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Edited by Prof Alessandro Bartolomucci and Dr Fabio Virgili

Obesity and associated diseases (type-2 diabetes [T2D], hypertension, etc.) are rising exponentially to pandemic levels worldwide. Despite major advances in our understanding of the signaling pathways involved in energy homeostasis, we currently possess very few safe and effective therapeutic answers to obesity. Identifying new mechanisms that have the potential to inform about the development of more efficacious and safer drugs represents a major need for society and a challenge for the biomedical field. This latest thematic series in Genes and Nutrition features invited topic reviews by leaders in the field, which focus on established and novel major determinants of the Obesity epidemic such as dietary fat, branched chain amino acids and probiotics, and gene X environment interaction, as well as gut microbiota and microRNA.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

View all collections published in Genes and Nutrition.

  1. Metabolic inflexibility is a characteristic of insulin resistance, limiting the ability to transiently regulate oxidative metabolism and gene expression in response to nutrient availability. Little is known of...

    Authors: F. Ramzan, R. F. D’Souza, B. R. Durainayagam, A. M. Milan, N. C. Roy, M. C. Kruger, C. J. Henry, C. J. Mitchell and D. Cameron-Smith
    Citation: Genes & Nutrition 2020 15:2
  2. Dietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and mai...

    Authors: Francesco Bifari, Chiara Ruocco, Ilaria Decimo, Guido Fumagalli, Alessandra Valerio and Enzo Nisoli
    Citation: Genes & Nutrition 2017 12:27
  3. Obesity, a major cause of death and disability, is increasing worldwide. Obesity is characterized by a chronic, low-grade inflammatory state which is suggested to play a critical role in the development of obe...

    Authors: Vibeke H. Telle-Hansen, Jacob J. Christensen, Stine M. Ulven and Kirsten B. Holven
    Citation: Genes & Nutrition 2017 12:26
  4. Obesity is a complex pathology associated with dysbiosis, metabolic alterations, and low-grade chronic inflammation promoted by immune cells, infiltrating and populating the adipose tissue. Probiotic supplemen...

    Authors: Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami and Giuditta Perozzi
    Citation: Genes & Nutrition 2017 12:25
  5. In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in mai...

    Authors: Giuseppe Iacomino and Alfonso Siani
    Citation: Genes & Nutrition 2017 12:23
  6. It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression ...

    Authors: Sabrina Duranti, Chiara Ferrario, Douwe van Sinderen, Marco Ventura and Francesca Turroni
    Citation: Genes & Nutrition 2017 12:18