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Dose intensified radiation therapy for the treatment of pancreatic cancer, implementation and prerequisites

New Content Item (4)Guest Edited by Dr Pirus Ghadjar.

Modern radiation therapy techniques such as Intensity-modulated radiation therapy (IMRT) / rotational techniques, stereotactic body radiation therapy and proton therapy, as well as the use of novel image guided approaches, allow the delivery of higher tumor doses with acceptable toxicity rates. Moreover, novel molecular markers and imaging approaches at baseline and during treatment, can guide radiation therapy and serve as prognostic markers, and potentially also as predictive markers. 

The aim of this thematic series is to collect the current knowledge and limitations of dose intensified radiation therapy for the treatment of pancreatic cancer and it´s pre-requisites in terms of modern radiation therapy techniques.

  1. Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine t...

    Authors: Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr and Kirsten Lauber
    Citation: Radiation Oncology 2019 14:141
  2. Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC th...

    Authors: William A. Hall and Karyn A. Goodman
    Citation: Radiation Oncology 2019 14:114
  3. Different studies have proved in recent years that hypofractionated radiotherapy (RT) improves overall survival of patients affected by locally advanced, unresectable, pancreatic cancer.

    Authors: Luca Boldrini, Davide Cusumano, Francesco Cellini, Luigi Azario, Gian Carlo Mattiucci and Vincenzo Valentini
    Citation: Radiation Oncology 2019 14:71
  4. Neoadjuvant radio(chemo)therapy of non-metastasized, borderline resectable or unresectable locally advanced pancreatic cancer is complex and prone to cause side-effects, e.g., in gastrointestinal organs. Inten...

    Authors: Sarah Stefanowicz, Kristin Stützer, Sebastian Zschaeck, Annika Jakobi and Esther G. C. Troost
    Citation: Radiation Oncology 2018 13:228