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Personalized medicine in the ICU

Thematic Series

New Content Item

After so many negative randomized, controlled trials, that have evaluated a number of simplified therapeutic interventions that could be applied to large patient populations, people are turning their interest back to personalized medicine.
This new Thematic Series will share thoughts based on scientific data and help the clinician to individualize the different aspects of the patient management.


  1. It is unknown how to titrate positive end-expiratory pressure (PEEP) in patients with COVID-19-related acute respiratory distress syndrome (ARDS). Guidelines recommend the one-size-fits-all PEEP-FiO2 table. In th...

    Authors: Peter Somhorst, Philip van der Zee, Henrik Endeman and Diederik Gommers
    Citation: Critical Care 2022 26:272
  2. Adequate antibiotic dosing may improve outcomes in critically ill patients but is challenging due to altered and variable pharmacokinetics. To address this challenge, AutoKinetics was developed, a decision sup...

    Authors: Luca F. Roggeveen, Tingjie Guo, Lucas M. Fleuren, Ronald Driessen, Patrick Thoral, Reinier M. van Hest, Ron A. A. Mathot, Eleonora L. Swart, Harm-Jan de Grooth, Bas van den Bogaard, Armand R. J. Girbes, Rob J. Bosman and Paul W. G. Elbers
    Citation: Critical Care 2022 26:265
  3. To assess the impact of different electronic relaxation devices on common stressful patient symptoms experienced in intensive care unit (ICU).

    Authors: Lili Merliot-Gailhoustet, Chloé Raimbert, Océane Garnier, Julie Carr, Audrey De Jong, Nicolas Molinari, Samir Jaber and Gerald Chanques
    Citation: Critical Care 2022 26:263
  4. Acute kidney injury (AKI) is a frequently encountered syndrome especially among the critically ill. Current diagnosis of AKI is based on acute deterioration of kidney function, indicated by an increase in crea...

    Authors: Suvi T. Vaara, Pavan K. Bhatraju, Natalja L. Stanski, Blaithin A. McMahon, Kathleen Liu, Michael Joannidis and Sean M. Bagshaw
    Citation: Critical Care 2022 26:251
  5. Trauma is a heterogeneous condition, and specific clinical phenotypes may identify target populations that could benefit from certain treatment strategies. In this retrospective study, we determined clinical p...

    Authors: Jotaro Tachino, Hisatake Matsumoto, Fuminori Sugihara, Shigeto Seno, Daisuke Okuzaki, Tetsuhisa Kitamura, Sho Komukai, Yoshiyuki Kido, Takashi Kojima, Yuki Togami, Yusuke Katayama, Yuko Nakagawa and Hiroshi Ogura
    Citation: Critical Care 2022 26:241
  6. While the Glasgow coma scale (GCS) is one of the strongest outcome predictors, the current classification of traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormo...

    Authors: Cecilia A. I. Åkerlund, Anders Holst, Nino Stocchetti, Ewout W. Steyerberg, David K. Menon, Ari Ercole and David W. Nelson
    Citation: Critical Care 2022 26:228
  7. Sepsis is a heterogeneous syndrome, and the identification of clinical subphenotypes is essential. Although organ dysfunction is a defining element of sepsis, subphenotypes of differential trajectory are not w...

    Authors: Zhenxing Xu, Chengsheng Mao, Chang Su, Hao Zhang, Ilias Siempos, Lisa K. Torres, Di Pan, Yuan Luo, Edward J. Schenck and Fei Wang
    Citation: Critical Care 2022 26:197
  8. Interleukin (IL)-18 is a marker of inflammasome activation, and high baseline plasma IL-18 is associated with increased mortality in patients with sepsis-induced ARDS. The aim of this analysis was to determine...

    Authors: Andrew James Boyle, Peter Ferris, Ian Bradbury, John Conlon, Manu Shankar-Hari, Angela J. Rogers, Cecilia M. O’Kane and Daniel F. McAuley
    Citation: Critical Care 2022 26:164
  9. Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that are often mi...

    Authors: Yidi Qin, Kate F. Kernan, Zhenjiang Fan, Hyun-Jung Park, Soyeon Kim, Scott W. Canna, John A. Kellum, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley…
    Citation: Critical Care 2022 26:128
  10. Late mortality risk in sepsis-survivors persists for years with high readmission rates and low quality of life. The present study seeks to link the clinical sepsis-survivors heterogeneity with distinct biologi...

