Guest Editors:
Bharat Gurnani: Om Prakash Eye Institute, India
Ho sik Hwang: Catholic University of Korea, Seoul
Rohan Bir Singh: Schepens Eye Research Institute of Massachusetts, USA
This BMC Ophthalmology collection is focused on the debilitating chronic diseases of the ocular surface, with the aim to collate recent advances and to comprehensively review developments in Ocular Surface Disaese research.
Bharat Gurnani: Om Prakash Eye Institute, India
Dr. Bharat Gurnani is a Cataract, Cornea, External Diseases, Ocular Surface, Trauma and Refractive Surgery consultant at Om Prakash Eye Institute, Amritsar, Punjab, India and has keen interest in research and publication. He has published more than 200 peer reviewed articles in various international and national journals and has reviewed over 350 papers for various journals. His keen interests are microbial keratitis, keratoconus, dry eye, ocular trauma and lamellar surgeries.
Ho sik Hwang: Catholic University of Korea, SeoulDr. Ho sik Hwang, MD, PhD works as an associate professor of ophthalmology at Catholic university of Korea, Seoul. His research areas of interest include dry eye syndrome, Meibomian gland, conjunctival goblet cell and multifocal intraocular lens.
Rohan Bir Singh: Schepens Eye Research Institute of Massachusetts, USADr. Rohan Bir Singh is a Fellow at the Laboratory of Corneal Immunology, Transplantation and Regeneration at the Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School. He graduated from the Government Medical College & Hospital, Panjab University, India. His research interests include dry eye disease and corneal transplantation immunology, clinical manifestations of ocular graft-versus-host disease and epidemiology of corneal disorders in the United States. Dr. Singh is also a visiting lecturer at the Division of Ophthalmology and Vision Sciences, Adelaide Medical School, the University of Adelaide, Australia. He has published more than 50 peer reviewed publications and chapters and edited three textbooks. He is a member of the editorial board of BMC Ophthalmology, Therapeutic Advances in Ophthalmology and Frontiers in Ophthalmology and has peer reviewed articles for more than 20 journals.
Ocular surface diseases (OSD) such as dry eye disease or anterior blepharitis have become more prevalent, causing visual disturbances, ocular discomfort in patients; however, these disorders continue to remain undiagnosed in majority of the populace. The evidence suggests that there is an increasing incidence of ocular allergies requiring long-term management.
In the past two decades, there has been an increased research focus on the underlying pathophysiology, diagnosis and treatment of these diseases. Novel biomarkers found in the tear fluid and alterations in the ocular microbiome are increasingly gaining recognition as possible diagnostic tools and hence gaining interest of research groups globally.
We are launching a collection focused on the debilitating chronic diseases of the ocular surface, with the aim to collate recent advances and to comprehensively review developments in OSD research.
We are particularly interested in research on the pathogenesis of OSD as well as in studies describing novel patient-centric treatment strategies. We will be considering both basic and clinical research but strongly encourage authors to submit their experimental work to this collection. We are also interested in high-quality systematic reviews and meta-analyses from this field.
Potential topics include but are not limited to the following:
● Advances in treatment of dry eye disease, Meibomian gland dysfunction and blepharitis
● Basic research focused on the pathophysiology of OSD
● Newer imaging modalities for clinical diagnostics of OSD
● Ocular surface and tear biomarkers
● OSD as the consequence of ophthalmic surgery
● The ocular microbiome
● Ocular surface and aging
In recent years, insulin eye drops have attracted increasing attention from researchers and ophthalmologists. The aim of this study was to investigate the efficacy and possible mechanism of action of insulin e...
To elaborate the underlying mechanisms by which IL-1β promote progression of Dry eye disease(DED) through effect on pyroptosis and apoptosis of corneal epithelial cells(CECs).
In the present study, we aimed to evaluate the efficacy of the bandage contact lens (BCLs) in the treatment of dry eye disease (DED) after complicated cataract or/and intraocular lens (IOL) surgery.
Polyethylene covers have been proven to be effective in protecting the eyes in patients with decreased or disappeared blink reflexes, but their advantages compared to other conventional methods are still uncle...
