Edited by Prof Alessandro Bartolomucci and Dr Fabio Virgili
Obesity and associated diseases (type-2 diabetes [T2D], hypertension, etc.) are rising exponentially to pandemic levels worldwide. Despite major advances in our understanding of the signaling pathways involved in energy homeostasis, we currently possess very few safe and effective therapeutic answers to obesity. Identifying new mechanisms that have the potential to inform about the development of more efficacious and safer drugs represents a major need for society and a challenge for the biomedical field. This latest thematic series in Genes and Nutrition features invited topic reviews by leaders in the field, which focus on established and novel major determinants of the Obesity epidemic such as dietary fat, branched chain amino acids and probiotics, and gene X environment interaction, as well as gut microbiota and microRNA.
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.
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Inflexibility of the plasma miRNA response following a high-carbohydrate meal in overweight insulin-resistant women
Metabolic inflexibility is a characteristic of insulin resistance, limiting the ability to transiently regulate oxidative metabolism and gene expression in response to nutrient availability. Little is known of...