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Organoids in Domestic Animals

3D culture models offer major opportunities to mimic living tissues and to model diseases. In recent years, great progress has been made in establishing 3D culture systems in humans and animals. 


In this collection we focus on veterinary applications of 3D culture models. This includes reviews on the progress and challenges in generating organoids in farm animal species, along with discussions on the development of skin, skeletal muscle, liver, intestinal, cerebral and mammary gland organoids in livestock.

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Edited by Dr Bertrand Pain


Call for Papers

Veterinary Research invites you to submit articles to Organoids in Domestic Animals. To submit your manuscript, please use our online submission system, and indicate in your cover letter that you would like the manuscript to be considered for this article collection.


For more information about the journal and how to submit your article to Veterinary Research, please see our submission guidelines. Any accepted articles will appear together on this collection page, as and when the publications are ready.



  1. Three-dimensional (3D) intestinal enteroids are powerful in vitro models for studying intestinal biology. However, due to their closed structure direct access to the apical surface is impeded, limiting high-th...

    Authors: Kate M. Sutton, Brigid Orr, Jayne Hope, Stina R. Jensen and Lonneke Vervelde
    Citation: Veterinary Research 2022 53:15
  2. The intestinal epithelium plays a variety of roles including providing an effective physical barrier and innate immune protection against infection. Two-dimensional models of the intestinal epithelium, 2D ente...

    Authors: Brigid Orr, Kate Sutton, Sonja Christian, Tessa Nash, Helle Niemann, Lone Lind Hansen, Mike J. McGrew, Stina Rikke Jensen and Lonneke Vervelde
    Citation: Veterinary Research 2021 52:142
  3. Small intestinal organoids, or enteroids, represent a valuable model to study host–pathogen interactions at the intestinal epithelial surface. Much research has been done on murine and human enteroids, however...

    Authors: Bjarne Vermeire, Liara M. Gonzalez, Robert J. J. Jansens, Eric Cox and Bert Devriendt
    Citation: Veterinary Research 2021 52:94

    The Correction to this article has been published in Veterinary Research 2021 52:107

  4. The number and severity of diseases affecting lung development and adult respiratory function have stimulated great interest in developing new in vitro models to study lung in different species. Recent breakth...

    Authors: Fabienne Archer, Alexandra Bobet-Erny and Maryline Gomes
    Citation: Veterinary Research 2021 52:77
  5. Typical two-dimensional (2D) culture models of skeletal muscle-derived cells cannot fully recapitulate the organization and function of living muscle tissues, restricting their usefulness in in-depth physiolog...

    Authors: Frederic Dessauge, Cindy Schleder, Marie-Hélène Perruchot and Karl Rouger
    Citation: Veterinary Research 2021 52:72
  6. Organoids are self-organizing, self-renewing three-dimensional cellular structures that resemble organs in structure and function. They can be derived from adult stem cells, embryonic stem cells, or induced pl...

    Authors: Soumya K. Kar, Jerry M. Wells, Esther D. Ellen, Marinus F. W. te Pas, Ole Madsen, Martien A. M. Groenen and Henri Woelders
    Citation: Veterinary Research 2021 52:43
  7. Within the past decades, major progress has been accomplished in isolating germ/stem/pluripotent cells, in refining culture medium and conditions and in establishing 3-dimensional culture systems, towards deve...

    Authors: Guillaume Bourdon, Véronique Cadoret, Gilles Charpigny, Anne Couturier-Tarrade, Rozenn Dalbies-Tran, Maria-José Flores, Pascal Froment, Mariam Raliou, Karine Reynaud, Marie Saint-Dizier and Alice Jouneau
    Citation: Veterinary Research 2021 52:42
  8. Organoids are three-dimensional structures that are derived from the self-organization of stem cells as they differentiate in vitro. The plasticity of stem cells is one of the major criteria for generating org...

    Authors: Bertrand Pain
    Citation: Veterinary Research 2021 52:38
  9. In livestock species, the monolayer of epithelial cells covering the digestive mucosa plays an essential role for nutrition and gut barrier function. However, research on farm animal intestinal epithelium has ...

    Authors: Martin Beaumont, Fany Blanc, Claire Cherbuy, Giorgia Egidy, Elisabetta Giuffra, Sonia Lacroix-Lamandé and Agnès Wiedemann
    Citation: Veterinary Research 2021 52:33
  10. The skin is a passive and active barrier which protects the body from the environment. Its health is essential for the accomplishment of this role. Since several decades, the skin has aroused a strong interest...

    Authors: Laurent Souci and Caroline Denesvre
    Citation: Veterinary Research 2021 52:21