Organoids and Tissue/Organ Chips

Stem Cell Research & Therapy   is calling for submissions to our collection on Organoids and Tissue/Organ Chips. The field of, “Organoids and tissue/organ chips”, represents groundbreaking advances in therapeutics, diagnostics, regenerative medicine and biomedical research. Organoids and spheroids are three-dimensional structures that mimic the architecture and function of specific organs or tissues in a laboratory setting. They are derived from pluripotent stem cells, iPSCs or adult tissue stem cells and are capable of self-organization and differentiation into various cell types. They have revolutionized disease modeling and drug screening, allowing researchers to study human biology and pathology in a more accurate and personalized manner. Moreover, microfluidic tissue/organ chips recreate the complexity of human organs by incorporating multiple cell types, nutrient and growth factor supplies, and physiological cues, including mechanical, electrical and even magnetic signals. These chips offer a platform for studying 3D, organ-level function, disease mechanisms, and drug responses with greater precision than 2D cell culture systems. The integration of organoids and tissue/organ chips has led to the development of more realistic models for drug discovery, toxicity testing, diagnostics, therapeutics and personalized medicine, bridging the gap between in vitro experimentation and clinical applications. This thematic series aims to highlight the state of the art as these technologies continue to evolve, they hold tremendous potential for advancing our understanding of human biology and accelerating the development of novel therapies.

We invite authors to submit reviews/original articles describing the utility of pluripotent stem cells or adult tissue stem cells as functional units of Organoids and Tissue/Organ Chips.