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Call for papers: The future of pragmatic trials

Edited by: Prof Marion Campbell and Prof Sandra Eldridge

Trials invites you to submit articles for our new thematic series on “The future of pragmatic trials”.

The Editors will consider articles that report on current understandings of the role and definition of the pragmatic design (including comparative effectiveness research and real world trials), its use and applicability to modern-day healthcare challenges, its relevance to and use with novel trial designs (e.g. cohort multiple, stepped wedge, cluster randomized, registry trials), and considerations of ethical issues (e.g. streamlined research ethics review, patient engagement, different types of consent).

We encourage articles on any topic relevant to the role, definition and use of the pragmatic trial design.  Commentaries and opinion pieces are welcome, especially those looking explicitly to the future use of the pragmatic design. All articles should make explicit and clear the relevance to pragmatic trials and how the results or opinions in the article should be used to improve our understanding and use of the design in the future.

Manuscripts should be formatted according to our submission guidelines and submitted via the online submission system. In the submission system please make sure the correct collection title is chosen from the additional information tab. Please also indicate clearly in the covering letter that the manuscript is to be considered in the ‘The future of pragmatic trials” series.

For further information, please use the contact us email on the journal website.

  1. Pragmatic trials provide the opportunity to study the effectiveness of health interventions to improve care in real-world settings. However, use of open-cohort designs with patients becoming eligible after ran...

    Authors: Jennifer F. Bobb, Hongxiang Qiu, Abigail G. Matthews, Jennifer McCormack and Katharine A. Bradley

    Citation: Trials 2020 21:289

    Content type: Research

    Published on:

  2. We aimed to assess the patient experience of informed consent (IC) during acute myocardial infarction (AMI) in a sub-study of the VALIDATE-SWEDEHEART trial. The original trial compared two anticoagulant agents...

    Authors: Anneli Olsson, Camilla Ring, Johan Josefsson, Annika Eriksson, Rebecca Rylance, Ole Fröbert, Stefan James, David Sparv and David Erlinge

    Citation: Trials 2020 21:246

    Content type: Research

    Published on:

  3. Shared medical appointments (SMAs) have been shown to be an efficient and effective strategy for providing diabetes self-management education and self-management support. SMA features vary and it is not known ...

    Authors: Bethany M. Kwan, L. Miriam Dickinson, Russell E. Glasgow, Martha Sajatovic, Mark Gritz, Jodi Summers Holtrop, Don E. Nease Jr., Natalie Ritchie, Andrea Nederveld, Dennis Gurfinkel and Jeanette A. Waxmonsky

    Citation: Trials 2020 21:65

    Content type: Study protocol

    Published on:

    The Correction to this article has been published in Trials 2020 21:195

  4. Scalp acupuncture has been widely used as treatment for motor dysfunction in children with cerebral palsy in China. Previous studies have failed to provide high-quality evidence to demonstrate the effectivenes...

    Authors: Jun Wang, Wei Shi, Dhiaedin Khiati, Bingpei Shi, Xiaojuan Shi, Dandan Luo, Yin Wang, Rencai Deng, Huayu Huang, Jian Li, Weili Yan and Hong Yang

    Citation: Trials 2020 21:29

    Content type: Study protocol

    Published on:

  5. Building capacity in research funding organizations to support the conduct of pragmatic clinical trials is an essential component of advancing biomedical and public health research. To date, efforts to increas...

    Authors: Wynne E. Norton, Merrick Zwarenstein, Susan Czajkowski, Elisabeth Kato, Ann O’Mara, Nonniekaye Shelburne, David A. Chambers and Kirsty Loudon

    Citation: Trials 2019 20:779

    Content type: Commentary

    Published on:

  6. There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of their actual effectiveness in usual practice. Pragmatic randomized controlled ...

    Authors: Stuart G. Nicholls, Kelly Carroll, Merrick Zwarenstein, Jamie C. Brehaut, Charles Weijer, Spencer P. Hey, Cory E. Goldstein, Ian D. Graham, Jeremy M. Grimshaw, Joanne E. McKenzie, Dean A. Fergusson and Monica Taljaard

    Citation: Trials 2019 20:765

    Content type: Research

    Published on:

  7. Pragmatic trials have been suggested as a way to improve the relevance of clinical trial results to practice. PRECIS-2 (Pragmatic Explanatory Continuum Indicator Summary-2) is a trial design tool which conside...

    Authors: Gordon Forbes, Kirsty Loudon, Megan Clinch, Stephanie J. C. Taylor, Shaun Treweek and Sandra Eldridge

    Citation: Trials 2019 20:711

    Content type: Research

    Published on:

  8. The Pragmatic Trial of Video Education in Nursing Homes (PROVEN) is one of the first large pragmatic randomized clinical trials (pRCTs) to be conducted in U.S. nursing homes (N = 119 intervention and N = 241 cont...

    Authors: Jennifer A. Palmer, Victoria A. Parker, Lacey R. Barre, Vincent Mor, Angelo E. Volandes, Emmanuelle Belanger, Lacey Loomer, Ellen McCreedy and Susan L. Mitchell

    Citation: Trials 2019 20:656

    Content type: Research

    Published on:

  9. Postoperative pulmonary complications (PPCs) are the most common perioperative complications following surgical site infection (SSI). They prolong the hospital stay and increase health care costs. A lung-prote...

    Authors: Xue-Fei Li, Dan Jiang, Yu-Lian Jiang, Hong Yu, Jia-Li Jiang, Lei-Lei He, Xiao-Yun Yang and Hai Yu

    Citation: Trials 2019 20:619

    Content type: Study protocol

    Published on: