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Reducing financial hardships from cancers

Study protocols of NIH funded trials

Edited by: Dr Matthew Banegas and Dr Janet S. de Moor

Financial hardship is a common experience for cancer patients and their families; however, few interventions have been developed to mitigate the economic burden of cancer and its treatment. This article collection in Trials addresses these gaps in the literature. It includes articles reporting on patient-facing interventions to address different aspects of cancer-related financial hardship. Each article describes a pragmatic study, designed to evaluate the effectiveness of the intervention in real-life practice conditions. Three of the five studies evaluate personalized financial navigation, testing the effectiveness of navigation embedded into the oncology or community setting. Two additional trials are evaluating interventions to address important contributors to cancer-related financial hardship, namely health insurance coverage and employment disruption. Collectively these five interventions will add substantially to what is known about evidence-based approaches for addressing the economic burden of cancer. They represent different intervention designs and modes of intervention delivery, thus providing important templates for future interventions to address financial hardship.

  1. Cancer is a medical condition where some cells of the body reproduce uncontrollably and metastasize to other parts of the body. The burden of the disease is significantly high both at the global and national l...

    Authors: Fatima Abdul Rashid, Wajiha Anwar, Praveen Kumar Kandakurti and Animesh Hazari
    Citation: Trials 2024 25:354
  2. Job loss after a cancer diagnosis can lead to long-term financial toxicity and its attendant adverse clinical consequences, including decreased treatment adherence. Among women undergoing (neo)adjuvant chemoth...

    Authors: Victoria S. Blinder, Sujata Patil, Jackie Finik, Della Makower, Monica Muppidi, Wendy G. Lichtenthal, Patricia A. Parker, Maria Claros, Jennifer Suarez, Bharat Narang and Francesca Gany
    Citation: Trials 2022 23:840
  3. Almost half of the patients with cancer report cancer-related financial hardship, termed “financial toxicity” (FT), which affects health-related quality of life, care retention, and, in extreme cases, mortalit...

    Authors: Stephanie B. Wheeler, Caitlin B. Biddell, Michelle L. Manning, Mindy S. Gellin, Neda R. Padilla, Lisa P. Spees, Cynthia D. Rogers, Julia Rodriguez-O’Donnell, Cleo Samuel-Ryals, Sarah A. Birken, Katherine E. Reeder-Hayes, Victoria M. Petermann, Allison M. Deal and Donald L. Rosenstein
    Citation: Trials 2022 23:839
  4. For adolescent and young adult (AYA) cancer patients aged 18 to 39 years, health insurance literacy is crucial for an effective use of the health care system. AYAs often face high out-of-pocket costs or have u...

    Authors: Karely Mann, Austin R. Waters, Elyse R. Park, Giselle K. Perez, Perla L. Vaca Lopez, Heydon K. Kaddas, Echo L. Warner, Nicole Ray, Tomoko Tsukamoto, Karlie Allen, Ben Haaland, Douglas B. Fair, Mark A. Lewis and Anne C. Kirchhoff
    Citation: Trials 2022 23:682
  5. There is an urgent need for evidence on how interventions can prevent or mitigate cancer-related financial hardship. Our objectives are to compare self-reported financial hardship, quality of life, and health ...

    Authors: Nora B. Henrikson, Melissa L. Anderson, John Dickerson, John J. Ewing, Robin Garcia, Erin Keast, Deborah A. King, Cara Lewis, Blake Locher, Carmit McMullen, Consuelo M. Norris, Amanda F. Petrik, Arvind Ramaprasan, Jennifer S. Rivelli, Jennifer L. Schneider, Lisa Shulman…
    Citation: Trials 2022 23:402