Guest edited by John Lodge
Genes & Nutrition is proud to open this thematic series. Neuroprotection is a therapeutic approach to prevent, slow or halt the progression of neurodegenerative diseases (NDs) by inhibiting the pathogenic events that result in cell dysfunction and/or neuronal death. Although NDs show different clinical profiles, common molecular pathogenic mechanisms including oxidative stress, proteostasis, mitochondrial deficit, glutamate excitotoxicity, and neuroinflammation are observed in different NDs, suggesting converging pathways of neurodegeneration. This aspect can be potentially useful to develop common neuroprotective treatments with non-pharmacological interventions. In this regard, food components, such as nutraceuticals, and physical activity are emerging neuroprotection non-pharmacological approaches. Recent in vitro and in vivo studies indicate that nutraceuticals and physical activity have similar or complementary neuroprotection mechanisms suggesting new integrated approaches to enhance neuroprotective effects.
This thematic series collects topic reviews and researches by leaders in the field, which focus on the ability of nutraceuticals and physical activity to modulate recognized and novel cellular and molecular targets for preventing neurodegeneration.
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.
Please find out more about our journal and its policies, here. Submission guidelines can be found here, and please submit to the series via our submission system (there will be a field for which you can indicate if you are submitting to this series).
