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Perivascular adipose tissue: friend or foe in cardiometabolic disorders

Edited by:

Cristina Sena, PhD, University of Coimbra, Portugal

Submission Status: Open   |   Submission Deadline: 31 January 2025

Cardiovascular Diabetology is calling for submissions to our Collection on Perivascular adipose tissue: friend or foe in cardiometabolic disorders.

Image credit: Cristina Sena

New Content ItemThis Collection supports and amplifies research related to SDG 3: Good health and well-being.

About the Collection

Cardiovascular Diabetology is calling for submissions to our Collection on Perivascular adipose tissue: friend or foe in cardiometabolic disorders. Perivascular adipose tissue (PVAT) has been identified as a key mediator in the maintenance of vascular homeostasis since the groundbreaking work of Soltis and Cassis (1991). PVAT present in the majority of blood vessels throughout the body (with the exception of cerebral and pulmonary arteries), demonstrates regional variations and heterogeneity along the vascular network. Furthermore, PVAT comprises diverse cell types beyond adipocytes. The interconnection between PVAT and blood vessel wall cells is vital for normal vascular function. Recently considered a biomarker and target in pathologic conditions such as atherosclerosis PVAT changes its phenotype under pathologic conditions such as obesity and diabetes. Aging is another factor that modifies this tissue.

Hence, the aims of this collection are to highlight:

1) The importance of PVAT in cardiovascular disease, whether in the presence or absence of diabetes.

2) The involvement of PVAT and its heightened impact on arterial stiffness during aging and various diseases.

3) The translational potential of PVAT as an innovative therapeutic target in clinical contexts.

For this collection, papers on diabetes, cardiovascular disease, aging, perivascular adipose tissue, obesity, arterial stiffness, gut microbiome, hypercholesterolemia, cholesterol, heart failure, exercise, nutraceuticals, diet, ketogenic diet, oxidative stress, and inflammation are welcome. Along these lines reinforcing the role and mechanisms of PVAT in cardiometabolic diseases is imperative and will help to explain heterogeneity in different vascular beds.

Furthermore, exploration into the impact of perivascular adipose tissue (PVAT) on arterial stiffening remains in its early stages, providing limited understanding of this aspect of arterial health. Studies conducted on aging, obesity, and heart failure in preclinical models have directly shown that PVAT promotes or contributes to arterial stiffness. These findings also offer preliminary insights into potential novel targets for intervention. However, there are few interventions that effectively modify the PVAT phenotype to reduce arterial stiffness. A practical approach to bridging preclinical discoveries with clinical applications and establishing PVAT as a therapeutic target for arterial de-stiffening and overall arterial health involves utilizing clinical imaging techniques. For this collection all types of articles are welcome (research articles, commentaries, review articles…).

There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of research articles, commentaries, review articles etc. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. 

Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Perivascular adipose tissue: friend or foe in cardiometabolic disorders" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.