Oncogenic Signaling of Tyrosine Kinase in Cancer: Challenges and Therapeutic Opportunities
Tyrosine Kinase Receptors
Challenges and Therapeutic Opportunities
Series Editor: Christophe Nicot
Molecular Cancer is excited to present a series of original research and review articles that serves as an intellectual road map in the field of molecular oncology. The role of receptor tyrosine kinases (RTKs) in cancer began only about three decades ago; however, the amount of research and progress dedicated to the study of RTKs has been explosive, considering the vast quantity of known RTKs and their unique mechanisms in manipulating cellular signaling pathways. These articles report on all aspects related to expression, regulation and function of receptor tyrosine kinases (RTKs), non-receptor tyrosine kinases and other kinases in oncogenic signaling in cancer cells. The series aims to highlight significant and quality new findings related to targeted therapies, tyrosine kinase inhibitors (TKI), genetic and epigenetic mechanisms of acquired resistance to TKI, clinical trials and pre-clinical studies.