    Authors: Sabri Soussi, Divya Sharma, Peter Jüni, Gerald Lebovic, Laurent Brochard, John C. Marshall, Patrick R. Lawler, Margaret Herridge, Niall Ferguson, Lorenzo Del Sorbo, Elodie Feliot, Alexandre Mebazaa, Erica Acton, Jason N. Kennedy, Wei Xu, Etienne Gayat…
    Citation: Critical Care 2022 26:114
  11. Trials comparing early and delayed strategies of renal replacement therapy in patients with severe acute kidney injury may have missed differences in survival as a result of mixing together patients at heterog...

    Authors: François Grolleau, Raphaël Porcher, Saber Barbar, David Hajage, Abderrahmane Bourredjem, Jean-Pierre Quenot, Didier Dreyfuss and Stéphane Gaudry
    Citation: Critical Care 2022 26:64
  12. The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems. In this study, we combine the ultrasound approach...

    Authors: Stefan Schmidt, Jana-Katharina Dieks, Michael Quintel and Onnen Moerer
    Citation: Critical Care 2021 25:405
  13. Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative a...

    Authors: Katherine D. Wick, Daniel F. McAuley, Joseph E. Levitt, Jeremy R. Beitler, Djillali Annane, Elisabeth D. Riviello, Carolyn S. Calfee and Michael A. Matthay
    Citation: Critical Care 2021 25:404
  14. Authors: Jean-Louis Vincent, Mervyn Singer, Sharon Einav, Rui Moreno, Julia Wendon, Jean-Louis Teboul, Jan Bakker, Glenn Hernandez, Djillali Annane, Angélique M. E. de Man, Xavier Monnet, V. Marco Ranieri, Olfa Hamzaoui, Jukka Takala, Nicole Juffermans, Jean-Daniel Chiche…
    Citation: Critical Care 2021 25:397
  15. Timely recognition of hemodynamic instability in critically ill patients enables increased vigilance and early treatment opportunities. We develop the Hemodynamic Stability Index (HSI), which highlights situat...

    Authors: Asif Rahman, Yale Chang, Junzi Dong, Bryan Conroy, Annamalai Natarajan, Takahiro Kinoshita, Francesco Vicario, Joseph Frassica and Minnan Xu-Wilson
    Citation: Critical Care 2021 25:388
  16. A high body mass index (BMI) has been associated with decreased mortality in critically ill patients. This association may, in part, relate to the impact of BMI on glycemia. We aimed to study the relationship ...

    Authors: Drago Plečko, Nicolas Bennett, Johan Mårtensson and Rinaldo Bellomo
    Citation: Critical Care 2021 25:378
  17. There is ongoing demographic ageing and increasing longevity of the population, with previously devastating and often-fatal diseases now transformed into chronic conditions. This is turning multi-morbidity int...

    Authors: Michael Beil, Hans Flaatten, Bertrand Guidet, Sigal Sviri, Christian Jung, Dylan de Lange, Susannah Leaver, Jesper Fjølner, Wojciech Szczeklik and Peter Vernon van Heerden
    Citation: Critical Care 2021 25:330
  18. A personalized mechanical ventilation approach for patients with adult respiratory distress syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging, and biological phenotypes may i...

    Authors: Paolo Pelosi, Lorenzo Ball, Carmen S. V. Barbas, Rinaldo Bellomo, Karen E. A. Burns, Sharon Einav, Luciano Gattinoni, John G. Laffey, John J. Marini, Sheila N. Myatra, Marcus J. Schultz, Jean Louis Teboul and Patricia R. M. Rocco
    Citation: Critical Care 2021 25:250
  19. Individualized positive end-expiratory pressure (PEEP) by electrical impedance tomography (EIT) has potential interest in the optimization of ventilation distribution in acute respiratory distress syndrome (AR...

    Authors: Huaiwu He, Yi Chi, Yingying Yang, Siyi Yuan, Yun Long, Pengyu Zhao, Inéz Frerichs, Feng Fu, Knut Möller and Zhanqi Zhao
    Citation: Critical Care 2021 25:230