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Physical influences on stem cells

Edited by Gordana Vunjak-Novakovic

An article collection in Stem Cell Research & Therapy.

This series covers biophysical regulation of stem cell fate and function in the context of tissue development.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editor and Editors declare no competing interests.

View all collections published in Stem Cell Research & Therapy

  1. Content type: Review

    Bones adapt to accommodate the physical forces they experience through changes in architecture and mass. Stem cells differentiate into bone-forming osteoblasts, and mechanical stimulation is involved in this p...

    Authors: Julia C Chen and Christopher R Jacobs

    Citation: Stem Cell Research & Therapy 2013 4:107

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  2. Content type: Review

    Advances in the fields of stem cell biology, biomaterials, and tissue engineering over the last decades have brought the possibility of constructing tissue substitutes with a broad range of applications in reg...

    Authors: Giuseppe Maria de Peppo and Darja Marolt

    Citation: Stem Cell Research & Therapy 2013 4:106

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  3. Content type: Research

    Obesity, which is excessive expansion of white adipose tissue, is a major risk factor for several serious health issues, including diabetes, cardiovascular disease and cancer. Efforts to combat obesity and rel...

    Authors: Zachary A Schiller, Nathan R Schiele, James K Sims, Kyongbum Lee and Catherine K Kuo

    Citation: Stem Cell Research & Therapy 2013 4:79

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  4. Content type: Review

    Mechanical factors play a crucial role in the development of articular cartilage in vivo. In this regard, tissue engineers have sought to leverage native mechanotransduction pathways to enhance in vitro stem cell...

    Authors: Christopher J O’Conor, Natasha Case and Farshid Guilak

    Citation: Stem Cell Research & Therapy 2013 4:61

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  5. Content type: Review

    Invariant left-right (LR) patterning or chirality is critical for embryonic development. The loss or reversal of LR asymmetry is often associated with malformations and disease. Although several theories have ...

    Authors: Leo Q Wan, Kacey Ronaldson, Mark Guirguis and Gordana Vunjak-Novakovic

    Citation: Stem Cell Research & Therapy 2013 4:24

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  6. Content type: Review

    Bone is a load-bearing tissue and physical forces play key roles in the development and maintenance of its structure. Mechanical cues can stimulate the expression of an osteogenic phenotype, enhance matrix and...

    Authors: Ben P Hung, Daphne L Hutton and Warren L Grayson

    Citation: Stem Cell Research & Therapy 2013 4:10

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  7. Content type: Review

    Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. To maintain their capacities for division and differentiation and thereby build, maintain, and regenerate organ structure ...

    Authors: Anthony Conway and David V Schaffer

    Citation: Stem Cell Research & Therapy 2012 3:50

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  8. Content type: Review

    Controlled expansion and differentiation of pluripotent stem cells (PSCs) using reproducible, high-throughput methods could accelerate stem cell research for clinical therapies. Hydrodynamic culture systems fo...

    Authors: Krista M Fridley, Melissa A Kinney and Todd C McDevitt

    Citation: Stem Cell Research & Therapy 2012 3:45

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  9. Content type: Review

    The assembly of cells into tissues is a complex process controlled by numerous signaling pathways to ensure the fidelity of the final structure. Tissue assembly is also very dynamic, as exemplified by the form...

    Authors: Sriram Manivannan and Celeste M Nelson

    Citation: Stem Cell Research & Therapy 2012 3:42

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  10. Content type: Review

    Stem cells interact with biochemical and biophysical signals in their extracellular environment. The biophysical signals are transduced to the stem cells either through the underlying extracellular matrix or e...

    Authors: Evelyn KF Yim and Michael P Sheetz

    Citation: Stem Cell Research & Therapy 2012 3:41

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