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Integrated modeling and management of poliovirus endgame risks and policies

 

This series of articles by researchers from Kid Risk, Inc. offers critical insights to help national, regional, and global health leaders as they navigate the polio endgame.  The series includes papers that explore the risks of a non-synchronous switch from oral poliovirus vaccine (OPV) containing serotypes 1, 2, and 3 (trivalent OPV or tOPV) to bivalent OPV (bOPV) containing serotypes 1 and 3, and the consequences of inadvertent use of tOPV after the global switch from tOPV-bOPV.  One paper examines different options for responding to outbreaks that may occur during the endgame.  Several papers in the series use a global model developed and applied in one paper to characterize the risks, costs, and benefits of different future poliovirus risk management options for 2013-2052 compared to the 2013 baseline of continued widespread use of OPV. One paper provides estimates of vaccine needs for different OPV formulations in the run up to coordinated OPV cessation of each serotype.  The series includes a paper that shows the importance vaccine choice and of preferentially using tOPV for supplemental immunization activities in the run up to the switch.  One paper reviews the available evidence and characterizes the potential for reintroductions of immunodeficiency-associated vaccine-derived polioviruses.  Another paper explores alternative OPV cessation timing options that represented alternative paths to the current strategy.

 

  1. Content type: Research article

    The endgame for polio eradication includes coordinated global cessation of oral poliovirus vaccine (OPV), starting with the cessation of vaccine containing OPV serotype 2 (OPV2) by switching all trivalent OPV ...

    Authors: Radboud J. Duintjer Tebbens, Lee M. Hampton and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2016 16:237

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  2. Content type: Research article

    The endgame for polio eradication involves coordinated global cessation of oral poliovirus vaccine (OPV) with cessation of serotype 2 OPV (OPV2 cessation) implemented in late April and early May 2016 and cessa...

    Authors: Radboud J. Duintjer Tebbens, Lee M. Hampton and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2016 16:231

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  3. Content type: Research article

    Following successful eradication of wild polioviruses and planned globally-coordinated cessation of oral poliovirus vaccine (OPV), national and global health leaders may need to respond to outbreaks from reint...

    Authors: Radboud J. Duintjer Tebbens, Mark A. Pallansch, Steven G. F. Wassilak, Stephen L. Cochi and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2016 16:137

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  4. Content type: Research article

    The Global Polio Eradication Initiative plans for coordinated cessation of oral poliovirus vaccine (OPV) after interrupting all wild poliovirus (WPV) transmission, but many questions remain related to long-ter...

    Authors: Radboud J. Duintjer Tebbens, Mark A. Pallansch, Stephen L. Cochi, Steven G.F. Wassilak and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2015 15:389

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  5. Content type: Research article

    The Global Polio Eradication Initiative plans for coordinated cessation of oral poliovirus vaccine (OPV) use, beginning with serotype 2-containing OPV (i.e., OPV2 cessation) followed by the remaining two OPV s...

    Authors: Radboud J. Duintjer Tebbens and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2015 15:390

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  6. Content type: Research article

    A small number of individuals with B-cell-related primary immunodeficiency diseases (PIDs) may exhibit long-term (prolonged or chronic) excretion of immunodeficiency-associated vaccine-derived polioviruses (iV...

    Authors: Radboud J. Duintjer Tebbens, Mark A. Pallansch and Kimberly M. Thompson

    Citation: BMC Infectious Diseases 2015 15:379

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  7. Content type: Research article

    Prior analyses demonstrated the need for some countries and the Global Polio Eradication Initiative (GPEI) to conduct additional supplemental immunization activities (SIAs) with trivalent oral poliovirus vacci...

    Authors: Kimberly M. Thompson and Radboud J. Duintjer Tebbens

    Citation: BMC Infectious Diseases 2015 15:376

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  8. Content type: Research article

    World leaders remain committed to globally-coordinated oral poliovirus vaccine (OPV) cessation following successful eradication of wild polioviruses, but the best timing and strategy for implementation depend ...

    Authors: Kimberly M. Thompson and Radboud J. Duintjer Tebbens

    Citation: BMC Infectious Diseases 2015 15:374

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