To observe morphologic and functional changes in meibomian glands in pediatric patients with and without lower eyelid epiblepharon.
To evaluate the efficacy and safety of peribulbar triamcinolone acetonide injection for treating ocular myasthenia gravis (OMG), with a comparison of traditional oral drug therapy.
This study aims to assess how Romanian medical students suffer from dry eye disease symptoms, establish the prevalence and severity of dry eye (DE) symptoms and identify potential risk factors.
To investigate the validation of phenol red thread (PRT) test in a Chinese population by evaluating the intraobserver repeatability and interobserver reproducibility, determining correlations between the PRT t...
Inflammatory bowel disease (IBD) is associated with lacrimal gland dysfunction and ocular inflammation. The objective of this research was to elucidate the temporal relationships between IBD, dry eye disease (...
Peripheral ulcerative keratitis (PUK) is a group of inflammatory corneal ulcers with stromal thinning and peripheral localization. Amniotic membranes (AM) are used for their anti-inflammatory and healing prope...
A report of a Brittle cornea syndrome (BCS) case with bluish scleral discoloration, keratoglobus, and myopia based on multimodal imaging modalities including in vivo confocal microscopy (IVCM), high-definition...
We present six patients who developed Candida keratitis postoperatively. The clinical features, diagnostic testing including in vivo confocal microscopy, and outcomes are presented.
To investigate the role of neutrophils in corneal nerve regeneration.
The Keratoconus International Consortium (KIC) will allow better understanding of keratoconus.
Ocular surface squamous neoplasia (OSSN) comprises a wide spectrum of squamous tumors, from which corneal/conjunctival intraepithelial neoplasia (CIN) is the most common one. The classic treatment is complete ...
The aim of this work is to evaluate the safety and efficacy of repeated sessions of photo-activated chromophore for keratitis-cross linking (PACK-CXL) window absorption (WA) for the treatment of resistant bact...
Due to technological advancements, surgical invasiveness has been reduced. However, cataract surgery has been implicated in causing postoperative inflammation, including dry eye syndrome. The innate immune sys...
To observe the distribution characteristics of corneal higher-order aberrations (HOAs) in cataract patients, and analyze the relationship of HOAs with patients’ age and ocular biometric parameters.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and extremely serious drug-induced dermatological disorders. The ocular surface condition at the early stage has been little studied...
To investigate the distribution characteristics of conjunctival sac flora and assess the susceptibility of commonly used topical antimicrobial agents in normal children under the age of 18 in East China.
To compare the effect of traditional conjunctival sac swab sampling (A) with aerosolization ocular surface microorganism sampling (B),a novel microbial sampling method, in detecting ocular microbial infection.
Keratoconus is a degenerative disorder of the cornea leading to a protrusion and thinning with loss of visual acuity. The only treatment to halt the progression is corneal crosslinking (CXL), which uses ribofl...
To assess the prevalence of dry eye disease (DED) in the Uyghur population in Hotan, Xinjiang, and to identify risk factors associated with this disorder.
To evaluate changes in objective optical quality following intense pulsed light (IPL) treatment combined with meibomian gland (MG) expression (MGX) in patients with MG dysfunction (MGD).
The long-term use of visual display terminals (VDT) is linked to an increased risk of dry eye disease (DED). Numerous studies have indicated that ocular mucins play a vital role in the pathogenesis of DED. The...
To explore the changes in vasoactive intestinal peptide (VIP) concentration in tears post laser-assisted sub-epithelial keratomileusis (LASEK) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK) s...
Severe ocular surface disorders are one of the major blinding diseases, and a paucity of original tissue obscures successful reconstruction. We developed a new surgical technique of direct oral mucosal epithel...
Primary acquired nasolacrimal duct obstruction (PANDO) is frequently encountered in perimenopausal women, causing tear flow stagnation and resulting in a variety of ocular discomfort symptoms. However, little ...
This study aimed to explore the associations between Demodex infestation and the ocular surface characteristics of meibomian gland dysfunction (MGD) in different age groups, to further understand the effect of De...