: 16 May 2016

  16. Research Highlight

    The shocking consequences of hybrid epigenomes

    The formation of spontaneous epialleles is poorly understood. A new study describes how the formation of epihybrids can lead to the appearance of novel epialleles.

    William T. Jordan and Robert J. Schmitz

    Genome Biology 2016 17:85

    Published on: 5 May 2016

    The Erratum to this article has been published in Genome Biology 2016 17:165

  17. Research Highlight

    Single-cell profiling of lncRNAs in the developing human brain

    Single-cell RNA-seq in samples from the human neocortex demonstrate that long noncoding RNAs (lncRNAs) are abundantly expressed in specific individual brain cells, despite being hard to detect in bulk samples....

    Qing Ma and Howard Y. Chang

    Genome Biology 2016 17:68

    Published on: 14 April 2016

  18. Research Highlight

    There is no human interactome

    Protein complexes are dynamic. A new analysis of two quantitative proteomic datasets reveals cell type-specific changes in the stoichiometry of complexes, which often involve paralog switching.

    Michael P. Washburn

    Genome Biology 2016 17:48

    Published on: 14 March 2016

  19. Research Highlight

    Smash and DASH with Cas9

    DeRisi and colleagues present a creative application for Cas9 in vitro, using it to deplete unwanted sequence from DNA libraries. It seems plausible that the in vitro use of CRISPR/Cas9 has unrealized potentia...

    Vijay Ramani and Jay Shendure

    Genome Biology 2016 17:42

    Published on: 5 March 2016

  20. Research Highlight

    Butterfly gene flow goes berserk

    A new study shows that genomic introgression between two Heliconius butterfly species is not solely confined to color pattern loci.

    Richard H. Ffrench-Constant

    Genome Biology 2016 17:30

    Published on: 27 February 2016

  21. Research Highlight

    Polycomb-mediated chromatin compaction weathers the STORM

    A recent super-resolution imaging study by Boettiger et al. elegantly demonstrates that three epigenetically defined, and functionally disparate, chromatin states have distinct folding characteristics in Drosophi...

    Iain Williamson, Wendy A. Bickmore and Robert S. Illingworth

    Genome Biology 2016 17:35

    Published on: 25 February 2016

  22. Research Highlight

    External signals shape the epigenome

    A new study shows how a single cytokine, interleukin-4, regulates hematopoietic lineage choice by activating the JAK3–STAT6 pathway, which causes dendritic-cell-specific DNA demethylation.

    Andreas Lennartsson

    Genome Biology 2016 17:18

    Published on: 1 February 2016

  23. Research Highlight

    Proteome diversification by genomic parasites

    Alu elements can integrate into human genes and lead to the generation of primate-specific isoforms. A new study examines their contribution to the human proteome.

    Eli Eisenberg

    Genome Biology 2016 17:17

    Published on: 30 January 2016

  24. Research Highlight

    H1 gets the genome in shape

    By performing high-throughput chromosome conformation capture analyses in embryonic stem cells depleted of the linker histone H1, Geeven and colleagues have uncovered exciting new evidence concerning a role fo...

    Annalisa Izzo and Robert Schneider

    Genome Biology 2016 17:8

    Published on: 18 January 2016