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Management of Periprosthetic Joint Infection after Arthroplasty

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Periprosthetic joint infection (PJI) remains one of the most challenging and devastating modes of failure following arthroplasty procedures. PJI may lead to a prolonged inpatient stay, substantial economic burden, and high morbidities and mortalities. 

PJI was diagnosed based on a combination of clinical, imaging, laboratory, microbiological, histopathological, and intraoperative findings. The misinterpretation of PJI frequently leads to an erroneous or delayed diagnosis, extra tests, neglected interventions, and unnecessary therapies. Currently, despite the profound urgency and impact of PJI on individuals and societal basis, there is no unified protocol for prevention, diagnosis, and management of PJI. 

This special issue of Arthroplasty is meant to consolidate the latest knowledge and understanding of PJI. This Research Topics also provide open platform for demonstrating novel ideas and insights into PJI, from fundamental etiological research to cutting-edge clinical studies.

This special issue was published in Arthroplasty.

  1. Excellent revisions about antibiotic-loaded bone cement (ALBC) have been recently published. In the present article, we review the principles and limitations of local antibiotic delivery in the context of rece...

    Authors: Marta Sabater-Martos, Miguel A. Verdejo, Laura Morata, Ernesto Muñoz-Mahamud, Ernesto Guerra-Farfan, Juan C. Martinez-Pastor and Alex Soriano
    Citation: Arthroplasty 2023 5:12
  2. Prosthetic joint infection (PJI) is one of the most devastating complications of orthopedic surgery. However, not all patients are equally at the risk of severe infection. The incidences of PJI vary with the h...

    Authors: Christof Berberich, Jerôme Josse and Pablo Sanz Ruiz
    Citation: Arthroplasty 2022 4:41
  3. The study aimed to compare debridement, antibiotics, and implant retention (DAIR) vs. debridement antibiotic bead and retention of the implant (DABRI) in terms of infection-free success rate and treatment cost fo...

    Authors: Gianluca Piovan, Luca Farinelli, Daniele Screpis, Stefania Marocco, Leonardo Motta, Giuseppe Palazzolo, Simone Natali and Claudio Zorzi
    Citation: Arthroplasty 2022 4:42
  4. Periprosthetic joint infection remains a significant challenge for arthroplasty surgeons globally. Over the last few decades, there has been much advancement in terms of treatment and diagnosis, however, the f...

    Authors: Humza M. Mian, Joseph G. Lyons, Joshua Perrin, Andrew W. Froehle and Anil B. Krishnamurthy
    Citation: Arthroplasty 2022 4:31
  5. Periprosthetic joint infection (PJI) is a devastating complication of joint arthroplasty surgery. Treatment success depends on accurate diagnostics, adequate surgical experience and interdisciplinary consultat...

    Authors: W. P. Zijlstra, J. J. W. Ploegmakers, G. A. Kampinga, M. L. Toren-Wielema, H. B. Ettema, B. A. S. Knobben, P. C. Jutte and M. Wouthuyzen-Bakker
    Citation: Arthroplasty 2022 4:19
  6. Periprosthetic joint infection (PJI) is a serious complication of orthopedic arthroplasty surgery. Rat bite fever is a rare infection with Streptobacillus moniliformis (S. moniliformis). Rat bite fever can lead t...

    Authors: Anne Theunis Fokkema, Linda Martine Kampschreur, Loredana Elena Pirii and Wierd Pieter Zijlstra
    Citation: Arthroplasty 2022 4:13
  7. Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii, a strictly intracellular pathogen that can cause acute and chronic infection. Chronic Q fever can occur in immunocompetent as well as in im...

    Authors: Patrick Miailhes, Anne Conrad, Chantal Sobas, Frederic Laurent, Sebastien Lustig and Tristan Ferry
    Citation: Arthroplasty 2021 3:43