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Pollution and Epigenetics

About this collection

From diesel particulates to endocrine disruptors, asbestos, heavy metals to molecules like bisphenol A (BPA), it is becoming increasingly clear that man’s propensity to pollute has significant consequences on human health. Moreover, strong evidence now links such pollution to changes within our epigenomes. In this new thematic series in Clinical Epigenetics, we explore the causes and consequences of pollution on the epigenome, how this may have effects not only on the epigenetics of the individual exposed to such pollution, but also review how this may be further exacerbated by downstream or “transgenerational” inheritance of these epigenetic changes.

Guest Editors: Steven Gray and Wim Vanden Berghe

Submit your research on pollution and epigenetics to Clinical Epigenetics.

  1. According to the “Developmental Origins of Health and Disease” (DOHaD) concept, the early-life environment is a critical period for fetal programming. Given the epidemiological evidence that air pollution expo...

    Authors: N. D. Saenen, D. S. Martens, K. Y. Neven, R. Alfano, H. Bové, B. G. Janssen, H. A. Roels, M. Plusquin, K. Vrijens and T. S. Nawrot

    Citation: Clinical Epigenetics 2019 11:124

    Content type: Review

    Published on:

    The Article to this article has been published in Nature Communications 2019 10:3866

  2. Ambient air pollution is associated with numerous adverse health outcomes, but the underlying mechanisms are not well understood; epigenetic effects including altered DNA methylation could play a role. To eval...

    Authors: Mi Kyeong Lee, Cheng-Jian Xu, Megan U. Carnes, Cody E. Nichols, James M. Ward, Sung Ok Kwon, Sun-Young Kim, Woo Jin Kim and Stephanie J. London

    Citation: Clinical Epigenetics 2019 11:37

    Content type: Research

    Published on:

  3. Neural tube defects (NTDs) are common and severe congenital malformations. Pax3 is an essential gene for neural tube closure in mice but it is unknown whether altered expression or methylation of PAX3 contributes...

    Authors: Shanshan Lin, Aiguo Ren, Linlin Wang, Chloe Santos, Yun Huang, Lei Jin, Zhiwen Li and Nicholas D. E. Greene

    Citation: Clinical Epigenetics 2019 11:13

    Content type: Research

    Published on: