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Osteoarthritis - from basic and translational approaches to clinical practice

Guest Editor: Professor Ali Mobasheri (University of Surrey, UK)

Osteoarthritis (OA) is the most common form of arthritis and is characterised by damage or breakdown of articular cartilage in load-bearing joints, particularly in the knees, hips and hands. The disorder is one of the leading causes of disability worldwide and results in pain, stiffness, joint deformity and loss of joint mobility, which often develop slowly over time. There are a number of risk factors associated with OA, including age, obesity, metabolic disease, previous joint injury, abnormal joint loading and biomechanics, genetics and systemic inflammation. However, OA predominantly affects older people, often co-existing with other comorbid conditions associated with aging.

Read the published content in this thematic series covering all aspects of research into osteoarthritis from studies investigating the underlying pathophysiological mechanisms through to those describing clinical practice.

  1. Content type: Research article

    Accelerated knee osteoarthritis (AKOA) is characterized by more pain, impaired physical function, and greater likelihood to receive a joint replacement compared to individuals who develop the typical gradual o...

    Authors: Matthew S. Harkey, Julie E. Davis, Bing Lu, Lori Lyn Price, Robert J. Ward, James W. MacKay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2019 20:241

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  2. Content type: Research article

    High molecular weight (HMW) hyaluronic acid (HA) is a treatment option for knee osteoarthritis (OA). The efficacy of HMW-HA in knee OA is investigated extensively, but the effectiveness in patients in the work...

    Authors: Job Hermans, Sita M. A. Bierma-Zeinstra, Pieter K. Bos, Dieu Donne Niesten, Jan A. N. Verhaar and Max Reijman

    Citation: BMC Musculoskeletal Disorders 2019 20:196

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  3. Content type: Research article

    Osteoarthritis (OA) in the thumb carpometacarpal joint (CMCJ) is a prevalent disease which may lead to structural damage, severe pain and functional limitations. Evidence-based treatment recommendations state ...

    Authors: Else Marit Holen Gravås, Anne Therese Tveter, Randi Nossum, Ruth Else Mehl Eide, Åse Klokkeide, Karin Hoegh Matre, Monika Olsen, Øyvor Andreassen, Nina Østerås, Ida Kristin Haugen and Ingvild Kjeken

    Citation: BMC Musculoskeletal Disorders 2019 20:180

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  4. Content type: Research article

    There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consid...

    Authors: Jonathon Charlesworth, Jane Fitzpatrick, Nirmala Kanthi Panagodage Perera and John Orchard

    Citation: BMC Musculoskeletal Disorders 2019 20:151

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  5. Content type: Research article

    It has been suggested that smoking is associated with reduced risk of knee osteoarthritis (OA). However, supplementary studies are needed to further investigate any such potential association. Thus, our aim wa...

    Authors: Marianne Bakke Johnsen, Kenneth Pihl, Nis Nissen, Rasmus Reinholdt Sørensen, Uffe Jørgensen, Martin Englund and Jonas Bloch Thorlund

    Citation: BMC Musculoskeletal Disorders 2019 20:141

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  6. Content type: Research article

    The synovial membrane adjacent to the articular cartilage is home to synovial mesenchymal progenitor cell (sMPC) populations that have the ability to undergo chondrogenesis. While it has been hypothesized that...

    Authors: Asmaa Affan, Nedaa Al-Jezani, Pamela Railton, James N. Powell and Roman J. Krawetz

    Citation: BMC Musculoskeletal Disorders 2019 20:125

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  7. Content type: Research article

    Comprehensive national joint replacement registries with well-validated data offer unique opportunities for examining the potential future burden of hip and knee osteoarthritis (OA) at a population level. This...

    Authors: Ilana N. Ackerman, Megan A. Bohensky, Ella Zomer, Mark Tacey, Alexandra Gorelik, Caroline A. Brand and Richard de Steiger

    Citation: BMC Musculoskeletal Disorders 2019 20:90

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  8. Content type: Research article

    There is a pressing need to enhance osteoarthritis (OA) research to find ways of alleviating its enormous individual and societal impact due to the high prevalence, associated disability, and extensive costs.

    Authors: David J. Hunter, Philippa J. A. Nicolson, Christopher B. Little, Sarah R. Robbins, Xia Wang and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2019 20:74

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  9. Content type: Research article

    Preclinical osteoarthritis models where damage occurs spontaneously may better reflect the initiation and development of human osteoarthritis. The aim was to assess the commercial pig as a model of spontaneous...

    Authors: Mhairi A. Macfadyen, Zoe Daniel, Sara Kelly, Tim Parr, John M. Brameld, Andrew J. Murton and Simon W. Jones

    Citation: BMC Musculoskeletal Disorders 2019 20:70

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  10. Content type: Research article

    Osteoarthritis is a degradative joint disease found in humans and commercial swine which can develop from a number of factors, including prior joint trauma. An impact injury model was developed to deliver in v...

    Authors: R. S. McCulloch, P. L. Mente, A. T. O’Nan and M. S. Ashwell

    Citation: BMC Musculoskeletal Disorders 2018 19:449

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  11. Content type: Research article

    Osteoarthritis (OA) is associated with worsening physical function and a high prevalence of comorbid health conditions. In particular, cardiovascular disease (CVD) risk is higher in individuals with OA than th...

    Authors: Michela Corsi, Carolina Alvarez, Leigh F. Callahan, Rebecca J. Cleveland, Yvonne M. Golightly, Joanne M. Jordan, Amanda E. Nelson, Jordan Renner, Allen Tsai and Kelli D. Allen

    Citation: BMC Musculoskeletal Disorders 2018 19:393

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  12. Content type: Research article

    In this paper we investigate patients seeking care for a new diagnosis of shoulder osteoarthritis (OA) and the association between a patient’s initial physician specialty choice and one-year surgical and conse...

    Authors: Sarah B Floyd, Cole G Chapman, Ellen Shanley, Lauren Ruffrage, Eldon Matthia, Peter Cooper and John M Brooks

    Citation: BMC Musculoskeletal Disorders 2018 19:349

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  13. Content type: Research article

    The Pain Coping Skills Training for African Americans with OsteoaRTthritis (STAART) trial is examining the effectiveness of a culturally enhanced pain coping skills training (CST) program for African Americans wi...

    Authors: Kelli D. Allen, Liubov Arbeeva, Crystal W. Cené, Cynthia J. Coffman, Kimberlea F. Grimm, Erin Haley, Francis J. Keefe, Caroline T. Nagle, Eugene Z. Oddone, Tamara J. Somers, Yashika Watkins and Lisa C. Campbell

    Citation: BMC Musculoskeletal Disorders 2018 19:337

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  14. Content type: Research article

    Knee bone shape differs between men and women and the incidence of knee osteoarthritis (OA) is higher in women than in men. Therefore, the purpose of the present study was to determine whether the observed dif...

    Authors: Barton L. Wise, Jingbo Niu, Yuqing Zhang, Felix Liu, Joyce Pang, John A. Lynch and Nancy E. Lane

    Citation: BMC Musculoskeletal Disorders 2018 19:331

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  15. Content type: Research article

    Individuals with advanced hip osteoarthritis (OA) exhibit generalized muscle weakness of the affected limb and so clinical practice guidelines recommend strength training for the management of hip OA. However,...

    Authors: Aderson Loureiro, Maria Constantinou, Laura E. Diamond, Belinda Beck and Rod Barrett

    Citation: BMC Musculoskeletal Disorders 2018 19:303

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  16. Content type: Research article

    This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29–59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoa...

    Authors: Joyce A. C. van Tunen, George Peat, Alessio Bricca, Lars B. Larsen, Jens Søndergaard, Trine Thilsing, Ewa M. Roos and Jonas B. Thorlund

    Citation: BMC Musculoskeletal Disorders 2018 19:300

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  17. Content type: Research article

    Osteoarthritis (OA) is a leading cause of pain and disability. NICE OA guidelines (2008) recommend that patients with OA should be offered core treatments in primary care. Assessments of OA management have ide...

    Authors: Emma Louise Healey, Ebenezer K. Afolabi, Martyn Lewis, John J. Edwards, Kelvin P. Jordan, Andrew Finney, Clare Jinks, Elaine M. Hay and Krysia S. Dziedzic

    Citation: BMC Musculoskeletal Disorders 2018 19:295

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  18. Content type: Research article

    The major complaint of knee osteoarthritis (OA) is persistent pain. Unlike acute inflammatory pain, persistent pain is usually difficult to manage since its pathology is not fully understood. To elucidate the ...

    Authors: Takashi Hoshino, Kunikazu Tsuji, Hiroaki Onuma, Mio Udo, Hiroko Ueki, Masako Akiyama, Kahaer Abula, Hiroki Katagiri, Kazumasa Miyatake, Toshihumi Watanabe, Ichiro Sekiya, Hideyuki Koga and Takeshi Muneta

    Citation: BMC Musculoskeletal Disorders 2018 19:291

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  19. Content type: Research article

    To investigate (1) the association of specific biomechanical factors with knee osteoarthritis and knee osteoarthritis development, and (2) the impact of other relevant risk factors on this association.

    Authors: Joyce A. C. van Tunen, Andrea Dell’Isola, Carsten Juhl, Joost Dekker, Martijn Steultjens, Jonas B. Thorlund and Hans Lund

    Citation: BMC Musculoskeletal Disorders 2018 19:273

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  20. Content type: Study protocol

    Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and struc...

    Authors: Kade L. Paterson, David J. Hunter, Ben R. Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P. Yu, Bing Hui Wang, David Connell, James Linklater and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2018 19:272

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  21. Content type: Research article

    The progressive, debilitating nature of knee and hip osteoarthritis can result in severe, persistent pain and disability, potentially leading to a need for total joint arthroplasty (TJA) in end-stage osteoarth...

    Authors: Kristine Godziuk, Carla M. Prado, Linda J. Woodhouse and Mary Forhan

    Citation: BMC Musculoskeletal Disorders 2018 19:271

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  22. Content type: Research article

    Sufficient lower extremity muscle strength is necessary for performing functional tasks, and individuals with knee osteoarthritis demonstrate thigh muscle weakness compared to controls. It has been suggested t...

    Authors: Brittney A. Luc-Harkey, Clare E. Safran-Norton, Lisa A. Mandl, Jeffrey N. Katz and Elena Losina

    Citation: BMC Musculoskeletal Disorders 2018 19:258

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  23. Content type: Research article

    To examine whether number of physical therapy (PT) visits or amount of use of an internet-based exercise training (IBET) program is associated with differential improvement in outcomes for participants with kn...

    Authors: Megan Pignato, Liubov Arbeeva, Todd A. Schwartz, Leigh F. Callahan, Jennifer Cooke, Yvonne M. Golightly, Adam P. Goode, Bryan C. Heiderscheit, Carla Hill, Kim M. Huffman, Herbert H. Severson and Kelli D. Allen

    Citation: BMC Musculoskeletal Disorders 2018 19:238

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  24. Content type: Study protocol

    Knee osteoarthritis (OA) is a leading cause of musculoskeletal pain and disability globally, and abnormal knee loading is central to disease pathogenesis. Clinical guidelines recommend clinicians provide advic...

    Authors: Kade L. Paterson, Kim L. Bennell, Tim V. Wrigley, Ben R. Metcalf, Penny K. Campbell, Jessica Kazsa and Rana S. Hinman

    Citation: BMC Musculoskeletal Disorders 2018 19:219

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  25. Content type: Study protocol

    Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity ...

    Authors: Zoe Paskins, Gemma Hughes, Helen Myers, Emily Hughes, Susie Hennings, Andrea Cherrington, Amy Evans, Melanie Holden, Kay Stevenson, Ajit Menon, Kieran Bromley, Philip Roberts, Alison Hall, George Peat, Clare Jinks, Raymond Oppong…

    Citation: BMC Musculoskeletal Disorders 2018 19:218

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  26. Content type: Study protocol

    Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate to treat knee osteoarthritis (OA) patients. In a pilot study, we demonstrated that zoledronic acid reduced knee pain and s...

    Authors: Dawn Aitken, Laura L. Laslett, Guoqi Cai, Catherine Hill, Lyn March, Anita E. Wluka, Yuanyuan Wang, Leigh Blizzard, Flavia Cicuttini and Graeme Jones

    Citation: BMC Musculoskeletal Disorders 2018 19:217

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  27. Content type: Research article

    There is consistent evidence from observational studies of an association between occupational lifting and carrying of heavy loads and the diagnosis of hip osteoarthritis. However, due to the heterogeneity of ...

    Authors: Andreas Seidler, Laura Lüben, Janice Hegewald, Ulrich Bolm-Audorff, Annekatrin Bergmann, Falk Liebers, Christina Ramdohr, Karla Romero Starke, Alice Freiberg and Susanne Unverzagt

    Citation: BMC Musculoskeletal Disorders 2018 19:182

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  28. Content type: Research article

    Cartilage calcification (CC) is associated with osteoarthritis (OA) in weight-bearing joints, such as the hip and the knee. However, little is known about the impact of CC and degeneration on other weight-bear...

    Authors: Jan Hubert, Lukas Weiser, Sandra Hischke, Annemarie Uhlig, Tim Rolvien, Tobias Schmidt, Sebastian Karl Butscheidt, Klaus Püschel, Wolfgang Lehmann, Frank Timo Beil and Thelonius Hawellek

    Citation: BMC Musculoskeletal Disorders 2018 19:169

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  29. Content type: Research article

    Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with d...

    Authors: Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda and Kenji Miyamoto

    Citation: BMC Musculoskeletal Disorders 2018 19:157

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  30. Content type: Research article

    The Knee Injury and Osteoarthritis Outcome Score (KOOS) is a commonly used knee assessment and outcome tool in both clinical work and research. However, it has not been formally translated and validated in Fin...

    Authors: Juhani Multanen, Mikko Honkanen, Arja Häkkinen and Ilkka Kiviranta

    Citation: BMC Musculoskeletal Disorders 2018 19:155

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  31. Content type: Study protocol

    Lower limb strengthening, especially the quadriceps training, is of much necessity for patients with knee osteoarthritis (KOA). Previous studies suggest that strengthening of the hip muscles, especially the hip a...

    Authors: Yujie Xie, Chi Zhang, Wei Jiang, Juan Huang, Lili Xu, Guoyin Pang, Haiyan Tang, Ruyan Chen, Jihua Yu, Shengmin Guo, Fangyuan Xu and Jianxiong Wang

    Citation: BMC Musculoskeletal Disorders 2018 19:147

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  32. Content type: Study protocol

    To increase the uptake of key clinical recommendations for non-surgical management of knee osteoarthritis (OA) and improve patient outcomes, we developed a new model of service delivery (PARTNER model) and an ...

    Authors: David J. Hunter, Rana S. Hinman, Jocelyn L. Bowden, Thorlene Egerton, Andrew M. Briggs, Stephen J. Bunker, Jessica Kasza, Andrew B. Forbes, Simon D. French, Marie Pirotta, Deborah J. Schofield, Nicholas A. Zwar and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2018 19:132

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2018 19:443

  33. Content type: Research article

    Differences between staged bilateral total knee replacement (TKR) and simultaneous bilateral TKR have been investigated, but few studies have investigated differences in the functional improvements resulting f...

    Authors: Yu-Hao Huang, Chin Lin, Jia-Hwa Yang, Leou-Chyr Lin, Chih-Yuan Mou, Kwo-Tsao Chiang, Man-Gang Lee, Hsien-Feng Chang, Hsueh-Lu Chang, Wen Su, Shih-Jen Yeh, Hung Chang, Chih-Chien Wang and Sui-Lung Su

    Citation: BMC Musculoskeletal Disorders 2018 19:87

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  34. Content type: Research article

    Articular cartilage degeneration has been evaluated by magnetic resonance imaging (MRI). However, this method has several problems, including its time-consuming nature and the requirement of a high magnetic fi...

    Authors: Okihiro Onishi, Kazuya Ikoma, Masamitsu Kido, Yukichi Kabuto, Keiichiro Ueshima, Ken-ichi Matsuda, Masaki Tanaka and Toshikazu Kubo

    Citation: BMC Musculoskeletal Disorders 2018 19:81

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  35. Content type: Research article

    Knee osteoarthritis (OA) is the most common form of arthritis affecting the elderly. Understanding the risk factors for knee OA has been derived from cross sectional studies. There have been few longitudinal s...

    Authors: Jong Jin Yoo, Dong Hyun Kim and Hyun Ah Kim

    Citation: BMC Musculoskeletal Disorders 2018 19:80

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  36. Content type: Research article

    Few studies have examined patterns of specific sleep problems among individuals with osteoarthritis (OA). The primary objective of this study was to examine prevalence of symptoms of insomnia and obstructive s...

    Authors: Shannon Stark Taylor, Jaime M. Hughes, Cynthia J. Coffman, Amy S. Jeffreys, Christi S. Ulmer, Eugene Z. Oddone, Hayden B. Bosworth, William S. Yancy Jr and Kelli D. Allen

    Citation: BMC Musculoskeletal Disorders 2018 19:79

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  37. Content type: Research article

    Mobilization of mesenchymal stem cells (MSCs) from the synovium was revealed using a “suspended synovium culture model” of osteoarthritis (OA). The pathology of rheumatoid arthritis (RA) differs from that of O...

    Authors: Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Hideyuki Koga, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa and Ichiro Sekiya

    Citation: BMC Musculoskeletal Disorders 2018 19:78

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  38. Content type: Research article

    Knee osteoarthritis patients may become physically inactive due to pain and functional limitations. Whether physical activity exerts a protective or harmful effect depends on the frequency, intensity, time and...

    Authors: Maik Sliepen, Elsa Mauricio, Matthijs Lipperts, Bernd Grimm and Dieter Rosenbaum

    Citation: BMC Musculoskeletal Disorders 2018 19:64

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  39. Content type: Research article

    Exercise interventions improve clinical outcomes of pain and function in adults with knee pain due to osteoarthritis and higher levels of physical activity are associated with lower severity of pain and higher...

    Authors: Jonathan G. Quicke, Nadine E. Foster, Peter R. Croft, Reuben O. Ogollah and Melanie A. Holden

    Citation: BMC Musculoskeletal Disorders 2018 19:59

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